• Hematopoietic progenitor cell transplantation
• Chronic myelogenous leukemia
• Polycythaemia vera (a type of cancer that causes an increase in red blood cells)
• Thrombocythemia (increased number of platelets in the blood)
• Myelofibrosis (type of blood cancer where scar tissues are formed in bone marrow)
• Hemoglobinopathies (a genetic disorder that produces abnormal hemoglobin)
• Brain Malignancies

Bucelon 60 mg injection works by interfering with the DNA replication process, which is necessary for the cells to divide. It stops tumor growth by inhibiting cell division.  It causes cytotoxicity by reversibly binding to nucleophilic groups on different cell components. Alkylation of DNA is most likely the crucial cytotoxic reaction that kills tumor cells. It damages the DNA and RNA of the cancer cells by stopping their growth and multiplication. They are combined with other medications to treat various lymphatic and solid cancers.

Inform your physician regarding any prescribed medicines, over-the-counter medications, nutritional or vitamin supplements, and herbal products that you are taking or have taken before the treatment. Certain medications may interact with Bucelon 60mg Injection and can cause potential side effects. 

Unopened vials of bucelon 60 mg injection should be stored under refrigerated conditions between 2°C to 8°C (36°F to 46°F). Unused medications should be disposed of properly. Keep it out of sight and reach of children.

Your physician will decide the formulation, dose, and duration of this therapy. The dose of Bucelon 60 mg injection depends on your blood cancer. If you are prescribed the injection, your healthcare professional will administer the injection. Do not self-administer. The injection is administered as an intravenous infusion into the vein. Don't stop the medication until or unless your doctor advises. If you missed the dose, do not take double the doses. Inform your physician about your missed dose.

Side effects are unwanted symptoms caused by medicines. Even though all medications cause side effects, not everyone gets them. Bucelon 60 mg injection causes the following side effects 

Severe

Myelosuppression (decreased bone marrow activity) 

Common side effects 

• Thalassemia
• Skin rashes
• Hair loss
• Patches of dark skin
• Blood in urine
• Decrease in the number of blood cells and platelets
• Nausea and vomiting
• Jaundice
• Infertility and sterility
• Pneumonia Syndrome
• Itching

Inform the doctor if the patient has taken radiotherapy priorly to the treatment. If you have any other medical conditions like heart disease, lung, kidney, or liver problems. Tell your doctor if you have any symptoms of gout (pain and swollen joints caused by uric acid crystals). During or after administration of the injection, if you face itchy skin, fever, excessive sweating, rigors or chills, or difficulty in breathing, inform your doctor immediately.

1. Aspen, Electronic Medicines Compendium(EMC) (Revised on: July 2020) https://www.medicines.org.uk/emc/product/4653/pil#gref   (Accessed: December 14, 2022).
2. Busulfan (Revised on: May 19, 2015) National Cancer Institute. https://www.cancer.gov/about-cancer/treatment/drugs/busulfan   (Accessed: December 14, 2022).
3. Anton Wellstein, Giuseppe Giaccone, Michael B. Atkins, and Edward A. Sausville, Pharmacotherapy of Neoplastic disease: cytotoxic drugs, Goodman & Gilman’s Pharmacological Basis of Therapeutics, 13th Edition, 2018, 1167-1174.
4. Buggia I, Locatelli F, Regazzi MB, Zecca M. Busulfan. Ann Pharmacother. 1994 Sep;28(9):1055-62. doi: 10.1177/106002809402800911. PMID: 7803883.