What to Eat for Improved Liver Health
30 Sep 2024
8 mins
What Foods Should I Eat To Support My Liver Health?Your liver is one of the most hardworking organs in your body. It is responsible for detoxifying your system, producing bile for digestion, and regulating nutrients. It's easy to take your liver for granted until problems arise, but why wait for issues when you can start nurturing it today? What you eat or drink plays a crucial role in whether you're aiming to detoxify or maintain your liver health.   How do you naturally improve liver health, especially with foods available in India? This article covers superfoods for liver health and detoxification, spices, herbs, and traditional Indian remedies for liver health that not only support liver function but also protect it from potential damage. Let's get to know some of the best foods for liver health in India [https://timesofindia.indiatimes.com/life-style/food-news/foods-that-can-naturally-reverse-liver-damage/articleshow/108923856.cms].   HOW DOES YOUR DIET AFFECT YOUR LIVER HEALTH?   Your liver is responsible for filtering everything you eat or drink, so your diet directly impacts its efficiency. Eating the right foods can help cleanse the liver and prevent it from becoming overwhelmed by toxins and unhealthy fats. On the flip side, consuming a poor diet loaded with processed foods, unhealthy fats, and excess sugars puts stress on the liver, potentially leading to conditions like fatty liver disease.   Luckily, an Indian diet is naturally rich in natural foods to cleanse your liver, and adopting certain traditional foods can go a long way in supporting liver health [https://www.mrmed.in/health-library/liver-care/liver-disease-awareness].   TOP 10 FOODS TO BOOST LIVER HEALTH   1. TURMERIC   Turmeric is a golden wonder of Indian kitchens, well known for its anti-inflammatory and antioxidant properties [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8227619/]. Curcumin, the active compound in turmeric, is known to boost liver health by increasing bile production and reducing liver inflammation.   Turmeric is especially beneficial for people suffering from liver issues like fatty liver disease. Simply add a pinch of turmeric to your meals, curries, or even your morning tea to experience its liver-protective benefits.   2. AMLA (INDIAN GOOSEBERRY)   Amla is a traditional Indian superfood and a rich source of vitamin C, which helps detoxify the liver and boosts immunity. Its antioxidants protect the liver from oxidative damage and help regenerate liver tissue.    Amla also stimulates digestive enzymes, which reduce the liver’s workload. You can eat it raw, as juice, or in the form of chutneys and pickles to support liver health and function. Its detoxifying and rejuvenating properties make it an essential part of a liver-friendly diet.   3. GARLIC   Garlic is known for its liver-boosting benefits due to its high levels of allicin and selenium, which help activate liver enzymes that flush out toxins. It also contains sulfur compounds that support liver detoxification and reduce oxidative stress.    Garlic is easy to incorporate into daily meals, whether raw, roasted, or cooked, making it a simple yet effective food for liver health. Regular use of garlic helps maintain a healthy liver and supports the detox process naturally.   4. LEAFY GREENS (SPINACH, METHI)   Leafy greens such as spinach and fenugreek (methi) are packed with chlorophyll, which plays a key role in liver detoxification and cleansing by absorbing toxins from the blood. They also increase bile production, which helps in fat digestion and detoxification.   Including leafy greens in your diet, whether as salads, soups, or curries, supports liver function and reduces its burden, promoting overall liver health. These greens are an excellent natural way to maintain liver vitality.   5. CUMIN AND CORIANDER SEEDS   Cumin and coriander seeds, widely used in Indian cooking, offer great benefits for liver health. Cumin stimulates bile production, aiding in the digestion of fats, while coriander seeds have detoxifying properties that cleanse the liver.    Soaking coriander seeds overnight and consuming the infused water on an empty stomach can help in natural liver detoxification. Both these spices are easy to include in your daily diet to support optimal liver function and digestion.   6. GINGER   Ginger is a powerhouse of anti-inflammatory properties, widely used in Indian cuisine. It contains gingerol, a bioactive compound that helps reduce oxidative stress and inflammation in the liver. Ginger also aids digestion, which lightens the liver’s load by helping the body break down fats more efficiently.    Additionally, its ability to stimulate bile production makes it beneficial for overall liver function. You can effortlessly add ginger to your dishes through ginger tea, curries, and soups or by adding fresh ginger to smoothies. Its detoxifying effects make it a fantastic addition to a liver-friendly diet.   7. BEETROOT   Beetroot is a natural liver cleanser, rich in antioxidants, fibre, and betalains, a group of phytonutrients that support detoxification. One of its standout components, betaine, helps the liver break down toxins and fats, making the detox process more efficient. Beetroot also increases the production of bile, which alleviates digestive challenges and lessens the burden on the liver.    Consuming beetroot regularly, whether in salads, juices, or roasted dishes, can significantly improve liver health and function. In addition to its detoxifying properties, beetroot helps shield the liver from oxidative harm resulting from free radicals.   8. BITTER GOURD (KARELA)   Remember how Anjali constantly offers Taarak, her famous karela juice, in Taarak Mehta Ka Ooltah Chashmah? While Taarak may run away from it, she’s actually onto something! Bitter gourd is a fantastic detoxifier for the liver, helping to purify the blood and reduce fat buildup, especially for those with fatty liver disease. Its bitter compounds support healthy bile production, aiding digestion and liver cleansing. Whether in curries or juice (like Anjali’s!), karela is a great natural way to keep your liver in top shape.   9. PAPAYA   Papaya is a liver-friendly fruit, rich in fibre and essential nutrients that support digestion and ease the liver's workload. The enzyme papain in papaya aids in protein digestion and supports liver detoxification. Additionally, it is rich in antioxidants, particularly vitamin C, which contributes to lowering inflammation and oxidative stress in the liver. This combination makes papaya beneficial for maintaining liver health and function.   Eating papaya regularly can enhance liver function by helping in the removal of toxins and other waste products. You can enjoy papaya fresh, in smoothies, or as a salad ingredient to promote healthy liver function. Its fibre content also helps in preventing constipation, further easing the liver's responsibilities.   10. LEMONS   Lemons are a highly effective and simple way to support liver health due to their high vitamin C content and natural detoxifying properties. Lemons help activate liver enzymes that aid in breaking down toxins and improving digestion. The citric acid in lemons helps the liver produce bile, which is essential for the digestive process.   Drinking warm lemon water in the morning is a well-known remedy to kickstart the detoxification process and improve overall liver function. Lemon juice can also be used as a tangy addition to salads, teas, and dishes to enjoy its liver-protective benefits. The antioxidants in lemons further help protect the liver from damage caused by free radicals.   WHAT TRADITIONAL INDIAN REMEDIES SUPPORT LIVER HEALTH?   According to Dr. Archana Sukumaran, a prominent Ayurveda expert, the liver, known as "Yakrit" in Sanskrit, acts as the abode of the Pitta entity and regulates digestive fire or Agni. To enhance liver effectiveness, it’s essential to detoxify it regularly. Here are some traditional remedies that can support liver health:   1. TRIPHALA   A blend of Amla (Indian Gooseberry), Haritaki, and Bibhitaki, Triphala is celebrated for its ability to promote liver detoxification. Dr. Archana mentions it as not only effective for constipation but also beneficial for the proper functioning of the liver. You can take it in tablet or powder form.   2. BHUMYAMALAKI (BHUMI AMLA)   Known as a powerful remedy for liver disorders, Bhumyamalaki is highly valued in Ayurvedic practices. It is used in cases of hepatomegaly and severe cirrhosis. Regular consumption under expert guidance can effectively guard the liver against future ailments.   3. ASHWAGANDHA   This potent herb, often called as Indian ginseng, helps restore liver balance by reducing stress and oxidative damage. It aids in enhancing bile production, which is crucial for digestive health. Ashwagandha can be taken in powdered form or in forms like Ashwagandhadi Lehyam.   4. LIQUORICE (MULETHI)   With its robust anti-inflammatory properties, Liquorice serves as a powerful liver tonic. It helps improve liver function and protects against toxins. It can alleviate symptoms associated with liver problems [https://www.mrmed.in/health-library/liver-care/recognize-liver-problems] like hepatitis [https://www.mrmed.in/health-library/liver-care/hepatitis-symptoms-types] and cirrhosis.   5. MILK THISTLE   Renowned for its active component, silymarin, this herb is a well-known protector of liver cells against damage from free radicals. Milk Thistle promotes the regeneration of liver tissue, making it effective for those affected by alcohol-related liver issues or viral hepatitis.   FREQUENTLY ASKED QUESTIONS (FAQS)   1. WHAT ARE THE SIGNS OF LIVER DAMAGE?    Common signs of liver damage [https://www.mrmed.in/health-library/liver-care/liver-damage-symptoms] include jaundice (yellowing of the skin and eyes), abdominal pain, fatigue, and swelling in the legs or abdomen. Changes in urine colour and stool can also indicate liver issues.   2. HOW DOES ALCOHOL AFFECT LIVER HEALTH?   Excessive alcohol consumption can lead to liver inflammation, fatty liver disease, alcoholic hepatitis, and cirrhosis. Moderation is key to preventing these conditions.   3. HOW CAN I MAKE MY LIVER STRONG?   You can strengthen your liver by maintaining a balanced diet rich in fruits, vegetables, whole grains, and healthy fats. Regular exercise, staying hydrated, limiting alcohol intake, and avoiding processed foods can also promote liver health.   4. ARE THERE SPECIFIC VITAMINS THAT SUPPORT LIVER HEALTH?   Yes, vitamins like B-complex, vitamin C, and vitamin E can support liver health. These vitamins help reduce inflammation and protect liver cells from damage.   FINAL THOUGHTS   Your liver works hard every day, so it’s essential to give it the support it needs. Adopting an Indian diet that focuses on natural foods like turmeric, garlic, amla, and leafy greens while minimising processed foods can go a long way in maintaining optimal liver health. Indian herbal remedies like Kutki and Milk Thistle can offer additional liver protection.   Incorporating omega-3-rich foods [https://www.webmd.com/diet/foods-high-in-omega-3] like flaxseeds and walnuts, along with traditional Indian spices, can help keep your liver functioning at its best. Simple changes in your meals can have a significant impact on your liver’s health, making it easier for your body to detoxify and thrive.   REFERENCES   1. https://www.afdil.com/blog/the-ayurvedic-approach-to-a-healthy-liver/ [https://www.afdil.com/blog/the-ayurvedic-approach-to-a-healthy-liver/] 2. https://www.hindustantimes.com/lifestyle/health/ayurveda-expert-suggests-herbs-and-spices-to-improve-liver-health-101654331414525.html [https://www.hindustantimes.com/lifestyle/health/ayurveda-expert-suggests-herbs-and-spices-to-improve-liver-health-101654331414525.html] 3. https://www.goodrx.com/well-being/diet-nutrition/foods-good-for-liver [https://www.goodrx.com/well-being/diet-nutrition/foods-good-for-liver] 4. https://ayurveda.umaoils.com/ayurvedic-solutions-for-womens-wellness-concerns/ [https://ayurveda.umaoils.com/ayurvedic-solutions-for-womens-wellness-concerns/]
Sakshi Anil More
12 Drug Side-Effects For Liver Medicines
30 Jul 2024
9 mins
Is Your Medication Hurting Your Liver? 12 Drugs to Be Aware OfDisclaimer: The information presented in this article is collected from various sources for educational purposes. Please consult with your doctor for personalised medical advice.   When it comes to medications, we often focus on their benefits, but it's equally important to be aware of potential risks. One such risk is liver damage, a serious concern that can arise from certain medications. The liver is an essential organ with a critical function in the detoxification of the body, and any harm to it can lead to significant health issues. In this article, we'll explore twelve medications that can potentially harm your liver, signs of liver damage, and tips for maintaining liver safety.   HOW DOES MEDICATION CAUSE LIVER DAMAGE?   The liver is responsible for breaking down most medications we use. During this process, some drugs can produce toxic byproducts that may harm liver cells. Additionally, certain medications can directly damage liver tissue, causing inflammation and other issues. This damage can disrupt the liver’s ability to function properly, potentially leading to serious health problems if not monitored and managed effectively.   WHAT ARE THE SIGNS OF LIVER DAMAGE?   Recognising the signs of liver damage [https://www.mrmed.in/health-library/liver-care/recognize-liver-problems] early can prevent severe health complications. Common symptoms include:   * Jaundice (yellowing of the skin and eyes) * Dark urine * Pale stool * Fatigue * Abdominal pain * Nausea and vomiting * Loss of appetite * Itching If you experience any of these symptoms while taking medication, consult your healthcare provider immediately.   WHICH MEDICATIONS ARE HARMFUL TO THE LIVER?   1. Acetaminophen: Widely used for pain relief and fever reduction, acetaminophen is safe when used as directed. However, high doses or prolonged use can cause severe liver damage.   2. Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Medications like ibuprofen and naproxen can cause liver inflammation and damage, especially with long-term use or in high doses.   3. Statins: Commonly prescribed for lowering cholesterol [https://www.mrmed.in/health-library/heart-care/reduce-cholesterol-with-food], statins like atorvastatin and simvastatin can occasionally lead to liver damage. Regular liver function tests are often recommended.   4. Antibiotics: Certain antibiotics, including amoxicillin-clavulanate, can cause liver damage. Symptoms may appear weeks after starting the medication.   5. Antifungal Medications: Antifungal medications [https://www.mrmed.in/condition/antifungal] like ketoconazole [https://www.mrmed.in/molecule/ketoconazole] and fluconazole can potentially harm the liver, especially when it is used over an extended period.   6. Antituberculosis Medications: Medications used to treat tuberculosis [https://www.mrmed.in/health-library/respiratory-disorder/world-tuberculosis-day], such as isoniazid and rifampin, are known to be hepatotoxic. Monitoring liver function during treatment is crucial.   7. Methotrexate: Used for treating cancer and autoimmune diseases, methotrexate [https://www.mrmed.in/molecule/methotrexate] can cause liver fibrosis and cirrhosis with long-term use.   8. Amiodarone: Used to treat irregular heartbeats, amiodarone [https://www.mrmed.in/molecule/amiodarone] can cause liver damage, especially with long-term use.   9. Valproic Acid: Commonly used to treat epilepsy [https://www.mrmed.in/health-library/neurology/international-epilepsy-day] and bipolar disorder, valproic acid carries a risk of liver damage, particularly in young children and patients with pre-existing liver conditions.   10. Azathioprine: Used to prevent organ rejection after transplantation and to treat autoimmune diseases [https://www.mrmed.in/health-library/immune-disorders/most-common-types-of-autoimmune-diseases], azathioprine [https://www.mrmed.in/molecule/azathioprine] can cause liver toxicity.   11. Anabolic Steroids: Often used for muscle building, anabolic steroids can cause severe liver damage, including liver cancer [https://cancerlibrary.mrmed.in/cancer-types/liver-cancer].   12. Herbal Supplements: Some herbal supplements, like kava and green tea extract, may pose a risk of liver toxicity, especially when taken in large amounts or for extended periods.   HOW CAN YOU PROTECT YOUR LIVER WHILE TAKING MEDICATION?   To safeguard your liver while on medication, it's crucial to adopt several proactive strategies. Here are some tips that you can follow:   1. Follow Prescriptions Carefully: Always take medications exactly as prescribed by your doctor. Do not increase the dose or frequency without consulting your doctor.   2. Regular Liver Function Tests: If you are on long-term medication, regular liver function tests can identify any potential issues or early signs of liver damage.   3. Avoid Alcohol: Combining alcohol with certain medications can increase the risk of liver damage. It’s best to avoid alcohol while taking hepatotoxic drugs.   4. Inform Your Doctor: Always inform your doctor about all the medications and supplements you are taking, including over-the-counter drugs and herbal products.   5. Be Aware of Drug Interactions: Some medicines can interact with each other, elevating the risk of liver damage. Make sure your healthcare provider is aware of all the drugs you are taking.   6. Monitor Symptoms: Look for any signs of liver damage and report them to your doctor immediately.   CAN LIVER DAMAGE BE REVERSED?   Identifying liver damage early is crucial for reversing its effects. When detected promptly, stopping the medication responsible often allows the liver to heal due to its ability to regenerate. This means that discontinuing the harmful drug can significantly improve liver function and prevent further harm. However, suppose the damage is severe or has progressed to conditions like cirrhosis or liver failure. In that case, recovery becomes more complex and may require long-term management or intensive treatments, such as a liver transplant.   In some situations, additional medications or lifestyle modifications may be necessary to support liver health. Your doctor might suggest a liver-friendly diet [https://www.mrmed.in/health-library/liver-care/liver-disease], abstaining from alcohol, and using medications to reduce inflammation or manage liver disease symptoms. Regular monitoring and follow-up tests are essential to track the liver's recovery and adjust treatment plans as needed.   ARE THERE ANY SAFE ALTERNATIVES TO THESE MEDICATIONS?   There may be safer alternatives to liver-toxic medications, depending on your condition and treatment needs. Here are some steps to consider:   1. Consult Your Healthcare Provider: Discuss potential alternatives with your doctor. They can assist you in assessing the risks and benefits of different medications and finding the best option for your health.   2. Consider Non-Pharmacological Treatments: For some conditions, non-drug treatments such as physical therapy, dietary changes, or lifestyle modifications [https://www.mrmed.in/health-library/liver-care/world-liver-day-2023] can be effective alternatives.   3. Explore Different Drug Classes: Your doctor might suggest medications from other drug classes that are less likely to cause liver damage. For example, certain pain relievers or anti-inflammatory drugs may be safer for individuals with a history of liver issues.   4. Use the Lowest Effective Dose: When using potentially liver-damaging medications, taking the lowest effective dose for the shortest necessary duration can help minimise risks.   HOW CAN LIFESTYLE CHOICES IMPACT LIVER HEALTH?   Your lifestyle choices play a big role in keeping your liver healthy. Here are some easy tips to follow:   1. Eat a Balanced Diet: Eat lots of fruits, veggies, and whole grains. Eating healthy [https://www.mrmed.in/health-library/health-care/benefits-of-eating-healthy] foods helps your liver stay in top shape.   2. Stay Active: Regular exercise, like walking or jogging, helps maintain a healthy weight. This is important because excess weight increases the risk of liver issues.   3. Avoid Toxins: Try to reduce your exposure to harmful chemicals and pollutants. These substances can put extra stress on your liver as it works to clear them from your body.   4. Stay Hydrated: Staying hydrated helps your liver work properly and flush out toxins. Aim to drink water throughout the day to support overall liver health.   5. Limit Alcohol: Too much alcohol can cause liver damage and lead to serious conditions like fatty liver or cirrhosis. It’s important to drink in moderation to protect your liver.   WHAT ARE SOME COMMON MYTHS ABOUT LIVER HEALTH?   1. "Only alcoholics get liver disease." While excessive alcohol consumption is a major cause of liver disease [https://www.mrmed.in/health-library/liver-care/liver-disease-awareness], other factors, such as medications and non-alcoholic fatty liver disease, can also cause liver problems.   2. “Liver cleanses can detox your liver." There is no scientific evidence that liver cleanses, or detoxes can improve liver health. The liver is naturally capable of detoxifying itself.   3. "You can’t live without your liver." While the liver is vital, partial liver transplants and liver regeneration are possible. However, severe liver damage can be life-threatening.   4. “Over-the-counter (OTC) Drugs Are Always Safe for the Liver” OTC medications like acetaminophen can cause significant liver damage if taken in large doses or improperly. Follow dosage instructions carefully and avoid mixing OTC drugs with alcohol.   5. “Liver Damage from Medication Is Always Immediate" Liver damage from medication often develops gradually, not immediately. Symptoms may appear weeks or even months after starting a medication. Regular monitoring is crucial, especially with long-term or high-risk medications.   PARTING WORDS   Maintaining your liver's health is essential for your overall well-being, and knowing how medications can affect it is vital. By recognising the signs of liver damage, sticking to your medication regimen, and adopting a healthy lifestyle, you can safeguard this essential organ. Remember, your liver's health is more than just avoiding alcohol or eating right; it's about being proactive with your medications. Stay informed, take action, and prioritise your liver’s safety to keep it functioning at its best.   REFERENCES   1. https://www.webmd.com/hepatitis/toxic-liver-disease [https://www.webmd.com/hepatitis/toxic-liver-disease] 2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127024/ [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127024/] 3. https://www.hopkinsmedicine.org/health/conditions-and-diseases/hepatitis/druginduced-hepatitis [https://www.hopkinsmedicine.org/health/conditions-and-diseases/hepatitis/druginduced-hepatitis] 4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160634/ [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160634/] 5. https://www.ncbi.nlm.nih.gov/books/NBK526106/ [https://www.ncbi.nlm.nih.gov/books/NBK526106/]
Sakshi Anil More
World Liver Day
19 Apr 2024
10 mins
Mindful Choices For Liver Health On World Liver DayIn these busy life schedules, we often forget to take care of one crucial role player, which removes unwanted toxins and impurities from our bodies. Yes, you guessed it right. It's our liver, known as the ultrafilter of the body. For this reason, today is designated and celebrated to create and spread awareness about the importance of the liver and its protection. Continue to read for more information!   HOW ARE LIVER DISEASES DIAGNOSED?   Your doctor diagnoses the type of liver disease by thoroughly conducting a physical examination and taking the history of your signs and symptoms. Your hepatologist may suggest liver function tests to assess the liver enzyme levels, a hepatitis profile to check for hepatitis infection and international normalized ratio (INR) /prothrombin time or PT to analyze your blood clotting ability. The blood reports may indicate the severity of the disease and the intensity of liver damage. Sometimes, even a CT scan or Ultrasound abdomen scan can be recommended for examining the stiffness of the liver. WHAT IS WORLD LIVER DAY?   Every year on April 19, the World Liver Day (WLD) is observed to promote awareness of liver disease among the general population. According to the World Health Organisation, liver disorders account for 3.17% of all fatalities in India, which is approximately 268,580 populations. World Liver Day is an excellent initiative encouraging people to learn more about liver health.    5 THINGS YOU NEED TO KNOW ABOUT THE LIVER    The liver is the second-largest organ in our body. On this World Liver Day, let's educate ourselves about the importance of this organ, as it plays a crucial role in various bodily functions.   1. Helps in controlling blood sugar levels by converting excess blood glucose to glycogen 2. Aids in digestion by producing bile and helps the metabolism of fats, medications and alcohol. 3. Helps in the detoxification of all the toxic substances from the body. 4. Responsible for the synthesis of heme and blood-clotting factors. 5. Involved in the storage of vitamins and minerals.   Do you know?  According to the WHO, it has been reported that liver diseases are among the top 10 [https://www.worldlifeexpectancy.com/india-liver-disease] causes of death in India. Liver diseases are generally referred to as “silent diseases” because the liver has the potential to tolerate all the stress until it reaches a point of irreversible, permanent damage and stops functioning.    8 DANGEROUS TYPES OF LIVER DISEASES 1. Alcoholic liver disease: It is caused due to chronic alcoholism and occurs in three different stages namely the initial stage is liver steatosis or simple fatty liver, the second stage is alcoholic hepatitis which causes inflammation of the liver. Alcoholic hepatitis further leads to a life-threatening condition called alcoholic cirrhosis, the final stage where most of the liver cells get degenerated. 2. Viral hepatitis: It is an infection that causes inflammation of the liver. Viral hepatitis [https://www.mrmed.in/health-library/viral-infections/all-about-viral-hepatitis] can be  caused by five types of viruses, namely hepatitis A,B,C,D and E virus. Viral hepatitis is highly contagious and occurs due to consuming contaminated food, water and unprotected sexual practices. However, hepatitis B is the most common among them and it lasts longer than six months. 3. Liver cirrhosis: It is a condition where healthy liver tissues are replaced with scarred liver tissues due to excessive damage. 4. Drug-induced liver failure: It is caused by a lot of medications such as NSAIDs like paracetamol, antituberculosis drugs, vitamins, herbal supplements and a few antibiotics that can cause detrimental effects to the liver due to overdose. 5. Nonalcoholic liver disease: It is also referred to as “Fatty Liver,” occurs as a result of excessive build-up of fat ( > 5%) in the body. It is also related to obesity and type 2 diabetes. 6. Autoimmune liver disease: It happens when our own immune system attacks our healthy liver cells by either causing damage to bile ducts or resulting in inflammation. The three common autoimmune liver diseases are autoimmune hepatitis, primary biliary cholangitis and sclerosing cholangitis.  7. Inherited liver diseases: They are genetic liver disorders that occur due to the hereditary accumulation of either copper or iron in the body that causes Wilson’s disease and hemochromatosis, respectively. 8. Liver cancer: It begins in liver cells when abnormal cells multiply and form tumour cells. Hepatocellular carcinoma is the common type of liver cancer. The risk of liver cancer is more common in those with liver cirrhosis and those drinking large amounts of alcohol and have a high build-up of fat in the liver INDIA'S LIVER WELLNESS JOURNEY: WORLD LIVER DAY 2024! World Liver Day 2024 has the theme "Keep your liver healthy and disease free" The topic emphasises the importance of routine liver exams because anyone can develop fatty liver, regardless of risk factors like obesity (overweight), insulin resistance (diabetes), and excessive alcohol intake. Recent studies conducted in India have revealed that patients with low body mass indices (25 kg/m2) account for 75% of cases of non-alcoholic fatty liver disease (NAFLD; liver disease caused in people who drink little to no alcohol).   WHAT IS THE IMPORTANCE OF WORLD LIVER DAY   Cirrhosis-related causes account for just half of the 20 lakh deaths per year from liver illnesses worldwide; the other half is attributable to viral hepatitis and hepatocellular (liver) carcinoma. Lack of knowledge regarding the severity of the disease, associated risk factors, and prevention is the cause of the increase in the numbers. On this day, leaders in the hepatological community, including private hepatologists, hepato-oncologists, and healthcare officials, speak to the public about the danger of liver disease [https://www.mrmed.in/health-library/liver-care/liver-disease-awareness] and ways to prevent it, such as dietary changes and ways of life adjustments. The WLD also gives participants a chance to learn more about the signs and symptoms of liver disease and the significance of early detection, as most liver disorders are asymptomatic.   WHAT ARE THE POSSIBLE TREATMENT PLANS TO MANAGE LIVER DISEASES?   Generally, the treatment is based on the type of disease   1. Doctors may prescribe antibiotics/antiviral agents in case of treating hepatitis. 2. Strict lifestyle modification and diet plan [https://www.mrmed.in/health-library/liver-care/liver-disease] is needed to manage liver diseases such as cutting down salt intake and refraining from alcohol and high fatty foods. 3. A liver transplant will be considered for those with end-stage liver diseases or liver cancer; where the diseased liver can be replaced with a healthy liver.   TIPS TO KEEP YOUR LIVER HEALTHY   Love Your Liver And Live Longer   Keeping your liver in proper shape will help to prevent liver diseases.  On this World liver day 2024, let's have a determination to take regular health check-ups to avoid any kind of liver disease.   * To maintain your normal BMI and prevent conditions like fatty liver, it is imperative to perform regular physical exercise that involves cardio, strength and stretching. * Eat a balanced diet rich in fiber. Get vaccinated if you are at high risk of contracting hepatitis [https://www.mrmed.in/health-library/viral-infections/what-are-antiviral-drugs] or having a history of hepatitis infection. * Avoid taking over-the-counter medicines because consuming inappropriate doses can cause excessive liver damage. * Limit alcohol consumption and quit smoking. Keep your blood glucose levels under control. Be aware during blood transfusion, to prevent contracting hepatitis infection. * Get periodic checkups to know the status of your liver enzymes and functions.
Ishwarya R
Immunotherapy For Liver Cancer
28 Oct 2023
10 mins
Immunotherapy For Liver Cancer"We have two options, medically and emotionally: give up or fight like hell."   Today, we are going to see the most important tool that boosts our immune system to fight against liver cancer cells, which is nothing but immunotherapy [https://www.mrmed.in/health-library/cancer-care/cancer-immunotherapy]. Treating liver cancer is not as simple as we think, but we use an advanced treatment like immunotherapy, which can treat complex liver cases with minimal side effects compared to others. Let's explore more about the essence of immunotherapy in treating liver cancer in this blog.   IMMUNOTHERAPY: A SAVIOUR AGAINST LIVER CANCER   Our immune system is the best defense force in our body; by triggering this, we can defeat the most dangerous killer, liver cancer. This can be achieved by medicines that help a patient's own immune system find and destroy cancer cells. Immunotherapy is an emerging liver cancer treatment [https://www.mrmed.in/health-library/liver-care/liver-cancer-treatment] that stimulates your immune system to fight against the deathly cancer cells in the liver. It is used to treat patients with advanced liver cancer stage (metastatic) and whose health condition is not able to support surgery.    IMMUNOTHERAPY FOR METASTATIC LIVER CANCER   Immunotherapy is effective against metastatic (secondary) liver cancer. Metastatic cancer is a type of cancer that spreads from where it started to a distant part of the body; it is also called stage IV (4) cancer. This process of spreading cancer cells to other parts of the body is called metastasis. Immunotherapy has given a promising treatment for reversing these conditions and is considered a revolutionary treatment for the metastasis of liver cancer.   EFFECT OF IMMUNOTHERAPY IN LIVER CANCER   * It increases the rate of survival of liver cancer patients. * It gives long-term cancer control for patients who are suffering from liver cancer. * It minimizes the risk of side effects caused by other cancer treatments (chemotherapy, surgery). * Immunotherapy is the best option for treating liver cancer in patients with health complications (some patients' health does not support surgery, or the severity of the disease is too high to treat it). * Chemotherapy drugs can also affect nerve control in individuals (loss of sensation). In that case, immunotherapy is the best option to treat patients with nerve problems.   TYPE OF IMMUNOTHERAPY   Cancer can be treated by different types of immunotherapy based on the type and severity of the cancer. Some of the types of immunotherapy are given below:   * Immune checkpoint inhibitors: Their main role is to prevent an immune response that destroys healthy cells in the body. It inhibits the checkpoint protein (PD-L1,  CTLA-4) binding with the partners. * Monoclonal antibodies: Monoclonal antibodies are proteins, artificial or man-made antibodies, meant to stimulate your immune system. * Treatment vaccines: They stimulate the immune system to attack and recognize cancer cells and also train your body to fight against it. * Immune system modulators: They increase T cell growth factor levels that play a significant role in attacking the cancer cells and destroying them. * Adoptive cell therapy (T-cell transfer therapy): It involves collecting a patient's immune cells, especially T cells, and improvising them in the laboratory to fight against cancer and then incorporating them again into the patient's body.   BEST IMMUNOTHERAPY FOR LIVER CANCER   Among the five types of immunotherapy treatment, immune checkpoint inhibitors are the commonly used immunotherapy against liver cancer. According to studies, the combination of atezolizumab [https://www.mrmed.in/molecule/atezolizumab]-bevacizumab [https://www.mrmed.in/molecule/bevacizumab] drugs gives the best result for treating liver cancer by immunotherapy.   IMMUNOTHERAPY SUCCESS RATE FOR LIVER CANCER   According to the Asian Institute of Gastroenterology (AIG), the combination of atezolizumab-bevacizumab immunotherapy drugs can completely resolve the tumor in 12.9 percent of liver cancer patients and partially resolve 25.8 percent of liver cancer patients. The The overall survival rate of immunotherapy [https://www.financialexpress.com/healthcare/pharma-healthcare/immunotherapy-combination-extends-liver-cancer-patients-survival-reveals-study/3244227/] for liver cancer patients who have good liver function is 21 months.   SIDE EFFECTS OF IMMUNOTHERAPY FOR LIVER CANCER   Immunotherapy can cause side effects due to the immune response against the cancer and also acts against healthy cells.   * Pain: Most of the people experience pain in the upper right quadrant. If you experience any pain during or after cancer treatment, tell your doctor. * Swelling: Checkpoint inhibitors induce an immune response that can cause redness and swelling in the body. * Fluid retention: You may experience edema after immunotherapy or weight gain due to the accumulation of fluid. * Diarrhea and colitis: Diarrhea is the common symptom most of people experience during the treatment, which is caused by the inflammation of the colon (colitis). * Infection: Infections are common in CAR T-cell therapy due to the weakening of infection-fighting immune cells. * Organ inflammation (liver inflammation): Even though immunotherapy is meant to help your immune system fight against cancer cells, the immune cells mistakenly attack healthy tissue, which leads to inflammation of the liver. * Elevation of liver or pancreatic enzymes: You may have an increased liver enzyme ( alkaline phosphatase, alanine transaminase, aspartate aminotransferase, and gamma-glutamyl transferase) or pancreatic enzymes (lipase, protease, and amylase).   RECENT RESEARCH IN IMMUNOTHERAPY FOR LIVER CANCER   An Australian research center (Peter Mac) has identified a new type of immunotherapy [https://www.petermac.org/about-us/news-and-events/news/details/researchers-uncover-a-new-type-of-immunotherapy-to-treat-cancer#:~:text=Researchers%20at%20Peter%20Mac%20have,first%20drug%20that%20targets%20mRNA] that uses a drug targeting mRNA. It fools the cancer cells and helps our immune system to destroy it. They found that the inhibition of the certain enzyme (METTL3) in cancer cells triggers the immune system to kill the cancer cells, which resemble the structure of viruses. This strategy is more effective when we combine this with immune checkpoint inhibitors for treatment.   FAQ   What is the success of immunotherapy on liver cancer? Even though only 15 to 25 percent of patients show a response to immunotherapy for liver cancer, it is the most effective treatment for patients who are in an advanced liver cancer stage.   Is everyone eligible for immunotherapy treatment for liver cancer?  However, immunotherapy is the best option to treat advanced liver cancer (hepatocellular carcinoma). It is not a good option for early liver cancer. Your doctor will decide and recommend the appropriate type of treatment based on the stage of cancer.   What do I need to follow while under immunotherapy treatment for liver cancer? Your body needs proper rest while under immunotherapy medication. So, always remember to take enough rest for a speedy recovery. Eat a nutritional-rich diet and stay hydrated. Make sure that you always connect with your doctor during the treatment and after the treatment.   Can I experience hair fall while under immunotherapy treatment? You may experience hair thinning during immunotherapy treatment due to an immune response against the healthy hair cells. Treatments like chemotherapy may cause intense hair fall compared to other cancer treatments.   END-NOTES!   I hope everyone who reads this blog knows that we can win the battle of liver cancer easily with the powerful tool of immunotherapy. Use this tool wisely by following the essential notes that are mentioned in this blog. Always remember to speak with your doctor for the best choice of treatment based on your liver cancer stage and your health condition. Research and development help us to overcome the side effects caused by immunotherapy so that we can use this beneficial tool in a better way.   "Being positive is the best medicine you can take."
Dr Archana Gupta
What Are The Treatment Options For Liver Cancer?
23 Oct 2023
9 mins
What Are The Treatment Options For Liver Cancer?"Every person with liver cancer deserves the dignity of the best standard of care."   Amidst the labyrinth of challenges in liver cancer, the beacon of hope lies in the dynamic world of treatment strategies. With its intricate web of surgical marvels, cutting-edge therapies, and compassionate care, the field of liver cancer [https://www.mrmed.in/health-library/liver-care/liver-cancer] treatment is continuously evolving. In this blog, let's explore the essentials of liver cancer treatment and its type, side effects, and survival rate.   WHY SHOULD WE SAFEGUARD OUR LIVER?   Your liver is a vital organ in your body responsible for most of the important functions like metabolism, immunity, digestion, detoxification, and storage of vitamins. The liver is the major role player in nearly every organ system in the body by interacting with the endocrine and gastrointestinal systems (digestion and metabolism). It acts as a bridge to transfer the nutrients into our bloodstream.   MANAGING LIVER CANCER: EXPLORING TREATMENT OPTIONS   The treatment of liver cancer depends [https://www.cancer.gov/types/liver/what-is-liver-cancer/treatment#:~:text=Surgery,the%20liver%20and%20may%20regrow]on the type and stage of cancer and the medical history of the patient. It's essential to consult with a doctor to determine the most suitable treatment plan that fits your health. It can be broadly classified into surgical and non-surgical approaches. It has different treatment measures, which are given below:   SURGICAL TREATMENT AND RECOVERY   It is used to remove a well-grown solid tumor in a particular place of the liver. Resection and liver transplantation are two surgical options that help to treat liver cancer, and after the surgery, it takes some time to heal the wounds caused by surgery. So, If you plan to go for surgery as an option, always remember to give enough rest to the body. After every surgery, our body needs a period of recovery. How long this takes will depend on your age, the type of surgery you had, and your overall fitness and health. It may take a few days or a week to recover from a small operation, but it can take a few months for a large procedure.   Resection: Surgical resection involves the removal of the liver tumor along with a healthy portion of liver tissue. It is suitable only when the cancer is specific to a particular area of the liver and has not spread to any other parts of the body.   Liver Transplant: Liver transplantation is surgery to remove the cancer-affected liver and replace it with a healthy liver (donor). It is suitable for patients with early-stage liver cancer and underlying liver disease. It may not be possible for individuals with metastatic cancer (spreading of cancer from one part to another part of the body).   POST-SURGERY PROTOCOL: 5 ESSENTIAL STEPS FOR A SMOOTH RECOVERY   1. Most patients will need a high level of care (you will spend at least 5–10 days in the hospital after a liver resection), and your doctor will decide whether to keep you in special care like ICU (intensive care unit), and the duration of the stay. 2. Stay connected with your healthcare provider after surgery (follow-up visit) and Inform your doctor immediately if you face any trouble or infection after the surgery. 3. Avoid or limit drinking alcohol and eat a healthy diet to boost your immune system. 4. The risk of raising an immune response against the donor's liver is high (graft rejection); hence, it is essential to be cautious for at least six months. 5. Immunosuppressive drugs like azathioprine [https://www.mrmed.in/molecule/azathioprine], cyclophosphamide [https://www.mrmed.in/molecule/cyclophosphamide], and cyclosporine [https://www.mrmed.in/molecule/cyclosporine] can be used to prevent rejection of organs and treat infection and complications caused by liver transplantation.   NON-SURGICAL LIVER CANCER TREATMENT   If the patient's health condition does not support surgery, then the doctor will suggest non-surgical liver cancer treatments, like radiation therapy [https://www.mrmed.in/health-library/cancer-care/cancer-treatment-using-radiation-therapy], ablation therapy, chemotherapy [https://www.mrmed.in/health-library/cancer-care/chemotherapy-myths-and-facts], target therapy, and immunotherapy, are the best options for treating liver cancer. Individuals with advanced stages of liver cancer and multiple tumors can be recommended to go for non-surgical treatment by their doctor.   * Radiation Therapy: Radiotherapy uses high-energy rays to kill the tumor cells. It can be delivered externally or internally. SIRT (Selective Internal Radiation Therapy) may be recommended for older patients whose livers are not severely damaged, and surgery is not applicable. * Ablation Therapy: Ablation Therapy uses techniques that involve radiofrequency ablation (RFA), microwave therapy, and ethanol or cryoablation to kill tumors without surgery. * Chemotherapy: Chemotherapy involves drugs to kill the cancer cells, and it can be administered either orally or intravenously. Transarterial chemoembolization (TACE) is a type of chemotherapy that directly targets liver tumors. * Targeted Therapy: Target therapy involves drugs that specifically target abnormal cancer cells and are designed to interfere with the growth and spread of affected cancer cells. * Immunotherapy: Immunotherapy boosts our body's immune system to help fight against cancer. Some immunotherapy drugs for liver cancer treatment are atezolizumab [https://www.mrmed.in/molecule/atezolizumab], durvalumab (Imfinzi) [https://www.mrmed.in/molecule/durvalumab], and pembrolizumab (keytruda) [https://www.mrmed.in/molecule/pembrolizumab]. * Embolization Therapy: Embolization Therapy blocks or limits the blood flow to the tumor by delivering the radioactive particles through tubing (catheter) into the arteries of the liver tumor.   SUCCESS RATE OF LIVER CANCER TREATMENT   The rate of survival after liver cancer treatment [https://www.cancer.org/cancer/types/liver-cancer/detection-diagnosis-staging/survival-rates.html] is high if the individual has had surgery to remove their cancer. For patients with early-stage liver cancers who are treated with a liver transplant, the 5-year survival rate is in the range of 60% to 70%.   SIDE EFFECTS OF LIVER CANCER TREATMENT   Even though the treatment of liver cancer has a lot of benefits, it also can cause side effects like other treatments. The side effects usually depend on the type of treatment and individual health condition. Some of the liver cancer treatment side effects are given below:   * Fatigue: It is the most common side effect. Even healthy people and individuals who are under any cancer treatment can also face this. * Pain: You can experience some pain at the surgery place. * Low blood count: Individuals under chemotherapy treatment have a side effect of low red and white blood cells. * Nausea: It is a very common side effect of chemotherapy treatment. * Sleep disorder: Patients who are under liver cancer treatment may face sleep disorders. * Nerve disorder: Chemotherapy drugs can also affect nerve control in individuals (loss of sensation).   WRAP IT UP!   The treatment of liver cancer is a multifaceted process that needs a complete approach. Make a note of this and use the various available treatments, such as surgery, radiation therapy, chemotherapy, targeted drug therapy, immunotherapy, and ablation or embolization therapy, in a well-planned way. Liver cancer is not a deathly disease if you use treatment as a proper tool.   "Keep shining brightly even in the darkest times"
Dr Archana Gupta
Liver Cancer
4 Oct 2023
9 mins
Breaking Barriers: The Battle Against Liver CancerYou can be a victim of cancer or a survivor of cancer. It's a mindset.   Today, we will discuss the most common and dangerous disease affecting our one-man army “liver". Liver cancer is the 6th most commonly affecting cancer worldwide, the 5th most common cancer in men, and the 9th most common cancer in women. We ensure proper protection against this killer disease. Let's know more about it!   KNOW ABOUT LIVER CANCER   Your liver is placed on the right side of your abdomen which is crucial in removing the toxic substance from your body. When cancer cells develop in the liver tissue, it results in the cancer of the liver. Keep reading to know more about liver cancer!   Types Of Liver Cancer   It can be categorized into two: Primary and secondary liver cancer [https://www.cancerresearchuk.org/about-cancer/liver-cancer/types]. Primary cancer starts where the cancer first develops, and secondary cancer is caused by the primary cancer cells breaking down from other parts of the body (metastasis). Primary liver cancer has five types which are given below: * Hepatocellular carcinoma (HCC) * Fibrolamellar carcinoma (FLC) * Cholangiocarcinoma (bile duct cancer) * Angiosarcoma * Hepatoblastoma Symptoms Of Liver Cancer   Liver cancer may have symptoms, but some of them may not show any symptoms. The symptoms for both [https://www.nhs.uk/conditions/liver-cancer/symptoms/] primary and secondary cancer are the same, which are given below: * Jaundice: Yellowish skin and eyes. * Abdominal Pain: Discomfort or pain in the right side of the upper abdomen. * Unexplained Weight Loss: Sudden and unexplained loss of weight in the body. * Fatigue: Continuous tiredness and weakness. * Loss of Appetite: Loss or decrease in appetite and feeling fullness. * Swelling: Abdominal swelling or accumulation of fluids (ascites). * Nausea and Vomiting: Nausea and vomiting (sometimes blood vomiting). * Change in Stool Color: Light-colored or bloody stools.   Causes Of Liver Cancer   The causes of primary liver cancer [https://www.cdc.gov/cancer/liver/index.htm#:~:text=Liver%20cancer%20can%20be%20caused,through%20use%20of%20shared%20equipment.] is due to many reasons, but the cause of secondary liver cancer is unknown. Some of the causes for primary liver cancer are given below: * Being overweight (obesity) * Long-term hepatitis B virus or hepatitis C virus infection. * Smoking cigarette * Drinking alcohol * Liver cirrhosis [https://www.mrmed.in/health-library/liver-care/liver-disease-awareness] (damaged and scarred liver) * Nonalcoholic fatty liver disease (extra fat in the liver) * Diabetes * Hemochromatosis ( the body takes up and stores more iron than it needs) * Eating foods contains aflatoxin (a fungus that can grow on grains and nuts)   LIVER CANCER TREATMENT   The treatment for liver cancer [https://www.nhs.uk/conditions/liver-cancer/treatment/#:~:text=For%20liver%20cancer%2C%20the%20chemotherapy,control%20and%20improve%20the%20symptoms.] is determined by many factors, such as whether it's primary or secondary, the tumor's size and type, location and intensity of spreading, and the overall health of the patient. Early communication with your doctor is important for effective treatment and management of the disease. The treatment options include surgery, chemotherapy, thermal ablation, targeted medicines, and radiotherapy.   Surgery   If it is detected in the starting stage, when it's small and not yet spread, surgery may be an option for removal. This includes a partial or complete removal of the liver, with a liver transplant being necessary if the entire organ is removed, and the recovery after the surgery always takes time.    Transplantation   A liver transplant involves removal of  diseased or damaged liver and replacement with a healthy one (donar) and this is recommended for liver failure or end-stage patients. Unlike other organs (the kidney, heart, or lungs) there is no available device or machine (dialysis machine) that can effectively replicate the function of the liver. So transplantation is the only ray of hope for them.   Chemotherapy   Chemoembolization, a method of delivering chemotherapy medication directly into the cancer blood vessels to inhibit the growth of the cancer, is often used to shrink tumors, reduce symptoms, or manage situations where surgery is not feasible due to health concerns or tumor location.   Thermal ablation   Thermal ablation involves electric current or microwaves to destroy it, typically used when surgery is not a good choice for a patient's health.   Target Therapy   Target therapy is specifically designed to block the growth of the liver cancer. These medications are considered for the treatment in cases where surgery is not working due to the patient's poor health or if the cancer has spread to another part of the body.   Radiotherapy   Radiotherapy, a treatment employing radiation to kill the cancer cells. Selective Internal Radiation Therapy (SIRT), a specific form of radiotherapy, involves the injection of radioactive beads into the blood supply of the liver to destroy cancer growth. SIRT may be recommended for adult patients whose livers are not severely damaged, and surgery is not applicable.   LIVER CANCER PREVENTION MEASURES   You can prevent or decrease your risk of developing liver cancer in an easy way, such as healthy lifestyle measures, regular exercise, maintaining your weight, eating a diet which is healthy [https://www.mrmed.in/health-library/liver-care/liver-disease] for your body, and most importantly, avoiding or limiting alcohol consumption. It is also important to protect you from hepatitis B and C viruses by vaccination.   SURVIVAL RATE   Survival rate can give you a better idea of the percentage of people with the same type and stage of cancer who are still alive in a certain time period (usually five years) after they were diagnosed. This survival can't tell you how long you will live, but it may help give you an understanding of the success of the treatment.   Make a note that survival rates are estimates and are often based on past outcomes of a large group of the population who had a specific type of the disease. The survival rate for the [https://www.rgcirc.org/blog/survival-rate-patients-suffering-liver-cancer/] five years is 33%, in which the people are diagnosed at an initial stage. Suppose it has already started affecting the surrounding tissues or organs, the survival rate for five years decreases to 11%, and it even falls to 2% if the cancer has spread to another body part.   Let's Take A Pledge   I hope this blog is helpful to know more about liver cancer and its symptoms, causes, treatment, and prevention measures. It is a challenging disease that can have an intensive impact on the health and well-being of an individual. It always develops silently, with few noticeable symptoms in its starting stages, making early disease detection is crucial for effective treatment. Today, we pledge to rise against this deadly disease and increase the survival rate of liver cancer patients.
Dr Archana Gupta