BIODRONATE 30MG INJECTION

Introduction:

Biodronate 30mg Injection consists of the active substance Pamidronate. It is an anti-cancer drug that belongs to the class of medicines called second-generation Bisphosphonates. Biodronate 30mg Injection helps manage low calcium levels in the blood and prevents bone loss in patients suffering from cancer in the breast and bone marrow. It is also indicated for preventing skeletal related events like bone pain, compression of spinal cord in patients with known history of bone cancer. 

Uses of Biodronate 30mg Injection:

Biodronate 30mg Injection is used to treat the following conditions:

• Bone metastases caused by breast or bone marrow cancer.
• Paget’s disease
• High calcium levels in the blood caused by tumors

How Biodronate 30mg Injection Works:

Biodronate 30mg Injection works by forming a strong bond with calcium phosphate crystals of the bone and slows down the rate of formation and dissolution of the bone components. This Injection is beneficial for preventing bone resorption and inhibiting osteoclast activity. Reduced bone resorption lowers the risk of fractures.

Interaction with other drugs:

Inform your doctor about any medications you are taking or have taken before the treatment.

More Information:

Biodronate 30mg Injection can be stored for 24 hours in temperature 2-8°C. Do not freeze. Store the vials in the outer carton to protect it from light. 

References:

1. Hospira UK Ltd, Electronic Medicines Compendium (EMC) [Revised on Feb 2021] [Accessed on 1st Mar 2022], https://www.medicines.org.uk/emc/files/pil.6455.pdf
2. Pfizer Canada ULC, [Revised on 11th Dec 2018] [Accessed on 9th Apr 2021], https://www.pfizer.ca/sites/default/files/201812/Pamidronate_PM_E_220092_11Dec2018.pdf
3. Shannon Palmer et al., Safety of Intravenous Bisphosphonates for the Treatment of Hypercalcemia in Patients With Preexisting Renal Dysfunction, Annals of Pharmacotherapy, 27th Aug 2020, Page 303-310, [Accessed on 9th Apr 2021], https://journals.sagepub.com/doi/pdf/10.1177/1060028020953501

How to use Biodronate 30mg Injection: 

Your physician will calculate the accurate dose for you before injecting this medicine. Do not use it if the solution has particles in it.

Safety Advice: 

Pregnancy:

Biodronate 30mg Injection is recommended only when there are no other alternatives available. Consult your physician before taking Biodronate 30mg Injection if you are pregnant or think you might be pregnant. 

Breastfeeding: 

Discuss with your physician before starting this treatment if you are breastfeeding or planning to breastfeed your baby.

Liver: 

Inform your physician before beginning Biodronate 30mg Injection therapy if you have liver disease.

Kidney:

Inform your physician before treatment with Biodronate 30mg Injection if you have kidney disease.

Driving:

Do not drive vehicles or use machines if you experience symptoms of dizziness or confusion.

Others:

• A dental examination is recommended before initiating treatment with Biodronate 30mg Injection if you have or ever had pain, swelling or numbness of the jaw or loose teeth.
• Inform your physician before initiating treatment with Biodronate 30mg Injection if you have thyroid problems, heart problems, anemia, calcium or vitamin D deficiency or ear infections.  
• Female patients of reproductive potential should use a reliable method of contraception while on treatment with Biodronate 30mg Injection.
• Inform your physician if you have hypersensitivity to bisphosphonates or its ingredients.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Serious:

• Severe allergic reactions – skin reactions, swelling of hands, feet, ankles, face, lips, mouth or throat.
• Dizziness
• Osteonecrosis of the jaw
• Kidney damage

Common:

• Pain in the joints, muscles and bones
• Sickness
• Headache
• Pain, swelling and redness at the area of injection
• Conjunctivitis
• Anaemia
• Low levels of white blood cells and platelets
• Low levels of potassium and magnesium
• High values in function tests
• Numbness and tingling sensation
• Sleeplessness
• Skin rashes
• Loss of appetite
• Constipation
• High BP