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Benzz 100mg Injection
Salt Composition : Bendamustine
Manufacturer : INTAS PHARMACEUTICALS LTD
Origin of Medicine : India
Introduction to Benzz 100mg Injection
Benzz 100mg Injection is an antineoplastic drug belonging to the class of alkylating agents, containing the active ingredient Bendamustine. It is used to prevent and treat chronic lymphocytic leukaemia (cancer of blood and bone marrow), non-Hodgkin’s lymphomas (cancer that forms in the lymph system, part of the immune system), and multiple myelomas (cancer of plasma cells, type of white blood cell).
The common side effects that are likely to occur with this medicine are headache, insomnia, fatigue, loss of appetite and rashes. Some serious side effects also include bone marrow suppression, tumor lysis syndrome, and Hepatotoxicity. Inform your healthcare provider if these side effects concern you or persist for longer than usual. It is often combined with rituximab, an immunotherapy drug, to treat various subtypes of non-Hodgkin's lymphoma, including follicular lymphoma, and mantle cell lymphoma. There may be an increased risk of certain types of skin cancer (non-melanoma skin cancer) with the use of this medicine. Consult your doctor immediately for more advice.
Treatment should not be started if your white blood cells (leukocytes) have fallen to counts below determined levels. Your doctor will determine these values at regular intervals. This medicine should not be used if you are allergic to this drug. If you are a man wanting to father a child, you should discuss the treatment with your physician, as taking injections may reduce sperm production in men. This drug is typically given as an intravenous infusion over a period of 30-60 minutes. It is usually administered once every three to four weeks. Tell your physician about all the medications you have been taking recently, including herbal medicines and supplements, before taking Benzz 100mg Injection.
Uses of Benzz 100mg Injection
- Chronic lymphocytic leukaemia.
- Non-Hodgkin’s lymphomas
- Multiple myeloma
Therapeutic Effects of Benzz 100mg Injection
It is a type of alkylating agent, which works by causing DNA damage and disrupting the cell cycle, leading to cancer cell death. It forms covalent bonds with DNA, inhibits DNA repair enzymes, and blocks cell cycle progression. Benzz 100mg Injection is used as a cytotoxic drug that kills cancer cells by inhibiting their DNA and cell cycle.
Interaction of Benzz 100mg Injection with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Benzz 100mg Injection and reduce effectiveness by causing undesirable side effects.
More Information about Benzz 100mg Injection
- Store Benzz 100mg Injection in the refrigerator (2°-8°C). Do not freeze.
- Keep it out of reach from children and pets.
- It is important to get the dose at the scheduled time. If you missed the schedule, contact your doctor and reschedule the dose.
How to consume Benzz 100mg Injection
The medicine will be administered to you by a healthcare professional in a hospital setting. This injection will be given intravenously into a vein in your arm or hand. Do not self-administer this medicine. The dose of the injection will be decided by your doctor based on your disease condition and other factors. Benzz 100mg Injection is usually given about 30 minutes before you receive your anti-cancer medicine (chemotherapy) or right before anaesthesia for surgery. During the infusion, you will be monitored for any side effects or reactions to the medication. The infusion usually takes several hours to complete, and you may need to receive multiple infusions over the course of several weeks.
Safety Advices for Benzz 100mg Injection
Benzz 100mg Injection is not recommended for pregnant women as it may cause fetal harm. Consult your doctor if you are pregnant or planning for pregnancy during the treatment.
It is not known if Benzz 100mg Injection passes into your breast milk or if it will affect your baby. Please consult your doctor before breastfeeding.
It is not known whether Benzz 100mg Injection can be administered to patients with lung problems. Consult your doctor if you have any lung diseases before starting the treatment.
Inform your doctor if you have any liver problems before taking Benzz 100mg Injection. Regular monitoring of liver function tests is recommended.
Consuming alcohol may affect the effectiveness of Benzz 100mg Injection. Stop consuming alcohol if you are taking this medicine.
It is unsafe to drive vehicles or operate heavy machinery after taking Benzz 100mg Injection, it may cause dizziness and impair your concentration.
Side Effects of Benzz 100mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
- Severe allergic reactions
- Bone marrow suppression
- Abnormal liver function
- Tumor lysis syndrome
- Infection, fever
- Low blood cell count
- Headache, dizziness
- Nausea, vomiting
- Increased blood level of creatinine and urea (chemical waste products)
- Mucosal inflammation, sore mouth
- Insomnia, fatigue
- Hair loss, itching, rash
- Diarrhea, constipation
- Missed periods
- Dehydration, loss of appetite
- Low or high blood pressure
Word of Advice
Benzz 100mg Injection can cause harm to a developing fetus or nursing baby, so it is important to discuss contraception options and the need to avoid breastfeeding during treatment. This drug causes fatigue, so encourage the patient to take enough rest and self-care during treatment. This injection increases the risk of bleeding and bruising, so it is important to be careful when using sharp objects or participating in activities that may result in injury.
Q 1. What is Benzz 100mg Injection used for?
Benzz 100mg Injection is a chemotherapy drug used to treat various types of cancers, including non-Hodgkin's lymphoma, chronic lymphocytic leukaemia, and multiple myeloma.
Q 2. How will I receive Benzz 100mg Injection?
Benzz 100mg Injection is administered into a vein as a short-term infusion over 30 – 60 minutes.
Q 3. How does Benzz 100mg Injection work to treat cancer?
Benzz 100mg Injection works by damaging the DNA in cancer cells, preventing them from multiplying and spreading.
Q 4. Can Benzz 100mg Injection be used in combination with other drugs?
Yes, Benzz 100mg Injection is often used in combination with other chemotherapy drugs to improve treatment outcomes.
Q 5. Whether Benzz 100mg Injection is safe to use during pregnancy?
Benzz 100mg Injection is not recommended during pregnancy and it is unsafe because it may harm a developing fetus. Women who are pregnant or planning to become pregnant should discuss their treatment options with their doctor immediately.
Q 6. Who should not take Benzz 100mg Injection?
Benzz 100mg Injection should not be taken by individuals who are allergic to it or its ingredients.
Fact Box of Benzz 100mg Injection
Molecule name: Bendamustine
Therapeutic class: Antineoplastics
Pharmacological class: Alkylating agents
1. Chronic lymphocytic leukaemia.
2. Non-Hodgkin’s lymphomas
3. Multiple myeloma
- Zentiva Pharma UK Limited, Electronic medicines compendium (emc), [ Revised on April 2019] [ Accessed on 14th March 2023], https://www.medicines.org.uk/emc/files/pil.7302.pdf
- Teva Pharmaceuticals USA, Inc, US Food and Drug Administration, [ Revised on Feb 2017] [ Accessed on 14th March 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208194s005lbl.pdf
- Bendamustine 25mg how to store Bendamustine Powder, [Accessed on 14th March 2023], https://cdn.accord-healthcare.com/ie/public/pil/pil_for_website_bendamustine.pdf
- Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Chemotherapy of neoplastic diseases, 12th edition, 2011, 1684.
- Bertram.G.Katzung, Basic and Clinical Pharmacology, Cancer Chemotherapy, 14th edition, 2017, 956.
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