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5FU GLS 250mg Injection
Last updated on 31 Mar 2026 | 09:30 AM (IST)
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5FU GLS 250 mg Injection is a prescription anticancer medicine used to treat various cancers, including colorectal, breast, and stomach cancer. It contains fluorouracil, which works by stopping cancer cells from growing and multiplying. It is given under strict oncologist supervision as part of chemotherapy.
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Introduction to 5FU GLS 250mg Injection
5FU-GLS 250mg Injection contains the active ingredient Fluorouracil. It belongs to a class of drugs called antimetabolites, which interfere with the genetic material (DNA and RNA) synthesis of rapidly dividing cancer cells, leading to their death. This medication is commonly used to treat breast, colorectal, stomach, esophagus, and pancreatic cancers. It can be administered in different ways, including through injection or as a cream.Â
Like all other anticancer medications, 5FU-GLS 250mg Injection can cause side effects. Common side effects are nausea, vomiting, diarrhea, mouth sores, hair loss, and an increased risk of infection. However, not all patients will experience these side effects, and the severity of the side effects can vary from person to person. No specific foods need to be avoided when receiving them. Still, alcohol, spicy or acidic foods, citrus fruits and juices, and high-fiber foods may worsen some side effects, such as nausea, vomiting, mouth sores, and gastrointestinal problems. Patients should consider avoiding or limiting these foods during treatment. Inform your physician before starting this treatment if you have undergone surgery in the last 30 days or are following a controlled sodium diet.
Uses of 5FU GLS 250mg Injection
5FU-GLSÂ 250mg Injection is used to treat
- Colon and rectum cancer
- Breast cancer
- Gastric cancer
- Pancreatic cancer
- Head and Neck cancers
- Esophagus cancer
- Anal cancer
- Bladder cancer
Therapeutic Effects of 5FU GLS 250mg Injection
5FU-GLS 250mg Injection works by interfering with the DNA and RNA synthesis of rapidly dividing cancer cells, leading to their death. It is an antimetabolite chemotherapy drug that mimics the structure of normal DNA and RNA building blocks. Still, its incorporation into DNA and RNA leads to errors in formation and causes damage to the DNA and RNA strands.
Interaction of 5FU GLS 250mg Injection with other drugs
Inform your healthcare provider about all your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with 5FU-GLS 250mg Injection and reduce effectiveness by causing undesirable side effects.
More Information about 5FU GLS 250mg Injection
- 5FU-GLS 250mg Injections should be stored in a refrigerator between 2-8°C (36-46°F) and protected from light. It should not be frozen.
- The cream should be stored at room temperature (between 20-25°C or 68-77°F), away from heat and light. It should not be frozen.
- Unused injection portions should be disposed of properly and not kept for future use.
- Patients should not handle or come into contact with it without appropriate protective equipment, as medication can harm the skin and eyes.
- Keep dry and protected from light and moisture.
- Kept in the original package when not in use.
- Keep it out of reach from children and pets.
How to consume 5FU GLS 250mg Injection
5FU-GLS 250mg Injection is a medication typically administered under a healthcare provider's supervision, usually in a hospital or clinic setting. The method of administration can vary depending on the type of cancer and the individual patient's condition. The injection can be given in a vein (intravenous) or muscle (intramuscular) injection. If a patient misses a scheduled dose, they should contact their healthcare provider immediately to determine the next steps. Sometimes, the missed dose may be rescheduled, or a new treatment plan may be recommended. It is important to follow the healthcare provider's instructions closely and not make any changes to the treatment plan without first consulting with them. Patients should never take a double dose to make up for a missed dose, as this can increase the risk of side effects and toxicity.
Safety Advice for 5FU GLS 250mg Injection
Breast Feeding
It is unknown whether it is excreted in human milk or not. So breastfeeding women should discuss with healthcare professionals before the treatment.
Alcohol
5FU-GLS 250mg Injection has been associated with some lung-related side effects, although these are relatively uncommon. Consult your doctor if you have any lung diseases before starting the treatment.
Liver
Regular monitoring of liver function tests is recommended because 5FU-GLS 250mg Injection has been associated with liver injury in some patients. It is important to monitor liver function regularly in patients, particularly in those with pre-existing liver disease or a history of liver problems.
Lungs
5FU-GLS 250mg Injection has been associated with some lung-related side effects, although these are relatively uncommon. Consult your doctor if you have any lung diseases before starting the treatment.
Driving
It is generally recommended that patients taking 5FU-GLS 250mg Injection avoid or limit their alcohol intake, as alcohol can increase the risk of liver damage and exacerbate any liver-related side effects.
Pregnancy
5FU-GLS 250mg Injection is unsafe for pregnant women as it may cause fetal harm. So it is not recommended to take it during pregnancy.
Side Effects of 5FU GLS 250mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious:
- Severe chest pain
- ECG abnormalities
- Anemia
- Severe allergic reactions
- Blood in stool
- Mouth sores
- Numbness, tingling, and tremors of hands and feet
- Rapid heart rate
- Leukoencephalopathy symptoms
- Breathlessness
Common:
- Low WBC count, fever
- Weakness
- Nausea, vomiting
- Inflammation in the mouth
- High uric acid levels in the blood
- Nosebleeds
- Muscle pain
- Hair loss
- Loss of appetite
- Watery diarrhea
- Bone marrow problems
- Thyroid disorders
- Infections
Word of Advice
If you have been prescribed 5FU-GLS 250mg Injection for cancer treatment, it is important to take your medication exactly as prescribed by your healthcare provider. It is also important to be aware of the potential side effects of injection, ranging from mild to severe. If you experience any new or worsening symptoms, report them to your healthcare provider immediately. Women of childbearing age should use effective birth control during treatment and afterward, as the injection can harm a developing fetus.
 If you are pregnant or breastfeeding, discuss the risks and benefits of medication with your healthcare provider. Additionally, patients with liver or kidney disease may require lower doses or more frequent monitoring of liver function during treatment. Regular blood and other monitoring tests are required to evaluate the effectiveness of the treatment. With careful monitoring and communication, your healthcare provider can help you navigate any challenges or concerns during treatment.
FAQs about 5FU GLS 250mg Injection
Q1.
What is the usual 5FU-GLS 250mg injection dosage for cancer treatment?
The 5FU-GLSÂ 250mg Injection dosage depends on several factors, including the type of cancer being treated, the patient's age and weight, and overall health.
Q2.
How is 5FU-GLSÂ 250mg Injection different from other chemotherapy medications?
5FU-GLSÂ 250mg Injection is a type of chemotherapy medication known as an antimetabolite, which works by interfering with the DNA replication process in cancer cells.
Q3.
Can 5FU-GLSÂ 250mg Injection be combined with other cancer treatments?
Yes, 5FU-GLSÂ 250mg Injection can be combined with other chemotherapy medications, radiation therapy, and targeted therapies for certain types of cancer.
Q4.
Are any foods or medications that should be avoided while taking 5FU-GLSÂ 250mg Injection?
Some foods and medications, including herbal supplements and over-the-counter pain relievers, can interact with 5FU-GLSÂ 250mg Injection and increase the risk of side effects. Discussing all medications and supplements with your healthcare provider before starting treatment is important.
Q5.
How effective is 5FU-GLSÂ 250mg Injection at treating cancer?
5FU-GLSÂ 250mg injection's effectiveness in treating cancer depends on several factors, including the type and stage of the cancer being treated and the individual patient's response to the medication. It is important to discuss treatment options and expectations with your healthcare provider.
Q6.
What should I do if I experience severe side effects from 5FU-GLSÂ 250mg Injection?
If you experience severe side effects from 5FU-GLS 250mg Injection, such as fever, severe nausea or vomiting, or signs of infection, it is important to contact your healthcare provider immediately.
Q7.
Can 5FU-GLS 250mg Injection cause a sunburn-like reaction on the skin?
Yes, 5FU-GLSÂ 250mg Injection can cause a sunburn-like reaction on the skin, especially when used topically to treat certain skin cancers. This reaction can cause redness, itching, burning, and peeling of the skin, lasting for several weeks. Patients should avoid exposure to sunlight and wear protective clothing and sunscreen while receiving treatment with this injection to minimize this side effect.
Q8.
Can 5FU-GLSÂ 250mg Injection cure cancer?
5FU-GLS 250mg Injection can effectively treat certain types and stages of cancer, but it is not a cure. Its ability to shrink or slow the growth of tumors depends on various factors, including the type of cancer, its stage, and the patient's overall health.
Fact Box of 5FU GLS 250mg Injection
Molecule name: Fluorouracil | Therapeutic class: Anticancer |
Pharmacological class: Antimetabolites | Indications:Â 1. Colon and rectum cancer 2. Breast cancer 3. Gastric cancer 4. Pancreatic cancer 5. Head and Neck cancers 6. Esophagus cancer 7. Anal cancer 8. Bladder cancer |
References
- Accord Healthcare Limited, Electronic Medicines Compendium (EMC), [Last Revised], [Accessed 1, April 2023, 2023].https://www.medicines.org.uk/emc/product/9049/smpc
- DeVita, Hellman, and Rosenberg's Cancer: Principles and Practice of Oncology, 11th edition, 2019, 573-582.
- Goodman & Gilman's The Pharmacological Basis of Therapeutics, 13th Edition, 2018, 2017, 1317-1322
- KD Tripathi, Anticancer Drugs, Essentials of Medical Pharmacology, 8th Edition, 2019, 915-936
Disclaimer
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Author Details
Written By
Dr. Bhairavi S
Pharm. D
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 31 Mar 2026 | 09:30 AM (IST)
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