Quick Summary
Amigraf 0.5mg Capsule
Last updated on 31 Mar 2026 | 09:31 AM (IST)
₹184
MRP: ₹215
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10 CAPSULE(s) IN A STRIP
14% OFF
₹184
MRP: ₹215.00
Inclusive of all taxes
14% Off
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Introduction
Amigraf 0.5mg Capsule contains Tacrolimus as its active ingredient and is manufactured by a trusted Amigraf 0.5mg manufacturer. It is an immunosuppressant used to prevent organ rejection, especially after kidney and liver transplants. The Amigraf 0.5 mg composition helps control the immune system, making it essential for transplant patients.
Doctors prescribe the Amigraf 0.5mg dosage carefully, with specific adjustments for the Amigraf 0.5mg dosage for kidney transplant depending on blood levels. Like all medicines, it has benefits and risks, so patients should be aware of Amigraf 0.5mg uses and side effects, including nausea, infections, and kidney issues. Alternatives are available as Amigraf 0.5mg substitutes, but switching should be done only under medical advice. The Amigraf 0.5mg price may vary by location and pharmacy, making it important to check availability before purchase.
Uses
Amigraf 0.5mg uses
- Prevent organ transplant rejections.
How Amigraf 0.5mg Capsule works
Amigraf 0.5mg Capsule provides immunosuppression by inhibiting T-lymphocyte activation and proliferation and T-helper-cell-dependent B-cell response. It works by attaching to a protein called FKBP-12 and forms a complex called tacrolimus-FKBP, which inhibits the action of calcineurin phosphatase. This, in turn, inhibits the formation of T cells and suppresses the immune response.
Interaction of Amigraf 0.5mg Capsule with other drugs
Inform your healthcare provider about all the medicines that you take, including prescription medications, over-the-counter medications, vaccinations, nutritional and vitamin supplements, and herbal products. Certain medications may interact with the effects of Amigraf 0.5mg Capsule and reduce its effectiveness by causing undesirable side effects. Avoid grapefruit or grapefruit juice while taking this medicine.
Storage conditions
- Store Amigraf 0.5mg Capsule at (25°C)
- keep the capsule away from the reach of children and pets.
- If you miss a dosage, take it as soon as you remember. If it is almost time for the next dose, skip the missing dose.
- Do not take a double dose to compensate for a missed dose.
How to take Amigraf 0.5mg Capsule
Your doctor will decide the dose and duration of the treatment based on your disease condition, severity, and other factors. Always take Amigraf 0.5mg Capsule as prescribed by your doctor. Do not open, break, crush, or chew the capsules. Swallow the capsule whole with a glass of water. Take these capsules on an empty stomach or at least 1 hour before or 2 to 3 hours after the meal.
Safety Advice for Amigraf 0.5mg Capsule
Breast Feeding
Do not consume Amigraf 0.5mg Capsule if you are breastfeeding because this medicine is excreted into breast milk and may cause harmful effects on the body.
Alcohol
It is unsafe to consume alcohol when taking Amigraf 0.5mg Capsule because it may cause excessive drowsiness or liver problems.
Liver
Amigraf 0.5mg Capsule should be cautiously administered in patients with severe liver diseases. Dose adjustments are necessary for severe liver failure. Inform your doctor if you have liver problems before initiating the therapy.
Lungs
It is unknown whether Amigraf 0.5mg Capsule can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.
Driving
Driving vehicles or operating machinery while taking Amigraf 0.5mg Capsule is unsafe because it may cause drowsiness and vision problems.
Pregnancy
Based on animal studies, Amigraf 0.5mg Capsule can cause harmful effects on the baby. Inform your physician if you are pregnant, suspecting pregnancy or planning to get pregnant before initiating the treatment.
Side Effects
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Amigraf 0.5mg side effects are
Common
- Swelling in the arm or leg
- Hair loss
- Itchy skin
- Constipation, diarrhea
- Nausea, vomiting
- Anemia
- Headache
- Cough
Serious
- Increased or decreased heartbeats
- GI bleeding
- Liver Injury
- Seizure
- Acute kidney failure
- Lung infection or respiratory problems
Expert Tips
-
Do not eat grapefruit or drink grapefruit juice while taking Amigraf 0.5mg Capsule.
-
Avoid drinking alcohol during the treatment.
-
This medicine may interfere with vaccines; consult your healthcare professional before getting a flu shot or other vaccinations.
-
Amigraf 0.5mg Capsule is a long-term treatment to prevent rejection of transplanted organs.
-
Do not stop taking this medicine without your doctor’s advice.
-
Your doctor may recommend certain tests to monitor both effectiveness and side effects of the therapy.
-
Keep all medical appointments regularly as advised by your doctor.
FAQs about Amigraf 0.5mg Capsule
Q1.
What if I missed a dose of Amigraf 0.5mg Capsule?
Try to take it as soon as possible, you remember. If it is time for the next dose, skip the missed dose and follow the regular schedule. Do not double the dose to make up for the forgotten dose.
Q2.
What should you not use with Amigraf 0.5mg Capsule?
Avoid taking mycophenolic acid-containing products, nelfinavir, sirolimus, cyclosporine, antibiotics, and antiviral medications. Inform your healthcare provider about any prescription medicines, over-the-counter medications, or vitamin or herbal supplements you have taken before the treatment.
Q3.
When can I stop taking Amigraf 0.5mg Capsule after my transplant?
The duration of Amigraf 0.5mg Capsule treatment after a transplant can vary depending on various factors, including the type of organ transplant and the individual's response to the medication. In most cases, Amigraf 0.5mg Capsule is taken long-term to prevent organ rejection, but the healthcare professional will determine the specific duration.
Q4.
Can Amigraf 0.5mg Capsule increase the risk of infections?
Yes, Amigraf 0.5mg Capsule can suppress the immune system, which may increase the risk of infections. It is important to take precautions to minimize the risk of infections, such as practicing good hygiene, avoiding close contact with individuals who are sick, and getting recommended vaccinations.
Q5.
Can Amigraf 0.5mg Capsule affect kidney function?
Amigraf 0.5mg Capsule must be cautiously administered in patients with kidney diseases because it can potentially affect kidney function. Regular monitoring of kidney function through blood tests is typically done to detect any changes or potential complications. Inform your physician if you have kidney problems before initiating the therapy.
Q6.
Should I follow any dietary restrictions while taking Amigraf 0.5mg Capsule?
Amigraf 0.5mg Capsule can interact with certain foods and beverages, particularly grapefruit and grapefruit juice, which may increase the levels of this medicine in the blood. Discussing dietary restrictions and potential interactions with your healthcare provider is important.
Fact Box of Amigraf 0.5mg Capsule
|
Molecule name |
Tacrolimus |
|
Therapeutic class |
Immunosuppressant |
|
Pharmacological class |
Calcineurin inhibitors |
|
Indications |
Prevent organ transplant rejections |
References
- Prograf 0.5mg Hard Capsules - Summary of Product Characteristics (SmPC) - (emc). www.medicines.org.uk. Published December 2022. Accessed May 25, 2023. https://www.medicines.org.uk/emc/product/6720/smpc
- Highlights Of Prescribing Information, Prograf ® (Tacrolimus) Capsules PROGRAF ® (Tacrolimus) Injection, (for Intravenous Use).; Revised 2012. Accessed May 25, 2023. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/050709s031lbl.pdf
- Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Immunosuppressants, tolerogens, and immunostimulants, 12th edition, 2011, 1008.
- KD Tripathi, Essentials of Medical Pharmacology, Immunosuppressant drugs, 7th edition, 2013, 881.
Disclaimer
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Author Details
Written By
Dr. Karpagam A.
Pharm D
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 31 Mar 2026 | 09:31 AM (IST)
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