BIOVORIN 50MG INJECTION

Introduction: 

Biovorin 50mg Injection contains the active constituent leucovorin calcium. It is used to reduce the side effects of a group of medicines called folic acid antagonists such as methotrexate (anticancer medicine), trimetrexate (antibiotic and anticancer medicine), trimethoprim (antibiotic) and pyrimethamine (antimalarial medication). It is used to treat megaloblastic anemias caused by folic acid deficiency. 

Biovorin 50mg Injection is also used to increase the effectiveness of fluorouracil (anticancer medicine). It is not recommended for patients with anemia caused by too little vitamin B12. Talk to your doctor if you are pregnant, breastfeeding, have had radiotherapy or stomach problems before taking this medicine. Large quantities of Leucovorin may diminish the chemotherapeutic effect of folic acid antagonists.

Make sure you inform your physician of all the medicines, including supplements and herbal medicines, you are taking before you start treatment with Biovorin 50mg Injection. Nausea, diarrhea, and vomiting are very common side effects of this medicine.

Uses of Biovorin 50mg Injection:

• An antidote to the overdose of folic acid antagonists
• Megaloblastic anemia
• Palliative treatment in combination with 5-fluorouracil for advanced colorectal cancer

How Biovorin 50mg Injection works: 

It is an essential coenzyme for nucleic acid synthesis, selectively protect cells from adverse effects of folic acid antagonists and increase the efficacy of fluorouracil.

Interactions with other drugs:

Inform your doctor about any medications you are taking or have taken before the treatment.

More information:

• Store below 30°C. 
• Keep out of sight and reach of children. 

References:

1. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Drug toxicity and poisoning, 12th edition, 2011, 86.
2. KD Tripathi, Essentials of Medical Pharmacology, Haematinics and erythropoietin, 7th edition, 2013, 611.
3. Bedford laboratories, US Food and Drug Administration, [ Revised on Nov 2011], [ Accessed on April 2021], https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/040347s010lbl.pdf
4. Hospira UK Limited, Electronics Medicines Compendium (emc), [ Revised on Feb 2021], [ Accessed on June 2021], https://www.medicines.org.uk/emc/files/pil.1572.pdf
5. 5. Vishwajit S. Hegde, Shivaraj Nagalli; Leucovorin; Updated on 08/07/2021; Accessed on 08/12/2021; https://www.ncbi.nlm.nih.gov/books/NBK553114/

How to use Biovorin 50mg Injection:

It will be given to you by your health care professional.

Safety advice:

Pregnancy: 

Inform your doctor if you are pregnant or planning to get pregnant before taking Biovorin 50mg Injection.

Breastfeeding:

Inform your doctor if you are breastfeeding before taking this medicine.

Other:

• Inform your doctor if you have stomach problems, have had radiotherapy, allergic conditions or other diseases.

Side effects are unwanted symptoms caused by medical treatment. Although all medicines can cause side effects, everyone will not get them. 

Serious:                   

• Fainting
• Seizures
• Gastrointestinal  toxicity
• Urticaria and Anaphylactic reactions

Common:

• Nausea, vomiting,
• Diarrhea
• Constipation
• Low blood count
• Infection
• Lethargy, fatigue
• Hair loss
• Dermatitis
• Anorexia