ARGANAT 250MG INJECTION

Introduction:

Arganat 250mg Injection is an anticoagulant medication containing the active constituent Argatroban. It is used to prevent the clot formation of blood. It is used mainly in heparin-induced thrombocytopenia (low number of platelets in the body due to the usage of heparin medicine). Blood clots are potential reasons for heart attacks (blockage of blood supply to heart muscles due to the formation of clots in the blood vessels), stroke, breathing problems, and the problematic blood supply to the limbs.

Arganat 250mg Injection should not be administered in patients having uncontrolled bleeding or hypersensitive individuals. Inform the doctor if you have liver disorders or have recently taken any anticoagulant injections. This medication is not recommended for adolescents or children as the safety of the medicine has not been established clearly. 

Uses of Arganat 250mg Injection:

• Heparin-induced thrombocytopenia

How Arganat 250mg Injection works:

It gets attached to the protein called thrombin, which is involved in clot formation and prevents blood clot formation.

Interactions with other drugs:

Inform your doctor about any medications you are taking or have taken before the treatment.

More information:

Store the vials in cartons at room temperature 25° C protected from light. Do not freeze.

References:

1. KD Tripathi, Essentials of Medical Pharmacology, Drugs affecting Coagulation, bleeding and Thrombosis, 7th edition, 2013, 620.
2. GlaxoSmithKline, US Food and Drug Administration, [ Accessed on 3rd April 2021], https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/020883s014lbl.pdf
3. Mitsubishi Tanabe Pharma Europe Ltd, Electronic medicines compendium (emc), [ Revised on Feb 2018] [ Accessed on 3rd April 2021], https://www.medicines.org.uk/emc/product/2012/pil

How to use Arganat 250mg Injection:

The Arganat 250mg Injection will be administered intravenously by your health care professional. 

Safety advice:

Pregnancy: 

Inform your doctor if you are pregnant or planning to get pregnant before taking the Arganat 250mg Injection

Breastfeeding:

The use of Arganat 250mg Injection should be avoided during the breastfeeding. Consult your doctor for risk and benefits.

Liver: 

Inform your doctor if you have severely impaired liver function 

Driving: 

The Arganat 250mg Injection may cause dizziness; consult your doctor before engaging in driving while receiving the medication.

Others:

• Inform your doctor if you have uncontrolled bleeding

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.

Serious:

• Bleeding or bruising
• Anemia
• Urinary tract infection
• Speech disorder, vision problems
• muscle disorder
• Stroke
• Abnormal liver function, jaundice (yellowing of skin and eyes)
• Shock
• Kidney failure
• Heart attack

Common:

• Lack of appetite
• Fainting, dizziness
• Headache, confusion
• Low sugar levels in the blood
• Abnormal heart rhythm, fast heartbeat
• High/ low blood pressure
• Breathing difficulties
• Blood in hiccup, vomit or stools, black stools
• Dilated pupils, dry mouth
• Difficulty swallowing
• Diarrhea
• Constipation
• Fever, tiredness
• Increased wound drainage
• Swelling of legs
• Increased sweating
• Hair loss
• Rash, itching
• Injection site reactions