BUFATAS IV 60MG INJECTION

Introduction:

Bufatas 6mg/ml Injection is a potent cytotoxic agent that belongs to the class of alkylating agents. It is used as a treatment before transplantation in new-born, children and adults. It destroys the original bone marrow before the transplant. Inform your physician if you are taking medicines to cure certain infections or if you have taken Paracetamol in the past 72 hours.

Uses of Bufatas 6mg/ml Injection:

Indicated as an adjuvant drug to chemotherapy and radiotherapy before hematopoietic progenitor cell transplantation in the following conditions:

• Acute lymphocytic leukemia and acute non-lymphocytic leukemia.
• Acute myeloid leukemia and chronic myeloid leukemia
• Hodgkin’s disease and non-Hodgkin’s lymphoma
• Multiple myeloma and myelodysplastic syndrome

How Bufatas 6mg/ml Injection Works:

Bufatas 6mg/ml Injection works by suppressing all blood elements and stem cells and this effect lasts for a few months or years. It produces cross linking of DNA and damages the chromosome, preventing the further division of cancer cells and stops its multiplication.

Interaction with other drugs:

Inform your doctor about any medications you are taking or have taken before the treatment.

More Information:

Sealed vials should be stored in a refrigerator (2-8°C). If diluted in 0.9% sodium chloride or 5% dextrose solution, Bufatas 6mg/ml Injection shall be stored at a room temperature for not more than 8 hours and in a refrigerator for not more than 12 hours. Do not freeze.

References:

1. Apotex Inc., [Revised on 15th Feb 2018] [Accessed on 9th Apr 2021], https://pdf.hres.ca/dpd_pm/00043959.PDF
2. Tillomed Laboratories Limited, Electronic Medicines Compendium (EMC) [Revised on Jan 2021] [Accessed on 2nd Dec 2021], https://www.medicines.org.uk/emc/files/pil.11731.pdf
3. Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.
4. Anton Wellstein, Giuseppe Giaccone, Michael B. Atkins, and Edward A. Sausville, Cytotoxic Drugs, Goodman & Gilman's The Pharmacological Basis of Therapeutics, 13th Edition, 2018, 1167-1201. 

How to use Bufatas 6mg/ml Injection: 

Bufatas 6mg/ml Injection should be administered only under the supervision of a qualified healthcare professional. 

Safety Advice:

Pregnancy:

Bufatas 6mg/ml Injection can be harmful to the fetus. Hence it is not intended for use during pregnancy. In case you are pregnant or think you might be pregnant, consult your physician for advice.

Breastfeeding: 

Consult your physician before you take this medicine if you are a breastfeeding mother.

Liver: 

Inform your physician if you have undergone prior radiation therapy or three cycles of chemotherapy, or a prior progenitor cell transplant.

Kidney: 

Inform your physician before Bucelon 60mg Injection therapy if you have kidney problems.

Driving:

Avoid driving or using machines if you feel dizzy.

Allergies:

Before you take this medicine, inform your doctor if you have experienced allergic reactions to Busulfan or any of its ingredients.

Others:

• Inform your physician before starting treatment with Bucelon 60mg Injection if you have a history of seizures, lung disorders, or heart problems. 

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Serious:

• Decrease in circulating blood cell counts (RBC, WBC, Platelets)
• Infection
• Liver disorder
• Lung complications
• Graft vs. host disease

Common:

• Sleeplessness, anxiety, dizziness and depression
• Loss of appetite, low levels of calcium, magnesium, potassium, phosphate, albumin in the blood
• Increase in blood glucose levels
• Increased heart rate, fluctuating BP and blood clots
• Breathlessness, sore throat, cough, hiccups, nose bleeds
• Nausea, vomiting, stomach pain, diarrhea, heartburn, constipation.
• Skin rashes, itching and hair loss
• Back, muscle and joint pain
• Chest pain, fever and weight gain