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Alpostin 500mcg Injection
Salt Composition : Alprostadil
Manufacturer : SAMARTH LIFE SCIENCES PVT LTD
Origin of Medicine : India
1 Ampoule(s) Of 1ml
Introduction to Alpostin 500mcg Injection
Alpostin 500mcg Injection contains active components called Alprostadil. This medication is often used to treat ED in men with difficulty achieving or maintaining an erection. It may improve blood flow in patients with peripheral arterial disease (PAD), a condition in which blood flow to the extremities (usually the legs) is reduced. In newborns with certain heart conditions, such as PDA, it can open a blood vessel called the ductus arteriosus. It can also be used in diagnostic tests to assess blood flow in specific body areas, such as during penile Doppler ultrasound studies to evaluate erectile function.
Individuals who have a known allergy or hypersensitivity to Alpostin 500mcg Injection or any of its components should not use the medication. It should be avoided in men with penile implants or conditions that make penile injections unsafe, such as penile fibrosis, curvature, or priapism (prolonged erections). It should not be used in individuals with conditions predisposing them to priapism, such as sickle cell anemia, multiple myeloma, or leukemia. It should not be used in individuals who experience unexplained genital or pelvic pain, as it may indicate an underlying medical condition.
Individuals with bleeding disorders or those taking anticoagulant medications (blood thinners) should use Alpostin 500mcg Injection cautiously, as it may increase the risk of bleeding at the injection site. It should not be used concomitantly with alpha-blocker medications used to treat conditions like benign prostatic hyperplasia (BPH) and high blood pressure, as it can lead to severe low blood pressure. It should not be used in infants with congenital heart defects who have conditions that are worsened by increased blood flow to the lungs. It can be used in elderly patients, but caution may be required.
Uses of Alpostin 500mcg Injection
Alpostin 500mcg Injection is used for the following:
- Erectile dysfunction (ED)
- Peripheral arterial disease (PAD)
- Patent ductus arteriosus (PDA) in Infants
- Diagnostic testing
Therapeutic Effects of Alpostin 500mcg Injection
Alpostin 500mcg Injection binds to specific receptors on smooth muscle cells in blood vessels and tissues. When it binds to these receptors, it triggers biochemical events that lead to vasodilation. It relaxes the smooth muscles in blood vessel walls, particularly in the penis, when used for erectile dysfunction. It involves promoting the relaxation of smooth muscle cells and improving blood flow to specific body areas, depending on its intended use.
Interaction of Alpostin 500mcg Injection with other drugs
Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Alpostin 500mcg Injection, reducing effectiveness by causing undesirable side effects.
More Information about Alpostin 500mcg Injection
- Store at room temperature below 20 to 25°C
- Keep away from moisture, heat, and light.
- It should not be frozen.
- Keep away from children and pets.
How to consume Alpostin 500mcg Injection
Alpostin 500mcg Injection can be administered via various routes, depending on the medical condition. For erectile dysfunction (ED), it can be injected directly into the penis (intracavernosal injection), applied topically to the penile tip (urethral application), or used as a urethral suppository.
Safety Advices for Alpostin 500mcg Injection
If you are pregnant or trying to become pregnant, it is important to talk to your doctor before taking Alpostin 500mcg Injection.
There is limited research on the safety of Alpostin 500mcg Injection in breastfeeding women. It is important to talk to your doctor before taking this medication.
If you have lung disease, talking to your doctor before taking Alpostin 500mcg injection is important.
Alpostin 500mcg Injection is metabolized in the liver, so individuals with severe liver disease may require dose adjustments. Patients with liver problems should discuss their condition with their healthcare provider before using it.
It is unsafe to drink alcohol while taking Alpostin 500mcg Injection. Excessive alcohol consumption can increase the risk of certain side effects.
Alpostin 500mcg Injection can cause dizziness or fainting, especially if low blood pressure occurs. If you experience any side effects, consult your healthcare provider before taking it while driving.
Side Effects of Alpostin 500mcg Injection
Alpostin 500mcg Injection causes some side effects like all medications, although not everyone will experience them.
- Penile fibrosis
- Allergic reactions
- Low blood pressure
- Cardiovascular effects
- Pain or discomfort
- Penile burning or tingling
- Urethral irritation
- Flu-like symptoms
Word of Advice
Use Alpostin 500mcg Injection under medical supervision to determine the right dose and method. Watch for priapism (prolonged erection) and seek immediate help if it occurs. Inform your healthcare provider of any underlying medical conditions, such as bleeding disorders, heart conditions, or liver disease, as dose adjustments or special precautions may be necessary. Be cautious with penile abnormalities or predisposition to priapism. Monitor the use of this medication in infants and consider benefits versus risks. Avoid it if you are allergic to it or its components. Use alcohol with caution, and be aware of medication interactions. Assess how this medication affects you before driving or operating machinery. Discuss its use during pregnancy and breastfeeding with your healthcare provider. Follow storage instructions for safe and effective use.
Q 1. What is the risk of priapism with Alpostin 500mcg Injection?
Priapism, a prolonged and painful erection, is a potential side effect of Alpostin 500mcg Injection. It is a serious condition and requires immediate medical attention.
Q 2. Can women use Alpostin 500mcg Injection?
Alpostin 500mcg Injection is primarily used in men, but some applications exist for women, such as treating sexual arousal disorders or facilitating certain medical procedures. Its use in women should be discussed with a healthcare provider.
Q 3. Can I use Alpostin 500mcg Injection for recreational purposes or to enhance sexual performance?
Alpostin 500mcg Injection is a prescription medication and should only be used under medical supervision for legitimate medical reasons. Its recreational use is not recommended and can be dangerous.
Q 4. How long can I safely use Alpostin 500mcg Injection for ED?
Your healthcare provider should determine the duration of the Alpostin 500mcg Injection for ED. Long-term use should be monitored for potential side effects.
Q 5. Can I adjust the dosage of Alpostin 500mcg Injection on my own?
Do not adjust the dosage of Alpostin 500mcg Injection without consulting your healthcare provider. They will determine the appropriate dosage based on your condition.
Q 6. What are the common side effects of Alpostin 500mcg Injection?
Common side effects of Alpostin 500mcg Injection may include pain or discomfort at the injection site (for intracavernosal injections), penile burning or tingling (for topical or urethral forms), headache, flushing, and flu-like symptoms.
Fact Box of Alpostin 500mcg Injection
Molecule name: Alprostadil
Therapeutic class: Vasodilator
Pharmacological class: Prostaglandin E1 (PGE1) Analog
1. Erectile dysfunction (ED)
2. Peripheral arterial disease (PAD)
3. Patent ductus arteriosus (PDA) in Infants
4. Diagnostic testing
- Pfizer Limited, Electronic Medicines Compendium (EMC), [Revised on Apr 2021] [Accessed on 3rd Oct 2023], https://www.medicines.org.uk/emc/files/pil.1092.pdf
- John Hwa, Kathleen Martin, The Eicosanoids: Prostaglandins, Thromboxanes, Leukotrienes, & Related Compounds, Lange’s Basic & Clinical Pharmacology, 14th Edition, 2018, 321-338.
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