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Bucelon 2mg Tablet
Prescription Required
Salt Composition : Busulfan
Manufacturer : CELON LABORATORIES LTD
Origin of Medicine : India
25 Tablet(s) In A Bottle
Introduction to Bucelon 2mg Tablet
Bucelon 2 mg tablet is an anti-cancer (antineoplastic/cytotoxic) chemotherapy drug. It is an alkyl sulfonate belonging to the class alkylating agent. It is indicated for treating blood cancers, such as chronic myelogenous leukemia (A type of cancer that causes an increase in white blood cells). It is given as a treatment to prepare the bone marrow to receive healthy blood-forming cells (stem cells) from a donor to replace their stem cells that have been destroyed by treatment with radiation or high doses of chemotherapy).Â
Chronic myelogenous leukemia is an uncommon type of cancer that affects bone marrow (soft, spongy tissue that produces blood cells for your body). It causes an increase in white blood cell count. Common side effects of Bucelon 2 mg tablets are decreased white blood cells, dizziness, shortness of breath, mouth inflammation, nausea, diarrhea, difficulty sleeping, and fever. Drink plenty of fluids while you are taking this medicine.  Â
Bucelon 2 mg can cause a severe decrease in bone marrow activity. If you are taking any other prescribed or non-prescribed medications that decrease the blood cell count, talk to your healthcare professional before taking the medications. Busulfan tablets affect your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, cough, mouth sores, or unusual bleeding or bruising.
Uses of Bucelon 2mg Tablet
- Hematopoietic progenitor cell transplantation
- Chronic myelogenous leukaemia
- Polycythaemia vera (type of cancer that causes increase in red blood cells)
- Thrombocythemia (increased number of platelets in the blood)
- Myelofibrosis (type of blood cancer where scar tissues are formed in bone marrow)
- Hemoglobinopathies (a genetic disorder that produces abnormal haemoglobin)
Therapeutic Effects of Bucelon 2mg Tablet
Bucelon works by interfering with the DNA replication process, which is necessary for the cells to divide. It stops tumor growth by inhibiting cell division. They cause cytotoxicity by reversibly binding to nucleophilic groups on different cell components. Alkylation of DNA is most likely the crucial cytotoxic reaction that kills tumor cells. It damages the DNA and RNA of the cancer cells by stopping their growth and multiplication. They are combined with other medications to treat various lymphatic and solid cancers.
Interaction of Bucelon 2mg Tablet with other drugs
Inform your physician regarding any prescribed medicines, over-the-counter medications, nutritional or vitamin supplements, and herbal products that you are taking or have taken before the treatment. Certain medications may interact with Bucelon 2mg Tablet and can cause potential side effects.Â
More Information about Bucelon 2mg Tablet
Store it at room temperature and away from excess heat and moisture. Store at 15° to 25°C (59° to 77°F) in a dry place. Keep it out of sight and reach of children.Â
How to consume Bucelon 2mg Tablet
Your physician will decide the dose and duration of this therapy. The dose of Busulfan depends on your blood cancer. Swallow the tablets with plenty of water. Do not break, crush or chew them. You can take busulfan tablets before or after meals. Don't stop the medication until or unless your doctor advises. If you missed the dose, do not take double the doses. Inform your physician about your missed dose. Â
Safety Advices for Bucelon 2mg Tablet
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Pregnancy
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Bucelon 2mg is unsafe during pregnancy. It may cause fetal harm when administered. If you are pregnant or planning to get pregnant, ask your doctor or pharmacist for advice before taking this medicine. This applies to men and women because the drug may harm your sperm or eggs.
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Breast Feeding
 ÂIf you are breastfeeding or plan to breastfeed your baby, talk to your physician because the drug may secrete in breast milk.
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Lungs
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It is unknown whether Bucelon 2mg Tablet can be given to patients with lung diseases. Please inform your doctor if you have any lung problems.Â
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Liver
  Discuss with your physician before taking this medicine if you have liver problems.Â
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Alcohol
 ÂIt is not known whether it is safe to consume alcohol with Bucelon 2 Tablet. Please consult your doctor.Â
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Driving
  It is not known whether Bucelon 2 Tablet alters the ability to drive. Do not drive if you experience symptoms affecting your ability to concentrate and react.
Side Effects of Bucelon 2mg Tablet
Side effects are unwanted symptoms caused by medicines. Even though all medications cause side effects, not everyone gets them.Â
Severe
- Myelosuppression (decreased bone marrow activity)Â
Common side effects
- Thalassaemia
- Hair loss
- Patches of dark skin
- Blood in urine
- Decrease in the number of blood cells and platelets
- Nausea and vomiting
- Jaundice
- Infertility and sterility
- Pneumonia syndrome
Word of Advice
Inform the doctor if the patient has taken radiotherapy priorly to the treatment. If you have other medical conditions like heart disease, lung, kidney, or liver problems. Tell your doctor if you have gout symptoms (pain and swollen joints caused by uric acid crystals).Â
FAQs
Q 1. Can Bucelon 2 mg tablets cause infertility?
Yes, bucelon 2 mg tablets can cause infertility in both the men and women because it affects the sperm cells and egg. Consult the doctor before taking this medication.
Q 2. How can a Busulfan 2 mg tablet be taken?
Bucelon 2 mg tablet is taken orally. Swallow the whole tablet with water. If you have missed the dose, inform your physician. Don't take double the dose.
Q 3. Can bucelon 2 mg be used during pregnancy?
No, it is highly unsafe to use this medication during pregnancy as they can cause harmful effects on the developing fetus.
Q 4. Are there any special precautions patients should be aware of before starting treatment?
Patients should inform the physician about the pregnancy, breastfeeding, or if planning for a family. Patients should also inform about past medical and medication history.
Q 5. What is the package insert that comes with Bucelon 2 mg?
The package insert contains all the scientific information(indications, uses, side effects, safety, and warning, contraindications) about the drug.
Q 6. Does bucelon 2mg cause permanent hair loss?
Yes, Bucelon 2 mg tablet chemotherapy causes hair loss. Consult the physician about excessive hair loss.
Q 7. What does a bucelon 2 mg tablet look like?
It looks like a white, scored tablet packed in a bottle containing 25 tablets per bottle.
Fact Box of Bucelon 2mg Tablet
| Molecule Name: Busulfan | Therapeutic class: Anticancer  |
| Pharmacological class: Alkylating agent - Alkyl sulfonates | Indication: 1. Chronic myelogenous leukemia 2. Hematopoietic progenitor cell transplantation 3. Polycythaemia vera 4. Thrombocythemia 5. Myelofibrosis 6. Hemoglobinopathies 7. Congenital metabolic diseases |
References
- Aspen, Electronic Medicines Compendium(EMC) (Revised on: July 2020) https://www.medicines.org.uk/emc/product/4653/pil#gref  (Accessed: December 14, 2022).
- Busulfan (Revised on: May 19, 2015) National Cancer Institute. https://www.cancer.gov/about-cancer/treatment/drugs/busulfan  (Accessed: December 14, 2022).
- Anton Wellstein, Giuseppe Giaccone, Michael B. Atkins, and Edward A. Sausville, Pharmacotherapy of Neoplastic disease: cytotoxic drugs, Goodman & Gilman’s Pharmacological Basis of Therapeutics, 13th Edition, 2018, 1167-1174.
- Buggia I, Locatelli F, Regazzi MB, Zecca M. Busulfan. Ann Pharmacother. 1994 Sep;28(9):1055-62. doi: 10.1177/106002809402800911. PMID: 7803883.
Disclaimer
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