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Methotrexate overdose and toxicity
Prevent the harmful effects of methotrexate or similar medications
Colorectal cancer
Anemia

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Biovorin 50mg Injection counteracts the therapeutic effects of folic acid antagonists such as methotrexate and similar medications by inhibiting the dihydrofolate reductase enzyme. It treats anemia by supplying the folic acid needed for red blood cell formation. It treats colorectal cancer by enhancing the therapeutic effects of another anticancer medication called 5-fluorouracil.

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Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. Certain medications may interact with the effects of Biovorin 50mg Injection and reduce its effectiveness by causing undesirable side effects. Especially inform your physician if you are taking medications for seizures.

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Store Biovorin 50mg Injection in a refrigerator at 2° to 8°C
Keep the injection away from the reach of children and pets.
If you forgot your dosing schedule, inform your healthcare professional immediately and reschedule the dosing

"}},{"id":"5b99fe01-3246-4472-a0e1-8b6c13810392","type":"PARA","position":6,"content_placement":1,"data":{"heading":"How to consume Biovorin 50mg Injection","text":"

A trained physician or nurse in cancer chemotherapy will administer the drug to you. Your doctor will decide the dose and duration of the treatment based on your disease condition, severity, and other factors. The medicine is administered either intravenously (into your vein) or intramuscularly (into your muscle) based on your disease condition.

"}},{"id":"187e906b-f09c-48e5-a76e-20e2c7471da2","type":"SAFETY_ADVICE","position":7,"content_placement":2,"data":{"heading":"Safety Advice for Biovorin 50mg Injection","safety_list":[{"id":"cd1d04e9-fc5b-40d5-9127-6933496cd4d4","advice":"Breast Feeding","tag":"Consult your doctor","description":"

Limited information is available on Biovorin 50mg Injection safety during breastfeeding. Inform your physician if you are planning to breastfeed.

","imageUrl":"https://assets.mrmed.in/others/file-1674132409667-45039420-Breatfeeding.jpg"},{"id":"85110ad4-779a-49af-8675-7cc952c303d0","advice":"Alcohol","tag":"Consult your doctor","description":"

It is unknown whether it is safe to consume alcohol when taking Biovorin 50mg Injection. Consult your doctor for more advice.

","imageUrl":"https://assets.mrmed.in/others/file-1674132415913-10337479-Alcohol.jpg"},{"id":"14da1a6c-e370-43e3-a456-9084160fed55","advice":"Liver","tag":"Consult your doctor","description":"

It is unknown whether Biovorin 50mg Injection can be used in patients with liver disorders. Consult your doctor if you have any liver diseases before starting the treatment.

","imageUrl":"https://assets.mrmed.in/others/file-1674132424807-417765861-Liver.jpg"},{"id":"0701744a-747f-414b-8536-751cedc18c69","advice":"Lungs","tag":"Consult your doctor","description":"

It is unknown whether Biovorin 50mg Injection can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.

","imageUrl":"https://assets.mrmed.in/others/file-1674132427859-226731771-Lungs.jpg"},{"id":"a116e244-871b-49d7-8599-dd2305a4d724","advice":"Driving","tag":"safe","description":"

It does not affect the ability to drive or operate heavy machinery after taking Biovorin 50mg Injection.

","imageUrl":"https://assets.mrmed.in/others/file-1674132431331-421990512-Driving.jpg"},{"id":"cd31494d-b7a6-486a-8583-aeb92ce35a9b","advice":"Pregnancy","tag":"Consult your doctor","description":"

There is a limited number of studies on the safety of Biovorin 50mg Injection during pregnancy, and it is unknown whether the medicine can be given during pregnancy. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant.

","imageUrl":"https://assets.mrmed.in/others/file-1674132401469-949914510-Pregnancy.jpg"}]}},{"id":"613b152f-ca1e-43f4-878c-c8bbc704b82d","type":"PARA","position":8,"content_placement":1,"data":{"heading":"Side Effects of Biovorin 50mg Injection","text":"

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Common

Diarrhea
Nausea
Vomiting
Inflammmed and sore mouth
Tiredness

Serious

Allergic reactions

"}},{"id":"99b13c5e-fa32-43b5-8713-f57cafced890","type":"PARA","position":9,"content_placement":1,"data":{"heading":"Word of Advice","text":"

If your doctor has told you that you have an intolerance to some sugars, contact your doctor before taking these medicinal products. Inform your doctor if you have vomited immediately after receiving the injection. If you accidentally take too much Biovorin 50mg Injection. contact your doctor and seek medical advice immediately. Do not stop taking this medicine unless your doctor tells you to. Your doctor will regularly do lab tests to check the effectiveness of the medicine.

"}},{"id":"1d84d5f9-eeda-4c5d-89aa-7d58ca5bcf6b","type":"FAQ","position":10,"content_placement":2,"data":{"heading":"FAQs about Biovorin 50mg Injection","faq_list":[{"id":"8335cff4-e20a-4970-afa0-6fef9996b834","question":"

Why is Biovorin 50mg Injection given 24 hours after methotrexate?

","answer":"

Biovorin 50mg Injection is usually administered 24 hours after methotrexate so that it does not interfere with the therapeutic effect of methotrexate. It can also be used in methotrexate overdose; it should be administered as soon as possible.

"},{"id":"fe749f36-ba87-4d86-8091-a2463db394aa","question":"

Can Biovorin 50mg Injection cause swelling?

","answer":"

Biovorin 50mg Injection may cause allergic reactions like rash, low blood pressure, wheezing, shortness of breath, and swelling of the face or throat.

"},{"id":"57b53a83-967c-418e-b33a-9650d1e2785b","question":"

Can Biovorin 50mg Injection cause seizures?

","answer":"

There is no evidence that Biovorin 50mg Injection cause seizures. But the medicine can affect the effect of seizure medication when administered concurrently. Inform your physician about all your medicines, including over-the-counter medications.

"},{"id":"bfa635f4-7808-41d4-99d9-0dfa9e99992a","question":"

How long does it take for Biovorin 50mg Injection to work?

","answer":"

Biovorin 50mg Injection starts acting on the body within 5 minutes of administration. However, this might vary with respect to dosage, the patient receiving the drug, and response to treatment.

"},{"id":"f12de59a-37b2-481d-ad5c-e854ec4b973a","question":"

What measures should be taken to ensure the prompt excretion of methotrexate during treatment with Biovorin 50mg Injection?

","answer":"

A healthcare professional will monitor you during the treatment with this medicine. Maintenance of urine output above 2,500 mL/24hr in adults by increasing oral or intravenous fluids 12 hours before and for 36 hours after the end of methotrexate infusion. To monitor the alkalinization of urine (this enhances drug excretion) so that the urinary pH is greater than 7.0 before methotrexate infusion. Foods, drinks, and drugs that may increase urinary acidity should be avoided during the therapy. Finally, blood methotrexate concentration should be measured at least 24, 48, and 72 hours after the initiation of the methotrexate infusion.

"}]}},{"id":"0d097f63-6b9c-4d6a-bb29-f33b5cae71d0","type":"PARA","position":11,"content_placement":3,"data":{"heading":"Fact Box of Biovorin 50mg Injection","text":"

Molecule name: Leucovorin Calcium

Therapeutic class:

1. Antineoplastics

2. Antidote

3. Rescue agents

Pharmacological class: Folic acid analogs

Indications:

1. Methotrexate overdose and toxicity

2. Prevent the harmful effects of methotrexate or similar medication

3. Anemia

4. Colorectal cancer

"}},{"id":"71c10e5d-2a3c-4f64-8029-1123733fb8ad","type":"PARA","position":12,"content_placement":3,"data":{"heading":"References","text":"

Calcium Folinate 10 mg/ml Injection - Summary of Product Characteristics (SmPC) - (emc) [Internet]. www.medicines.org.uk. 2020 [cited 2023 Apr 4]. Available from: https://www.medicines.org.uk/emc/product/1572/smpc
HIGHLIGHTS OF PRESCRIBING INFORMATION [Internet]. [cited 2023 Apr 4]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/020140s024lbl.pdf
Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Drug toxicity and poisoning, 12th edition, 2011, 86.
KD Tripathi, Essentials of Medical Pharmacology, Haematinics and erythropoietin, 7th edition, 2013, 611.

"}},{"id":"00a9b271-cbfa-4eb9-b766-fd4f1c7ebed5","type":"DISCLAIMER","position":13,"content_placement":5,"data":{"heading":"Disclaimer","text":"

MrMed’s primary intention is to ensure that its consumers get information that is reviewed by experts, accurate and trustworthy. The information and contents of this website are for informational purposes only. They are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of your doctor and discuss all your queries related to any disease or medicine. Do not disregard professional medical advice or delay in seeking it because of something you have read on MrMed. Our mission is to support, not replace, the doctor-patient relationship.

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