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Akynzeo Injection
Prescription Required
Salt Composition : Fosnetupitant,palonosetron
Manufacturer : GLENMARK PHARMACEUTICALS LTD
Origin of Medicine : India
1 Vial(s)
Introduction to Akynzeo Injection
Akynzeo Injection is an anti-emetic medication containing a fixed-dose combination of two active ingredients, such as fosnetupitant and palonosetron. Fosetupitant is a neurokinin-1 (NK-1) receptor antagonist, while palonosetron is a 5-HT3 receptor antagonist. This medication is used to prevent chemotherapy-induced nausea and vomiting (CINV). It is prescribed to help cancer patients to better tolerate their chemotherapy treatments by reducing the likelihood of these distressing side effects and is also used to control postoperative nausea and vomiting.
The common side effects that are likely to occur with this medicine are hives, swollen face, breathing trouble, and chest pain. Inform your healthcare provider if these side effects concern you or persist for longer than usual. If you have liver problems or renal impairment, discuss this with your physician. Dosing adjustments may be necessary in such cases. There is a potential risk of serotonin syndrome when Akynzeo Injection is combined with other serotonergic medications. Serotonin syndrome can cause symptoms such as agitation, hallucinations, rapid heartbeat, fever, muscle stiffness, and coordination problems. Inform your physician about all medications, including antidepressants and other serotonergic drugs, that you are taking.
The safety and efficacy of Akynzeo Injection in pediatric patients have not been established. It is primarily intended for use in adults. It is unsafe to administer this drug to pregnant women because it may cause harm to the baby. Please consult your doctor before taking this medicine. It is unclear whether this drug passes into breast milk for breastfeeding women, and consulting a doctor for guidance would be a better choice.
Uses of Akynzeo Injection
- Chemotherapy-induced nausea and vomiting.
- Postoperative nausea and vomiting.
Therapeutic Effects of Akynzeo Injection
Akynzeo Injection is a fixed-dose combination of two active ingredients, fosnetupitant and palonosetron. Fosnetupitant is a neurokinin-1 (NK-1) receptor antagonist, while palonosetron is a 5-HT3 receptor antagonist. Together, they work by blocking specific receptors in the brain and gut that trigger nausea and vomiting, providing more effective control of these side effects.
Interaction of Akynzeo Injection with other drugs
Inform your healthcare provider about all the medicines you take, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Akynzeo Injection and reduce effectiveness by causing undesirable side effects.
More Information about Akynzeo Injection
- Store Akynzeo Injection below (25°C).
- Do not freeze.
- Keep it out of reach from children and pets.
How to consume Akynzeo Injection
The medicine can be given only as an intravenous injection into a vein by your physician in a hospital setting. Akynzeo Injection is usually administered as a 30-minute infusion before you receive your anti-cancer medicine (chemotherapy) or right before anesthesia for surgery.
Safety Advices for Akynzeo Injection
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Pregnancy
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It is unsafe to use Akynzeo Injection in pregnant women because it may cause harm to the baby. Please consult your doctor before taking this medicine.Â
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Breast Feeding
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It is unknown whether Akynzeo Injection passes into breastmilk. Consult your doctor for more advice.
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Lungs
  It is unknown whether Akynzeo Injection can be used for patients with lung problems. Consult your doctor if you have any lung diseases before starting the treatment.
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Liver
  It is unknown whether Akynzeo Injection can be used for patients with liver disorders. Inform your physician if you have any liver problems before starting the treatment.Â
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Alcohol
 ÂIt is unknown whether consuming alcohol interacts with Akynzeo Injection. Please consult your doctor for more advice.
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Driving
  It is unknown whether Akynzeo Injection alters driving ability. However, if you experience side effects like tiredness or drowsiness, avoid driving and using machines.Â
Side Effects of Akynzeo Injection
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
 Serious
- Allergic reactions
- Hives
- Swollen face
- Breathing trouble
- Chest pain
 CommonÂ
- Headache
- Fatigue
- Dizziness
- Abdominal pain.
Word of Advice
Proper hydration can help reduce the risk of CINV. Drink plenty of fluids, and inform your physician if you have difficulty keeping fluids down. Try to maintain a balanced diet when possible. Eating small, frequent meals and snacks throughout the day can help prevent nausea and vomiting. Stress and anxiety can worsen nausea. Engage in relaxation techniques, such as deep breathing exercises or meditation, to help manage stress. Adequate rest and sleep are also important during the treatment with Akynzeo Injection.
FAQs
Q 1. What are the possible side effects of Akynzeo Injection?
Akynzeo Injection can cause serious allergic reactions like hives, swollen face, breathing trouble, and chest pain. Some common side effects include headache and constipation.
Q 2. How does an Akynzeo Injection work?
Akynzeo Injection works by blocking the action of a chemical called serotonin, which is involved in causing nausea and vomiting.
Q 3. How effective is Akynzeo Injection in preventing CINV?
Akynzeo Injection is considered effective in preventing chemotherapy-induced nausea and vomiting. It combines two different classes of antiemetic medications (NK-1 receptor antagonist and 5-HT3 receptor antagonist), which can provide more comprehensive control of nausea and vomiting associated with chemotherapy. The effectiveness may vary from person to person, but it is often prescribed to provide significant relief.
Q 4. Who should not take a Akynzeo Injection?
Akynzeo Injection should not be taken by individuals who are allergic to it or its ingredients.
Q 5. What forms does Akynzeo Injection come in?
Akynzeo Injection is available in the form of injection and tablet.
Fact Box of Akynzeo Injection
Molecule name: Fosnetupitant + Palonosetron | Therapeutic class: Antiemetics |
Pharmacological class: 1. Fosnetupitant- Neurokinin-1 (NK-1) receptor antagonist 2. Palonosetron- 5-HT3 receptor antagonists | Indications: 1. Chemotherapy-induced nausea and vomiting. 2. Postoperative nausea and vomiting. |
References
- Helsinn Birex Pharmaceuticals, US Food and Drug Administration, [Revised on April 2018] [Accessed on 13th Sept 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210493s000lbl.pdf
- Akynzeo (fosnetupitant/palonosetron) - Magellan Provider, [Accessed on 13th Sept 2023], https://specialtydrug.magellanprovider.com/media/91541/akynzeo-iv.pdf
- Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Treatment of bowel motility and water flux disorders, 12th edition, 2011, 1341.
- KD Tripathi, Essentials of Medical Pharmacology, Antiemetic, prokinetic and digestant drugs, 7th edition, 2013, 669.
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