ATGAM 250MG INJECTION
ANTITHYMOCYTE IMMUNOGLOBULINS
Manufacturer : PFIZER LTDOrigin of Medicine : United States of AmericaIntroduction:
Atgam 250mg Injection is a purified and sterile form of gamma globulin. It is isolated from the hyperimmune plasma of horses immunized with human white blood cell components. It is used after kidney transplantation along with other therapies to treat as well as delay organ rejection. After solid organ transplantation, the body generates an aggressive immune response because it recognizes the transplanted organ's antigens as a foreign antigen. Thus, treatment with immunosuppressive agents is necessary after an organ transplant to prevent organ rejection.
Uses of Atgam 250mg Injection:
- Treatment and delay of acute rejection in patients who have undergone kidney transplantation.
- Adjunct therapy with other immunosuppressant drugs to produce immunosuppression.
- Reduction of T-cell function in bone marrow transplantation and aplastic anaemia.
How Atgam 250mg Injection Works:
Atgam 250mg Injection works by inhibiting the activation of T-cells and inducing its clearance from circulation. It selectively reduces the number of thymus-dependent lymphocytes participating in circulation. By suppressing and depleting T-cells, this Injection proves to be effective in treating immunity-related graft rejection.
Interaction with other drugs:
Inform your doctor about any medications you are taking or have taken before the treatment.
More Information:
Store in the original packaging in a refrigerator. Do not freeze.
References:
- S.E. Marshall, Immunological Factors in disease, Davidson’s Principles and Practice of Medicine, 22nd Edition, 2014, 71-96.
- Pfizer, [Revised on July 2018] [Accessed on 7th May 2021], https://www.pfizer.ca/…
- Genzyme Corporation, US Food and Drug Administration, [Revised on Apr 2017] [Accessed on 7th May 2021], https://www.fda.gov/media/74641/download
How to use Atgam 250mg Injection:
This injection should be administered only by physicians skilled and experienced in immunosuppressant therapy in transplantation.
Safety Advice:
Pregnancy:
Inform your physician before taking Atgam 250mg Injection if you are pregnant or think you might be pregnant.
Breastfeeding:
Atgam 250mg Injection passes through breast milk. Consult your physician for advice before breastfeeding.
Liver:
Inform your physician before taking Atgam 250mg Injection if you have liver problems.
Kidney:
Inform your physician before taking Atgam 250mg Injection if you have kidney problems.
Driving:
Practice caution while driving or doing things that require concentration if you experience any side effects.
Allergies:
Inform your physician immediately if you experience allergic reactions to Atgam 250mg Injection or its ingredients
Others:
- Inform your physician if you have aplastic anaemia or other blood abnormalities.
- Inform your physician if you have a history of infections.
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious:
- Anaphylactic reaction
- Infections
- Increased risk of cancer
- High potassium and low platelet and WBC count in blood
Common:
- Urinary tract infection
- Stomach pain
- High BP
- Nausea
- Fever, headache and chills
- Anxiety
- Skin reactions

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