AGGRIBLOC 5MG INJECTION

Introduction:

Aggribloc 5mg Injection is used to ease the blood flow to your heart and prevent chest pain and heart attacks. It is beneficial in patients with acute coronary syndrome, recurrent ischaemia and those at a high risk such as diabetes mellitus or high troponin concentration. It is recommended for patients whose heart vessels are dilated with stent, a procedure referred to as percutaneous coronary intervention (PCI).

Uses of Aggribloc 5mg Injection:

• Prevention of chest pain and heart attacks
• Concomitantly used with heparin for the treatment of the acute coronary syndrome
• To cover PCI or coronary artery bypass grafting.

How Aggribloc 5mg Injection works:

Glycoprotein IIb/IIIa receptors are present on the surface of platelets through which collagen, thrombin, ADP etc., finally induce platelet aggregation. Aggribloc 5mg Injection is a non-peptide Glycoprotein IIb/IIIa antagonist that inhibits protein binding to IIb/IIIa receptors of the glycoprotein present in the platelets. Thus, it blocks the final common pathway of platelet aggregation and inhibits platelet-rich clot formation.

Interaction with other drugs:

Inform your doctor about any medications you are taking or have taken before the treatment.

More Information:

Store at 25˚C and protect it from light. Do not freeze.

References:

1. James L. Zehnder, Drugs Used in Disorders of Coagulation, Lange’s Basic & Clinical Pharmacology, 14th Edition, 2018, 608-625.
2. KD Tripathi, Drugs Affecting Coagulation, Bleeding and Thrombosis, Essentials of Medical Pharmacology, 8th Edition, 2019, 659-681.
3. D.E. Newby, N.R. Grubb, A. Bradbury, Cardiovascular disease, Davidson’s Principles and Practice of Medicine, 22nd Edition, 2014, 525-641.
4. Beacon Pharmaceuticals Limited, Electronic Medicines Compendium (EMC), [Revised on Jan 2021] [Accessed on 5th Jun 2021], https://www.medicines.org.uk/emc/files/pil.3550.pdf
5. Biocon Limited, [Accessed on 5th Jun 2021], https://www.biocon.com/docs/prescribing_information/cardiology/tirozest_pi.pdf

How to use Aggribloc 5mg Injection: 

Aggribloc 5mg Injection is intended for administration as a continuous infusion. It should be prescribed by a qualified physician who is experienced in the management of heart attacks. Your physician will decide the appropriate dose depending on your condition and body weight.

Safety Advice:

Pregnancy:

Inform your physician before taking Aggribloc 5mg Injection if you are pregnant or think you might be pregnant.

Breastfeeding: 

It is unknown whether Aggribloc 5mg Injection is excreted in milk. Consult your physician for advice.

Liver:

Inform your physician before starting this treatment if you have liver diseases. Your physician will monitor your liver functions regularly.

Kidney:

Inform your physician before starting this treatment if you have kidney diseases. Your physician will monitor your kidney functions regularly.

Driving: 

Avoid driving or using machinery if you experience side effects.

Allergies: 

Inform your physician if you experience allergic reactions to Aggribloc 5mg Injection or its ingredients.

Others:

• Your physician will monitor your platelet count, haemoglobin and haematocrit values before treatment and within 6 hours of loading infusion. 
• Talk to your physician if you have a history of thrombocytopenia, stroke, severe hypertension, acute pericarditis or active internal bleeding.
• Inform your physician before starting this treatment if you have recently undergone major surgery or physical trauma.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Serious:

• Unusual bleeding
• Serious allergic reactions

Common:

• Sickness
• Headache
• Red bruises on the skin
• Blood in urine, stool, cough or at the site of injection
• Reduced levels of RBC, haemoglobin, haematocrit and platelets in the blood
• Fever