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28% Off

Abakast L Tablet

Prescription Required

Salt Composition : Abacavir,lamivudine

Manufacturer : APRAZER HEALTHCARE PVT LTD

Origin of Medicine : India

MRP: 2900
Price :2100
You Save :800 (28%)

30 Tablet(s) In A Bottle


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Introduction to Abakast L Tablet

Abakast L Tablets is an antiretroviral medication containing the active constituents Abacavir and Lamivudine. Both medications belong to a class of drugs called nucleoside reverse transcriptase inhibitors (NRTIs) and are often used in combination with other antiretroviral drugs as part of highly active antiretroviral therapy (HAART) or combination antiretroviral therapy (cART). It is used to treat HIV-1 infection. HIV-1 is a virus known as the Human immunodeficiency virus, which targets and eradicates immune system cells, ultimately weakening the body's defense against infections. If left untreated, it can result in death. While this medication does not offer a complete cure, it effectively lowers the virus levels in your body and boosts the count of CD4 cells in your bloodstream. These cells play a crucial role in assisting your body's fight against infections.

Abakast L Tablets are usually given with other medicines to treat HIV infection. Combining Abakast L Tablets with didanosine is not advisable, as it could raise the chances of experiencing didanosine toxicity. Before taking this medication, it is important to inform your doctor if you have any liver disease, including hepatitis B or C, kidney disease, heart problems, high blood pressure, high cholesterol, diabetes, or if you are overweight. It is crucial not to share personal items like razors or toothbrushes with others, and breastfeeding should be avoided. Consult your doctor for guidance on practicing safe sex. The administration of this medicine can potentially result in lactic acidosis, which involves the accumulation of acid in the bloodstream. In individuals with advanced HIV infection and severely compromised immune systems, initiating antiretroviral therapy, including Abakast L Tablets, may lead to an inflammatory response known as immune reconstitution inflammatory syndrome. Close monitoring is necessary in such cases.


Uses of Abakast L Tablet

  • Treatment of HIV – 1 infection

Therapeutic Effects of Abakast L Tablet

Abakast L Tablets work by inhibiting the reverse transcriptase enzyme, which is necessary for the replication of HIV. By blocking this enzyme, the drugs help to reduce the viral load in the body, slow down the progression of HIV infection, and improve the immune system's function.


Interaction of Abakast L Tablet with other drugs

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. Certain medications interact with Abakast L Tablets and reduce their effectiveness by causing undesirable side effects.


More Information about Abakast L Tablet

  • Store at controlled room temperature, between 20°C to 25°C (68°F to 77°F).
  • Protect the medicine from light and excessive moisture.
  • Keep the medicine out of reach of children and pets
  • Take only a partial dose to compensate for a forgotten dose.

How to consume Abakast L Tablet

To use Abakast L Tablets, follow the prescribed dosage and instructions provided by your healthcare provider. Take the medications as directed, usually orally, with or without food. Do not skip doses or stop taking them without consulting your healthcare provider. Consult your healthcare provider or pharmacist for guidance if you have any questions or concerns.


Safety Advices for Abakast L Tablet

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Pregnancy

  

Abakast L Tablets may cause harm to an unborn baby. Inform your doctor if you are pregnant or planning to get pregnant before taking it. The doctor will explain the potential risks and benefits.

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Breast Feeding

  

Breastfeeding is not recommended because the viral infection can pass through breast milk while taking Abakast L Tablets.

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Lungs

  

It is important to discuss your specific lung condition with your healthcare provider, as they can provide personalized advice based on your medical history and individual needs.

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Liver

  

Abakast L Tablets should be used cautiously in individuals with liver impairment or pre-existing liver disease. This is because this medication is primarily metabolized in the liver, and impaired liver function can affect the metabolism and clearance of the medication from the body.

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Alcohol

  

It is unsafe to drink alcohol while taking Abakast L Tablets. It may reduce the drug's effectiveness and can cause toxic side effects. 


 

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Driving

  

Abakast L Tablets can cause dizziness. It is recommended to avoid driving and operating heavy machinery during the treatment. 


 


Side Effects of Abakast L Tablet

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.


 

Serious


 

  • Lactic acidosis (breathing difficulties along with weakness in limbs, stomach pain, vomiting, drowsiness)
  • Liver problems (yellowing of whites of eyes and skin, urine turns dark, light-colored stools)
  • Severe allergic reactions (fever, rash, nausea, diarrhea, shortness of breath)
  • Changes in the immune system
  • Changes in body fats (lipodystrophy)

Common 


 

  • Headache
  • Nausea
  • Diarrhea
  • Fatigue
  • Insomnia
  • Abdominal pain
  • Muscle or joint pain
  • Skin rash

Word of Advice

Follow prescribed dosage and instructions for Abakast L Tablets. Undergo genetic screening for hypersensitivity reactions and seek immediate medical attention if symptoms arise. Watch for lactic acidosis, monitor liver function, and adjust dosages for renal impairment. Be aware of immune reconstitution inflammatory syndrome, pancreatitis symptoms, and changes in body fat distribution. Consider potential drug interactions and consult a healthcare provider regarding use during pregnancy and breastfeeding. The use of this medication in both elderly individuals and children requires special consideration. Adherence and open communication ensure the safe use of this medication.


FAQs

Q 1. What is immune reconstitution inflammatory syndrome (IRIS), and how is it managed?

Immune reconstitution inflammatory syndrome can occur when starting antiretroviral therapy, including Abakast L Tablets, in individuals with advanced HIV infection. The sudden onset or worsening of inflammatory conditions characterizes it. The management of IRIS involves treating the underlying infections or inflammatory conditions and providing supportive care.

Q 2. Are there any specific tests or screenings required before starting Abakast L Tablets?

Before starting Abakast L Tablets, it is recommended to undergo genetic screening (HLA-B*5701) to identify individuals at higher risk of a hypersensitivity reaction. This screening helps in determining the suitability of abacavir use.

Q 3. Can Abakast L Tablets be used in patients with pre-existing liver or kidney disease?

Caution should be exercised when using Abakast L Tablets in individuals with pre-existing liver or kidney disease. Close monitoring of liver and kidney function may be necessary, and dose adjustments may be required based on the severity of the impairment.

Q 4. Can Abakast L Tablets be used in patients with hepatitis B or hepatitis C?

Abakast L Tablets can be used in individuals with HIV and hepatitis B or C coinfections. These medications have activity against the hepatitis B virus (HBV) and can help manage both infections simultaneously. However, it's important to consult with a healthcare provider who can assess the specific circumstances and determine the most appropriate treatment approach.

Q 5. Can Abakast L Tablets cause long-term complications?

While Abakast L Tablets are generally well-tolerated, long-term medication use can carry potential risks. Regular monitoring and follow-up with a healthcare provider are important to assess treatment response, monitor for side effects, and manage any potential long-term complications.

Q 6. Can I restart Abakast L Tablets if I previously had a hypersensitivity reaction?

Once a hypersensitivity reaction to Abakast L Tablets has occurred, the medication should not be restarted, as it can lead to a potentially life-threatening reaction. It is crucial to inform all healthcare providers about your hypersensitivity reaction history to prevent accidental re-initiation of abacavir in the future.


Fact Box of Abakast L Tablet

Molecule name: Abacavir and Lamivudine

Therapeutic class:  Antiviral

Pharmacological class: Nucleoside reverse transcriptase inhibitors (NRTIs)

Indications: HIV-1 Infection


References

  1. KD Tripathi, Essentials of Medical Pharmacology, Antiviral drugs, 7th edition, 2013, 807-808.
  2. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Antiretroviral agents and treatment of HIV infection, 12th edition, 2011, 1635-1636.
  3. Lupin Healthcare (UK) Limited, Electronic medicines compendium (EMC), [ Revised on April 2023] [ Accessed on 27th May 2023], https://www.medicines.org.uk/emc/landing/status=1
  4. ViiV Healthcare, US Food, and Drug Administration, [ Revised on May 2019] [ Accessed on 27th May June 2023], https://www.accessdata.fda.gov/drugsatfda_docs/pepfar/090519PI.pdf

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