CLADRIM 10MG INJECTION

Introduction:

Cladrim 10mg Injection is a cancer medication containing the active constituent cladribine. It is used to treat Hairy Cell Leukemia (HCL) and B- cell chronic lymphocytic leukemia (CLL). In both HCL and CLL, white blood cells that engage in fighting infection grow in an abnormal and uncontrolled manner. 

You should inform your physician if you have kidney disorders, liver disorders, infection, fever, or blood disorders before taking Cladrim 10mg Injection. Tell your physician about all the medications you are taking recently and if you are about to have any live vaccinations before starting the treatment.

Use effective birth control during the treatment and for at least six months after the last dose. You need to discuss with your physician if you are on a salt-controlled diet as Cladrim 10mg Injection contains sodium. Headache, nausea, vomiting, and pain at the injection site are very common side effects of this drug.

Uses of Cladrim 10mg Injection:

• Hairy Cell Leukemia (HCL)
• B- cell chronic lymphocytic leukemia (CLL)

How Cladrim 10mg Injection works:

It is taken up by the multiplying cells, interferes with the DNA synthesis, and prevents the growth and spread of cancer cells.

Interactions with other drugs:

Inform your doctor about any medications you are taking or have taken before the treatment.

More information:

• Keep out of sight and reach of children.
• Store refrigerated at 2°C to 8°C.

References:

1. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Cytotoxic agents, 12th edition, 2011, 1703-1704.
2. Janssen-Cilag Ltd, Electronic medicines compendium (emc), [ Revised on Aug 2020] [ Accessed on 7th April], https://www.medicines.org.uk/emc/files/pil.1438.pdf
3. Centocor Ortho Biotech Products, US Food and Drug Administration, [ Revised on July 2012] [ Accessed on 7th April 2021], https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020229s034lbl.pdf

How to use Cladrim 10mg injection:

Cladrim 10mg injection will be administered by a health care professional.

Safety advice:

Pregnancy: 

There are no established adverse effects of Cladrim 10mg injection in pregnant women. As a precautionary measure, the use of this medicine should be avoided during the pregnancy. Inform your doctor if you are pregnant or planning to get pregnant before taking this medication. 

Breastfeeding:

Cladrim 10mg injection may be excreted into breast milk. Inform your doctor if you are breastfeeding before taking this medication.

Liver: 

Inform your doctor if you have any liver disorders before taking Cladrim 10mg injection.

Kidney:

Inform your doctor if you have any kidney disorders Cladrim 10mg injection.

Driving:

Caution should be exercised while driving during treatment with this medication.

Others:

• Inform your physician if you have fever, blood disorders, infection, or about to have any live vaccinations before taking Cladrim 10mg injection.

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.

Serious: 

• Septic shock (infection throughout the body)
• Malignancies
• Anemia
• Renal failure
• Bleeding
• Depressed level of consciousness
• Neurotoxicity
• Infection

Common: 

• Low white blood cells
• Allergic reactions
• Administration site reaction
• Confusion, Anxiety, Insomnia
• Headache, dizziness
• Eye infection
• Abnormal heart rate
• Cough, abnormal breath sounds
• Nausea, vomiting
• Abdominal pain, constipation, diarrhea
• Buildup of gas
• Rash, itching
• Chills
• Loss of appetite
• Pain, joint pain
• Fatigue, muscle weakness
• Swelling in the hands and feet