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Celrixafor 24mg Injection
Salt Composition : Plerixafor
Manufacturer : CELON LABORATORIES LTD
Origin of Medicine : India
1 Vial(s) Of 1.2ml
Introduction to Celrixafor 24mg Injection
Celrixafor 24mg injection is an antineoplastic containing the active ingredient Plerixafor. It is used in collecting blood stem cells, storage, and transplantation. It is also used in lymphoma (WBC cancer), multiple myeloma (plasma cell cancer in bone marrow), or a solid tumor. Talk to your doctor if you have or had any heart disease. Before starting the treatment, notify your doctor if you have high WBC counts, low platelet counts, or a history of usual lightheaded or fainting, especially before injection. It is not advised to take this medicine for stem cell mobilization if you have leukemia.
Do not take this tablet if you are allergic to Plerixafor or any other medicine ingredients. Notify your doctor if you have kidney disorders; your doctor may adjust the dose of the Celrixafor 24mg if you have existing kidney disease. Your doctor may also perform a regular blood test to monitor the blood cell count. Do not take this tablet if you are pregnant or planning to get pregnant or think you might be pregnant, or if you are breastfeeding. It is recommended to use effective contraception. Report to your doctor if you experience any side effects like rashes or swelling around your eyes, a change in breathing (lack of oxygen), or pain in the abdomen (upper left) or left shoulder.
Uses of Celrixafor 24mg Injection
- Collect blood stem cells
- Lymphoma and multiple myeloma in adults
- Lymphoma or solid tumors in children (aged between 1 to 18)
Therapeutic Effects of Celrixafor 24mg Injection
Celrixafor 24mg injection works by blocking a protein called CXCR4 (chemokine receptor) on stem cells, which helps them move from the bone marrow into the bloodstream. By blocking CXCR4, Celrixafor 24mg causes the stem cells to be released into the bloodstream, where the stem cells can be collected and isolated using a machine and stored for transplantation.
Interaction of Celrixafor 24mg Injection with other drugs
Inform your healthcare professional about all the medicines you take, including prescription, over-the-counter, nutritional and vitamin supplements, and herbal products. Certain medications interacting with Celrixafor 24mg may reduce effectiveness by causing undesirable side effects.
More Information about Celrixafor 24mg Injection
- Keep Celrixafor 24mg injection out of sight and reach of children and pets.
- This tablet does not require any special storage conditions.
- It should be used immediately if the vial is opened.
- Do not refrigerate or freeze.
How to consume Celrixafor 24mg Injection
Celrixafor 24mg injection is administered as a subcutaneous injection (under your skin). If this drug is recommended for you, it will be given by a doctor. Do not self-administer. Your doctor will choose the dosage and administration frequency based on the condition because it differs from person to person.
Safety Advices for Celrixafor 24mg Injection
Celrixafor 24mg injection can cause harm to your unborn baby. Report to your doctor if you are pregnant or planning to get pregnant before taking the injection. Use effective contraception.
You must not breastfeed while being treated with Celrixafor 24mg injection. Inform your physician if you are breastfeeding before taking this treatment.
Consult your doctor immediately if you experience any symptoms like difficulty in breathing. Contact your doctor for more lung-related concerns.
There is not much information currently accessible on the use of Celrixafor 24mg injection in patients with liver illness, Please speak with your physician.
It is not recommended to take alcohol while under this treatment because it may cause drowsiness and sleepiness. Talk to your doctor for more information.
Celrixafor 24mg injection could affect your ability to drive. Avoid driving while taking this medicine. Talk to your doctor for more information.
Side Effects of Celrixafor 24mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.
- Rashes and swelling around the eyes
- Difficulty in breathing
- Upper left abdomen pain
- Left shoulder pain
- Redness or irritation in the injection site
- Low RBC count (anemia)
- Constipation, indigestion
- Dry mouth, numbness
- Joint pains
- Difficulty in sleeping
Word of Advice
You need to tell your doctor if you have any kidney disorders before taking Celrixafor 24mg Injection. Your physician may decide to adjust the dose or delay treating you depending on your kidney function. Please consult your doctor before starting this injection, and getting suggestions about fertility concerns from your doctor is recommended. Your doctor may take regular blood tests to monitor your liver function and blood cell count.
Q 1. How can I manage the side effects related to Celrixafor 24mg use?
Managing side effects of Celrixafor 24mg can include taking anti-nausea medication, staying hydrated, and resting. If you experience any side effects, it is important to speak with a healthcare provider. Hence, visit your doctor immediately.
Q 2. Who should not take Celrixafor 24mg?
Celrixafor 24mg is not recommended for patients who have had an allergic reaction to Celrixafor 24mg or any of its ingredients. It is also not advised for patients with certain medical conditions, such as severe kidney problems or low white blood cell counts.
Q 3. How effective is Celrixafor 24mg in mobilizing stem cells?
Studies have shown that Celrixafor 24mg, in combination with G-CSF, is highly effective in mobilizing stem cells from the bone marrow into the bloodstream.
Q 4. What if I missed my dose of Celrixafor 24mg?
If you missed your regular injection, contact your doctor immediately.
Q 5. How is Celrixafor 24mg administered?
Celrixafor 24mg injection is given as a subcutaneous injection (injected under the skin), typically in the stomach or thigh.
Q 6. Why should I not consume alcohol while taking Celrixafor 24mg?
The liver metabolizes Plerixafor, and alcohol can also affect liver function. Therefore, consuming alcohol while taking Plerixafor can impact its effectiveness and increase the risk of liver damage. Also, alcohol can increase the risk of certain side effects associated with this medicine, such as dizziness, drowsiness, and lightheadedness.
Fact Box of Celrixafor 24mg Injection
Molecule name: Plerixafor
Therapeutic class: Antineoplastic
Pharmacological class: Hematopoietic Stem Cell Mobilizers
1. Collect blood stem cells
2. Lymphoma and multiple myeloma in adults
3. Lymphoma or solid tumors in children (aged between 1 to 18)
- Genzyme Corporation, U.S. Food & Drug Administration [Revised on Dec 2017] [Accessed on 13th April 2021] https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/022311s018lbl.pdf
- Seacross Pharmaceuticals Limited, Electronic Medicines Compendium (EMC), [Revised on Jan 2022] [Accessed on 20th April 2023], Plerixafor Seacross 20 mg/ml solution for injection - Patient Information Leaflet (PIL) - (emc) (medicines.org.uk)
- James L. Zehnder, Agents Used in Cytopenias; Hematopoietic Growth Factors, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 591- 607.
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