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Salt Composition : Netupitant,palonosetron
Manufacturer : GLENMARK PHARMACEUTICALS LTD
Origin of Medicine : India
1 Capsule(s) In A Strip
Introduction to Akynzeo Capsule
Akynzeo capsule contains the active ingredients netupitant and palonosetron. It is an antiemetic drug belonging to the class of 5-HT3 receptor antagonists. It is used to prevent and treat nausea, vomiting, or sickness caused by cancer treatments such as chemotherapy, radiotherapy, or after surgery. Nausea is characterised by stomach pain and the urge to vomit.
The common side effects that are likely to occur with this medicine are hives, swollen face, breathing trouble, and chest pain. Inform your healthcare provider if these side effects concern you or persist for longer than usual. It is given right away or later with anticancer medicines. It is usually given up to 24 hours while recovering from anesthesia after surgery.
Talk to your physician if you have a history of repeated constipation, blockage in the bowel, heart problems, or imbalance of certain minerals in your blood (such as magnesium and potassium). This medicine should not be used if you are allergic to this drug. Tell your physician about all the medications you have been taking recently, including herbal medicines and supplements, before taking the Akynzeo capsule.
Uses of Akynzeo Capsule
- Postoperative nausea and vomiting.
- Chemotherapy-induced nausea and vomiting.
Therapeutic Effects of Akynzeo Capsule
It is a type of serotonin receptor antagonist, which works by blocking the action of serotonin in the body that induces nausea and vomiting. The chemotherapeutic trigger zone(CTZ) contains the receptor serotonin, when this CTZ is stimulated, vomiting occurs. It prevents the signals from serotonin and helps to reduce the symptoms of nausea and vomiting.
Interaction of Akynzeo Capsule with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Akynzeo capsule and reduce effectiveness by causing undesirable side effects.
More Information about Akynzeo Capsule
- Store Akynzeo capsule in the original package at room temperature (25°C). Do not freeze.
- Keep it out of reach from children and pets.
- It is important to get the dose at the scheduled time. If you missed the schedule, contact your doctor and reschedule the dose.
How to consume Akynzeo Capsule
The medicine will be prescribed to you by a healthcare professional in a hospital setting. Akynzeo capsule is usually given about 30 minutes before you receive your anti-cancer medicine (chemotherapy) or right before anaesthesia for surgery. If you are taking an Akynzeo capsule, it should be swallowed whole with a glass of water, with or without food, as directed by your healthcare provider.
Safety Advices for Akynzeo Capsule
It is unknown whether Akynzeo capsule can be administered during pregnancy. Consult your doctor if you are pregnant or planning for pregnancy during the treatment.
It is not known if the Akynzeo capsule passes into your breast milk or if it will affect your baby or your breast milk. Please consult your doctor before breastfeeding.
It is not known whether Akynzeo capsule can be administered to patients with lung problems. Consult your doctor if you have any lung diseases before starting the treatment.
It is unknown whether Akynzeo capsule can be administered to patients with liver disorders. Inform your physician if you have any liver problems before starting treatment.
It is unknown whether consuming alcohol interacts with Akynzeo capsule. Please consult your doctor for more advice.
It is unsafe to drive vehicles or operate heavy machinery after taking Akynzeo capsule because it contains a small amount of alcohol which may cause dizziness and impair your concentration.
Side Effects of Akynzeo Capsule
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
- Swollen face
- Breathing trouble
- Chest pain
- Abdominal pain.
Word of Advice
Talk to your physician if you have a history of repeated constipation, blockage in the bowel, heart problems, or imbalance of certain minerals (such as potassium and magnesium) in your blood before taking Akynzeo capsule. Inform your doctor or nurse if you are taking any medicines that affect your heartbeat because they could cause a heartbeat problem when taken with this capsule.
Q 1. What are the possible side effects of Akynzeo capsule?
It can cause serious allergic reactions like hives, swollen face, breathing trouble, and chest pain. Some common side effects include headache and constipation.
Q 2. When should you take the Akynzeo capsule?
Akynzeo capsules can be taken with or without food with a glass full of water. The first dose of this drug is typically taken before the start of your surgery, chemotherapy, or radiation treatment.
Q 3. How does an Akynzeo capsule work?
Akynzeo capsule works by blocking the action of a chemical called serotonin, which is involved in causing nausea and vomiting.
Q 4. Who should not take an Akynzeo capsule?
Akynzeo capsule should not be taken by individuals who are allergic to it or its ingredients.
Q 5. What forms does the Akynzeo capsule come in?
Akynzeo capsule is available in the form of an oral tablet.
Fact Box of Akynzeo Capsule
Molecule name: Netupitant+Palonosetron
Therapeutic class: Antiemetics
1.Netupitant- Neurokinin 1 receptor antagonist
2.Palonosetron-5-HT3 receptor antagonist
1.Postoperative nausea and vomiting.
2.Chemotherapy induced nausea and vomiting.
- Accord Healthcare SLU, Electronic medicines compendium (emc), [Revised on Feb 2021] [ Accessed on 01st March 2023], https://www.medicines.org.uk/emc/files/pil.7235.pdf
- Fresenius kabi, US Food and Drug Administration, [Revised on Dec 2018] [Accessed on 01st March 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/208109s001lbl.pdf
- Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Treatment of disorders of bowel motility and water flux, 12th edition, 2011, 1341.
- KD Tripathi, Essentials of Medical Pharmacology, Antiemetic, prokinetic and digestant drugs, 7th edition, 2013, 669.
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