Aromasin 25mg tablet is an anticancer drug with the active ingredient Exemestane. It belongs to the medication class known as aromatase inhibitors. In postmenopausal women, it is used to treat hormone-dependent early breast cancer after completing 2-3 years of treatment with Tamoxifen. In addition, it also treats hormone-dependent advanced breast cancer.  Cancer is a disorder in which cells multiply in an uncontrolled and abnormal manner. Do not take this medicine if you are allergic to Exemestane or any of the other ingredients of this medicine if you have not been through the menopause stage, or if you think you are pregnant or breastfeeding. 

Aromasin 25mg tablet is not recommended for adolescents and children under the age of 18. Inform your doctor before starting the treatment if you have problems with your liver or kidney or if you have a history of bone condition, as this medicine can make you lose mineral content and decrease its strength. Inform your doctor if you take any other medicine while under this treatment. Regular checking will be conducted to monitor the vitamin D level, if your level is below normal you will be given vitamin D. You need to tell your doctor about all the medications you are taking recently before taking this medicine. Use effective birth control during the treatment with this medicine. 

• Breast cancer

Exemestane inhibits the enzyme aromatase, which is responsible for the conversion of androgens (male hormones) to estrogen (female hormones). By inhibiting aromatase, Exemestane reduces the levels of estrogen in the body. This can stop or reduce the growth of different hormone-sensitive breast cancer cells, which depend on estrogen. 

Inform your healthcare provider about all your medicines, including prescribed medications, over-the-counter medicines, nutritional or vitamin supplements, and herbal products. Certain medications may interact such as Rifampicin, Carbamazepine, or phenytoin, and St. John Wort interacts with Aromasin 25mg and reduce effectiveness by causing undesirable side effects. 

• Store the tablets below 30°C.
• Keep the tablets away from light and moisture.
• Keep the tablets out of the reach of children and animals.
• This medicine does not require any special storage conditions.

Swallow the tablet whole with water. The usual recommended dose is one tablet daily. Avoid chewing, breaking, or crushing it. Your physician will choose the dosage and administration frequency based on the medical condition because it differs for each person.

Side effects are unwanted symptoms produced by medication. Even though all medications cause side effects, not everyone gets them. 

Serious

• Lowered white blood cell (leukopenia)
• Reduction of platelets in the blood
• Allergic reaction
• Difficulty in breathing 

Common

• Numbness and hand pain (Carpal tunnel syndrome)
• Depression
• High levels of liver enzymes
• Diarrhea, Nausea
• Depression
• Joint and back pain
• Fatigue
• Abdomen pain
• Swelling in hands and feets
• Muscle pain
• Tingling, pain, coldness, weakness in parts of the hand.

It is advised to inform your doctor if you have a history of liver or kidney diseases. Aromasin 25mg Tablet reduces levels of the estrogen hormone. You can have weaker bones that are more likely to break. Do not get pregnant or breastfeed. Use effective contraception throughout the treatment. 

1. Zentiva Pharma UK limited, Electronic medicines compendium (EMC), [Revised on July 2022] [Accessed on 21st April 2023], Exemestane 25mg film-coated tablets - Patient Information Leaflet (PIL) - (emc) (medicines.org.uk)
2. Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.