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Bivastat 250mg Injection
Last updated on 16 Jul 2026 | 02:10 PM (IST)
₹6257
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1 VIAL(s) OF 5ML
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₹6257
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Introduction to Bivastat 250mg Injection
Bivastat 250 mg injection contains an active component called Bivalirudin. It is a medication used in cardiology and is primarily employed as an anticoagulant (blood thinner). It is often used in patients who are undergoing certain medical procedures, such as percutaneous coronary intervention (PCI) or angioplasty, to reduce the risk of blood clots forming during the procedure. It is often used as an alternative to heparin in patients at risk of or with a history of heparin-induced thrombocytopenia (HIT), a potentially serious complication of heparin therapy.
Patients who have a known hypersensitivity or allergy to Bivalirudin or any of its components should not receive the medication. It is an anticoagulant and can increase the risk of bleeding. It is contraindicated in patients with active, severe, or life-threatening bleeding, such as gastrointestinal bleeding, intracranial bleeding, or bleeding disorders. It may not be suitable for patients with severely uncontrolled high blood pressure (hypertension). Patients with severe renal impairment or end-stage renal disease may require dosage adjustment or alternative anticoagulation strategies, as it can accumulate and increase the risk of bleeding. Patients with known coagulation disorders or conditions predisposing them to bleed may not be suitable for this medication. It is not recommended for patients with a significant decrease in platelet count (thrombocytopenia) or a history of heparin-induced thrombocytopenia (HIT) unless there are no suitable alternatives. It may not be appropriate for patients who have undergone recent major surgical procedures or experienced significant trauma due to the increased risk of bleeding. It is not recommended as the sole anticoagulant for patients with infective endocarditis or other conditions where a more extended duration of anticoagulation is needed. Bivastat 250 mg injection can be used in elderly patients, but with caution. It is not typically used in pediatric populations.
Uses of Bivastat 250mg Injection
- Percutaneous coronary intervention (PCI)
- Heparin-induced thrombocytopenia (HIT)
- Anticoagulation during cardiac surgery
Therapeutic Effects of Bivastat 250mg Injection
Bivastat 250 mg injection directly inhibits thrombin, a critical enzyme in the blood clotting process. Blocking thrombin prevents the conversion of fibrinogen into fibrin, effectively inhibiting blood clot formation. This mechanism is particularly useful in medical procedures like percutaneous coronary intervention (PCI) to maintain blood flow in coronary arteries while minimizing the risk of clot formation, thanks to its rapid onset and reversible effects.
Interaction of Bivastat 250mg Injection with other drugs
Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Bivastat 250 mg injection, reducing effectiveness by causing undesirable side effects.
More Information about Bivastat 250mg Injection
- Store at room temperature, between 20-25°C
- Keep away from moisture, heat, and light.
- It should not be frozen.
- Keep away from children and pets.
How to consume Bivastat 250mg Injection
Bivastat 250 mg injection is administered via the intravenous (IV) route. It is important to follow the dosing instructions provided on the product's packaging or as your healthcare provider recommends.
Safety Advice for Bivastat 250mg Injection
Breast Feeding
Bivastat 250 mg injection may be present in breast milk in small amounts, and its effects on nursing infants are poorly studied. It is advisable to consult your healthcare provider.
Alcohol
Alcohol can increase the risk of bleeding, and it is generally unsafe alcohol consumption while taking Bivastat 250 mg injection.
Liver
If you have liver-related medical conditions. It is important to consult with a healthcare professional before using Bivastat 250 mg injection if you have any liver-related concerns.
Lungs
Bivastat 250 mg injection primarily affects the blood's clotting ability and does not directly affect the lungs. it's advisable to consult your healthcare provider.
Driving
Bivastat 250 mg injection does not typically impair cognitive or motor function. If you experience bleeding or side effects that affect your ability to drive or operate machinery, consult your healthcare provider.
Pregnancy
Bivastat 250 mg injection may be used in pregnant women only if the potential benefits outweigh the risks and under the supervision of a healthcare provider.
Side Effects of Bivastat 250mg Injection
Bivastat 250 mg injection causes some side effects like all medications, although not everyone will experience them.
Serious:
- Bleeding
- Allergic reactions
- Thrombosis
Common:
- Bleeding
- Pain at injection site
- Headache
Word of Advice
Bivastat 250 mg injection increases the risk of bleeding, so careful monitoring is crucial, especially in patients with kidney problems who may need dosage adjustments. While it has minimal impact on liver function, severe liver disease should still be monitored. Verify any allergies to heparin and take steps to prevent blood clot formation with appropriate dosing and monitoring. Be cautious of potential drug interactions, be prepared to manage allergic reactions, and use this medication during pregnancy or breastfeeding only when the benefits outweigh the risks. Limited data are available for pediatric use, and elderly patients may require extra monitoring. Additionally, be careful with alcohol consumption and avoid driving or operating heavy machinery if experiencing dizziness or other side effects.
FAQs about Bivastat 250mg Injection
Q1.
Is there an antidote for Bivastat 250 mg injection?
Unlike some other anticoagulants like heparin, Bivastat 250 mg injection does not have a specific antidote. In cases of severe bleeding or the need for rapid reversal, healthcare providers may use supportive measures, such as blood transfusions or other agents, to counteract its effects.
Q2.
Can I discontinue Bivastat 250 mg injection on my own once my procedure is complete?
No, it is crucial to follow your healthcare provider's instructions regarding the discontinuation of Bivastat 250 mg injection. Stopping the medication abruptly without guidance can increase the risk of clot formation or other complications.
Q3.
Are there any dietary restrictions while taking Bivastat 250 mg injection?
There are no specific dietary restrictions associated with Bivastat 250 mg injection. However, it's essential to maintain a balanced diet and stay hydrated, as overall health plays a role in recovery from medical procedures.
Q4.
How long does the anticoagulant effect of Bivastat 250 mg injection last?
Bivastat 250 mg injection has a relatively short half-life, which allows for rapid onset and offset of its anticoagulant effects. The duration of its effect can vary depending on the dosage and individual patient factors.
Q5.
What should I do if I miss a dose of Bivastat 250 mg injection?
Bivastat 250 mg injection is typically administered under medical supervision, so the likelihood of missing a dose is minimal. However, if you have concerns about missed doses, discuss them with your healthcare provider for guidance on how to proceed.
Q6.
What are the common side effects of Bivastat 250 mg injection?
Common side effects of Bivastat 250 mg injection can include bleeding (both minor and major), pain at the injection site, and headache.
Fact Box of Bivastat 250mg Injection
Molecule name: Bivastat 250 mg injection | Therapeutic class: Antithrombotic agents |
Pharmacological class: Direct Thrombin Inhibitors | Indications: 1. Percutaneous coronary intervention (PCI) 2. Heparin-induced thrombocytopenia (HIT) 3. Anticoagulation during cardiac surgery |
References
- KD Tripathi, Essentials of Medical Pharmacology, Drugs affecting coagulation, bleeding and thrombosis, 7th edition, 2013, 617, 620.
- Medicines company, US Food and Drug Administration, [ Revised on March 2016], [ Accessed on April 2021], https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/020873s036lbl.pdf
- Accord Healthcare, Electronics Medicine compendium (EMC), [ Revised on May 2016], [ Accessed on 27th Sept 2023], https://www.medicines.org.uk/emc/files/pil.7229.pdf
Disclaimer
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Author Details
Written By
Dr. Archana Gupta
BDS
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 16 Jul 2026 | 02:10 PM (IST)
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