CADSONIB 200MG TABLET 30'S

Introduction:

Cadsonib 200mg Tablet consists of the active ingredient Sorafenib that is indicated for advanced renal cell carcinoma (kidney cancer), advanced hepatocellular carcinoma (liver cancer) in patients ineligible for surgery and differentiated thyroid carcinoma (thyroid cancer) in patients who are not responsive to radioactive iodine therapy.

Vascular endothelial growth factor (VEGF) interacts with its receptor to generate angiogenesis (making of blood vessels), which ultimately facilitates the growth and spread of cancer. This medicine acts against the overexpression of these receptors that is common in several types of cancer. Before starting treatment with Cadsonib 200mg Tablet, you should let your physician know if you have heart problems, chest pain, bleeding problems, high blood pressure, or have had or are about to have surgery. 

Use effective contraception during the therapy and for 6 months after the last dose if you are a woman or 3 months after the last dose if you are a man. Diarrhea, tiredness, appetite loss, nausea, weight loss, and low blood calcium levels are common side effects of Cadsonib 200mg Tablet.

Uses of Cadsonib 200mg Tablet:

Cadsonib 200mg Tablet is used to treat:

• Advanced renal cell carcinoma
• Advanced hepatocellular carcinoma that cannot be surgically treated
• Advanced papillary and follicular Hurtle cell thyroid carcinoma

How Cadsonib 200mg Tablet works:

Sorafenib is a small molecule that works by inhibiting multiple receptor tyrosine kinases (enzymes), primarily vascular endothelial growth factor receptors and platelet-derived growth factor-β receptors. This prevents the development of blood vessels in tumor cells (angiogenesis) and arrests the growth and spread of the tumor cells to other organs.

Interaction with other drugs:

Inform your doctor about any medications you are taking or have taken before the treatment.

More Information:

Store below 30°C in a dry place.

References:

1. Bayer (Pty) Ltd, [Revised on 22nd Apr 2016] [Accessed on 8th Jun 2022], https://www.bayer.com/sites/default/files/NEXAVAR_200_EN_PI.pdf
2. Bayer HealthCare Pharmaceuticals Inc., US Food & Drug Administration, [Revised on Dec 2018] [Accessed on 8th Jun 2022], https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/021923s020lbl.pdf
3. Ciplamed, [Revised on Dec 2017] [Accessed on 8th Jun 2022], https://www.ciplamed.com/print-product-pdf/24207
4. Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.
5. KD Tripathi, Anticancer Drugs, Essentials of Medical Pharmacology, 8th Edition, 2019, 915-936.

How to use Cadsonib 200mg Tablet:

Take the tablet without food (1 hour before or 2 hours after meal). Swallow with a glass of water.

Safety Advice:

Pregnancy:

It is unsafe to use Cadsonib 200mg Tablet during pregnancy as it may harm the unborn baby. Inform your physician before starting this treatment if you are pregnant or think you might be pregnant. Your physician will conduct a pregnancy test before prescribing this medicine for you.

Breastfeeding: 

Do not breastfeed during treatment with Cadsonib 200mg Tablet and for two weeks after the last dose. It is vital to let your physician know if you are breastfeeding or planning to breastfeed before starting treatment with this drug. 

Kidney:

Inform your physician before starting this treatment if you have kidney diseases. Your physician will monitor your fluid balance and electrolyte levels.

Driving: 

This medicine could cause peripheral sensory neuropathy that causes an impact on driving. Hence, avoid driving or doing things that require focus during this treatment period.

Others:

• Inform your physician before starting this treatment if you have heart problems, abnormal levels of potassium, magnesium, calcium in the blood, bleeding problems, high BP, or if you are about to undergo surgery.
• Use effective contraception during the therapy and for 6 months after the last dose if you are a woman or 3 months after the last dose if you are a man.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Serious:

• Stevens Johnsons Syndrome and toxic epidermal necrosis
• Decreased blood flow to the heart
• Increased risk of bleeding (blood in urine, stool, vomit, cough, etc)
• High BP
• Skin problems
• Liver problems
• Problem in wound healing

Common:

• Nausea, stomach pain, diarrhea
• Tiredness and weakness
• Infection
• Hair thinning and patchy hair loss
• Rash
• Weight loss
• Loss of appetite
• Low levels of calcium in the blood
• Flu-like illness