Bryxta 400mg Injection is indicated to treat the following conditions:

• Glioblastoma multiforme (brain cancer)

• Persistent, recurrent, or metastatic breast cancer

• Metastatic cervical cancer

• Advanced kidney cancer

• Metastatic colorectal cancer

• Advanced non-small-cell lung cancer

• Liver Cancer- Hepatocellular carcinoma

• Cancers of the ovary, cervical, fallopian tube, or primary peritoneal cancer

Bryxta 400mg Injection is a recombinant humanized monoclonal antibody that works as a targeted therapy in the treatment of various advanced cancers. It produces its action by selectively binding to the protein called vascular endothelial growth factor A (VEGF-A), present in the lining of blood and lymph vessels in the body. It interrupts the interaction of VEGF-A with its receptors. This further inhibits the formation of blood vessels that supply oxygen and nutrients to the tumor. As a result, it slows down the rate of progression of cancer.

Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional and vitamin supplements, and herbal products you take or have taken before the treatment. Certain medications may interact with Bryxta 400mg Injection and cause undesirable side effects.

• Store Bryxta 400mg Injection at 2˚C to 8˚C. Do not freeze or shake.

• Protect from light. Keep out of reach of children.

Your physician or nurse will administer Bryxta 400mg Injection as an intravenous infusion. The infusion should be given immediately after the dilution.

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.

Serious: 

• Headache

• Vision changes

• Confusion

• Severe allergic reactions

• High Blood pressure

• Delayed wound healing following surgery

• Protein in urine

• Severe infections

• Blood clots in arteries and blood vessels of lungs

• Gut perforation

• Nosebleeds and bleeding risk

• Heart problems with an increase in heart rate

• Mouth sores, dryness

• Shortness of breath

Common:

• Numbness in hands or feet

• Weakness and lack of energy

• Diarrhoea, nausea, vomiting, abdominal pain

• Constipation

• Loss of appetite

• Weight loss

• Changes in taste and speech

• Decrease in counts of white blood cells

• Fever

• Dry skin

• Back pain

It is vital to inform your physician before taking Bryxta 400mg Injection if you have the following conditions:

• Have conditions involving inflammation in the stomach (ulcer, colitis).

• Experience allergic reactions to Bryxta 400mg Injection or its ingredients.

• Have recently undergone surgery as it is associated with the risk of bleeding.

• Have diabetes, hypertension, or heart problems.

1. Roche Products Limited, Electronic Medicines Compendium (EMC), [Revised on Jan 2022] [Accessed on 21/11/2022], https://www.medicines.org.uk/emc/files/pil.3885.pdf 
2.  G.G. Dark, A.R. Abdul Razak, Oncology, Davidson's Principles & Practice of Medicine, 22nd Edition, 2014, 259-282.
3. KD Tripathi, Anticancer Drugs, Essentials of Medical Pharmacology, 8th Edition, 2019, 915-936.
4. Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976. 
5. Roche Group, U.S FDA, [Revised on Jan 2021][ Accessed on 21/11/2022], https://www.gene.com/download/pdf/avastin_prescribing.pdf 
6. Roche Group,Bevacizumab Injection, Indication,[Revised on 2020] [Accessed on 21/11/2022]https://www.avastin.com/patient/mcrc.html