Health Conditions Linked to Vitamin D Deficiency

Health Conditions Linked to Vitamin D Deficiency
24 Jan 2024
9 mins
Table Of Content
Health Conditions Linked to Vitamin D Deficiency

    Vitamin D is an essential nutrient vital for our overall health. It belongs to the steroid hormonal family since its first, classic function (like a hormone) is to regulate calcium and phosphorus in our body, and its second, non-classical function is cell proliferation and differentiation (cell growth), apoptosis, immune regulation, genome stability, and neurogenesis. Recently, many studies have revealed that Vitamin D is closely correlated with heart diseases, cancer, diabetes, autoimmune diseases, osteoporosis, infectious diseases, and many others. Hence, many experts strongly believe that vitamin D should be treated as a hormone rather than one among the traditional vitamins. Keep reading to know how vitamin D is related to other chronic diseases. 


    How is vitamin D synthesized?


    Vitamin D is a fat-soluble vitamin that can be obtained as a dietary supplement or found naturally in food. Additionally, it is made internally when sunlight's ultraviolet (UV) rays strike your skin and start the synthesis of vitamin D; that is why vitamin D is often called "the sunshine vitamin." Here's how it is produced in a simple equation:


    Sunlight (UVB rays) → Skin (creates Vitamin D3) → Liver (converts to 25(OH)D) → Kidneys (activate it) → Body (uses it for bone health and immune system)

    Relationship Unrevealed B/W Vitamin D and other chronic diseases


    Vitamin D and Osteoporosis


    As we all know, vitamin D is vital for bone health, playing a key role in calcium absorption. Hence, its deficiency can lead to weaker bones, increasing the risk of fractures, and causing bone softening. This results in osteoporosis. Hence, supplementing with Vitamin D is crucial in strengthening bones, reducing turnover, and, alongside calcium, lowering the risk of fractures.Taking vitamin D supplements can be an effective way to help prevent osteoporosis. However, balance is crucial as very high doses can be harmful. 

    Vitamin D and Cancer

    Did you know Vitamin D is a secret agent in our fight against cancer? Having enough Vitamin D is super important for keeping us healthy and might even help prevent deadly cancers.


    Here is how it works: Vitamin D travels around our body with the help of a special protein called Vitamin D binding protein (VDBP). Vitamin D can't do its job properly if we don't have enough of this protein. This is a big deal because studies have shown that when our levels of VDBP are low, we are more at risk for cancers like breast, prostate, and colorectal cancer.


    Now, here's a really interesting fact: people with Vitamin D levels below 20 ng/ml are at a 30 to 50% greater risk of developing colon, prostate, and breast cancer. But there is good news, too! One study found that postmenopausal women who upped their Vitamin D intake to 1100 IU daily significantly reduced their cancer risk by 60 to 77%! And it's not just those cancers; even liver cancer seems to be linked to low Vitamin D levels.

    Vitamin D and Heart Disease

    Did you know that Vitamin D is super important for heart health? Studies have freported that low Vitamin D levels are closely linked to heart-related issues. This includes things like high blood pressure and even the likelihood of developing hypertension. Vitamin D helps keep our cardiovascular system in good shape by reducing inflammation, preventing blood clots, and keeping our blood vessels flexible and healthy. It's like a little health guardian for our heart, ensuring everything runs smoothly. So, remember, getting enough Vitamin D is not just good for your bones; it's also crucial for a healthy heart!


    Vitamin D and Diabetes


    Vitamin D plays a big role in managing diabetes, especially Type 2 diabetes (T2DM). Low Vitamin D levels can lead to increased risks of T2DM because it's key in helping our body's cells respond well to insulin, which controls blood sugar. Vitamin D also reduces inflammation in the pancreas and affects how certain cells work, impacting blood sugar regulation. Plus, it influences the renin-angiotensin system, which is important for insulin secretion. Not enough Vitamin D can mean higher insulin resistance and blood sugar issues. But, the good news is that increasing Vitamin D can improve blood sugar control and reduce diabetes risks. So, getting enough vitamin D is not just good for our bones but also crucial for keeping our blood sugar in check! 

    Vitamin D and Obesity


    People who are obese often have low levels of Vitamin D, possibly because the extra body fat dilutes it. While it's unclear if low Vitamin D contributes to obesity, it's known that Vitamin D receptors are found in fat tissue, suggesting a potential link. Although low Vitamin D in obese individuals doesn't seem to harm their bones, it might affect other organs. The best approach for now is a healthy lifestyle with diet and exercise, which can improve both obesity and Vitamin D levels. Vitamin D supplements might be helpful for those who still have a deficiency after weight loss. 

    Vitamin D and Immune System Diseases

    Vitamin D plays a major role in keeping our immune system in check. It works like a regulator, ensuring our immune responses don't go overboard. This is important in preventing autoimmune diseases, where our body mistakenly attacks itself. Vitamin D, especially in its active form 1,25(OH)2D3, teams up with the Vitamin D receptor to work magic on immune cells like monocytes, macrophages, and T and B cells. For example, it calms certain T cells, reducing inflammation and slowing down chronic autoimmune diseases. It also boosts macrophages, our body's infection-fighting superheroes, and even makes sure our immune system doesn't get too trigger-happy by regulating certain immune triggers.

    Vitamin D and Neuropsychiatric Disorders


    Vitamin D is a brain booster. It's involved in making neurotransmitters, like the brain's communication wires, and helps balance calcium in the brain, which is super important for brain function. Plus, it's got antioxidant powers, protecting our brain cells. Studies suggest that getting enough of Vitamin D can lower the risk of depression and might even be linked to a lower risk of Alzheimer's disease, epilepsy, and other cognitive declines. It could do this by increasing certain protective proteins in the brain, boosting serotonin (the feel-good hormone), and even helping clear out harmful stuff in Alzheimer's patients.


    The Bottom Line

    In conclusion, the lack of enough Vitamin D, or 25OHD deficiency, plays a big role in various chronic diseases that are becoming more common as our population ages. We are seeing more cases of osteoporosis, heart disease, cancer, diabetes, and other long-term health problems. The tricky part is that many chronic conditions don't have specific treatments, or the treatments available only partially cure the disease. This is why focusing on prevention is key. The bottom line is that we need to keep digging into the world of Vitamin D and be aware of the signs of vitamin D. Understanding its role could be a game-changer in tackling these growing health challenges. 


    "D in the Day Keeps Fractures Away – Trust in Vitamin D!"

    Written by
    Dr VijayalakshmiMedical Content Writer
    AboutDr. Vijayalakshmi is a Medical Content Writer at MrMed. She completed her Bachelor of Dentistry (BDS) from Sri Ramakrishna Dental College, Coimbatore, in 2022, where she expertise in dental and clinical research. During her internship, she has also worked on various research projects and presented scientific papers in national UG seminars. Post her UG, she has upskilled in pharmacovigilance regulations and clinical trial methodology through certification courses. She is proficient in researching, writing, editing, and proofreading medical content and blogs.
    Tags :Vitamin D deficiency vitamin D and chronic diseasesOsteomalacia vitamin D and cancerosteoporosis