Botox 50IU Injection is used for:

• Treatment of overactive bladder with symptoms such as urinary urgency, frequency and urge urinary incontinence in adults

• Prevention of headaches in adults with chronic migraine

• Treatment of spasticity in adults

• Treatment of cervical dystonia in adults

• Treatment of severe underarm sweating in adults

• Treatment of blepharospasm associated with dystonia

• Treatment of strabismus

Botox contains botulinum toxin type A, which acts on nerve endings at the injection site.

It prevents the release of acetylcholine, a chemical messenger involved in muscle contraction and the activity of certain glands. This temporarily reduces excessive muscle contraction or gland activity, depending on where the medicine is injected.

The effect is temporary, and nerve function gradually returns as new nerve connections develop.

Tell your doctor about all prescription medicines, over-the-counter medicines, vitamins and herbal supplements you take.

• Aminoglycoside antibiotics: Medicines such as gentamicin or amikacin may enhance the effects of botulinum toxin on neuromuscular transmission.

• Muscle relaxants: These may increase muscle weakness when used with Botox.

• Other botulinum toxin products: Using different botulinum toxin products within a short interval may increase the risk of excessive muscle weakness.

• Medicines affecting neuromuscular transmission: Tell your doctor about any medicines that may affect nerve and muscle function.

Your doctor will decide whether any medicine needs to be stopped or adjusted before treatment.

• Store unopened Botox 50IU Injection in a refrigerator at 2°C to 8°C.

• Do not freeze the unopened vial.

• Keep the vial in its original packaging and protect it from light.

• After reconstitution, store the solution in a refrigerator at 2°C to 8°C and use it within the period specified in the product information.

• Do not use the medicine if the vial or packaging is damaged.

• Keep the medicine out of the sight and reach of children.

The original content incorrectly states that the unopened medicine may be stored in a freezer. Botox should not be frozen.

Botox 50IU Injection should only be administered by a trained healthcare professional.

The powder is reconstituted with sterile, preservative-free 0.9% sodium chloride solution before administration. Depending on the condition being treated, Botox may be injected into specific muscles, the bladder wall or the skin.

The dose and number of injection sites vary according to the condition. Do not attempt to administer Botox yourself.

Common side effects may include:

• Pain, swelling, irritation or bruising at the injection site

• Headache

• Tiredness

• Muscle weakness

• Muscle or limb pain

• Nausea

• Dry mouth

• Fever

• Rash or itching

• Urinary tract infection, depending on the treatment site

• Upper respiratory tract infection

Serious side effects

Seek immediate medical attention if you develop:

• Difficulty swallowing

• Difficulty speaking

• Difficulty breathing

• Severe or widespread muscle weakness

• Allergic reactions

• Vision problems

• Significant weakness away from the injection site

• Urinary retention following treatment for bladder problems

Botulinum toxin effects can occasionally spread beyond the injection area and cause serious symptoms.

• Botox should only be administered by a healthcare professional trained in the appropriate injection technique.

• The dose varies substantially depending on the condition being treated. Do not compare doses between different conditions.

• Tell your doctor about previous botulinum toxin treatment and any reactions you experienced.

• Inform your doctor if you have difficulty swallowing or breathing or have a neuromuscular disorder.

• Tell your doctor about all medicines you take, particularly antibiotics and muscle relaxants.

• Do not receive another botulinum toxin product without informing your doctor.

• Seek immediate medical attention if you develop difficulty swallowing, speaking or breathing after treatment.

• Follow the recommended treatment interval because repeated treatment too frequently may increase the risk of complications.