Clostran 9gm Sachetis used in the following:

• Hypercholesterolemia
• Hyperlipidemia
• Atherosclerosis prevention
• Coronary artery disease (CAD)
• Familial hypercholesterolemia
• Pruritus due to bile obstructionClostran 9gm Sachet

Clostran 9gm Sachet binds to bile acids within the intestines, creating complexes that are subsequently eliminated from the body. This prompts the liver to synthesize additional bile acids from cholesterol, decreasing cholesterol levels in the bloodstream. By reducing cholesterol, this medication assists in preventing conditions linked to high cholesterol, notably atherosclerosis and cardiovascular diseases. 

Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Clostran 9gm Sachete, reducing effectiveness by causing undesirable side effects. 

• Store at room temperature, between  20°C to 25°C
• Keep away from moisture, heat, and light.
• It should not be frozen.
• Keep away from children and pets.

Clostran 9gm Sachet is typically administered orally, which means it is taken by mouth. It comes in the form of a powder that can be mixed with liquids, such as water or juice, before being consumed. This oral formulation allows the medication to work in the gastrointestinal tract, where it binds to bile acids and helps lower cholesterol levels through its mechanism of action. This medication is not typically available in other forms, like injections or topical applications, as its intended mechanism of action is best achieved through oral administration.

Serious

• Allergic reactions
• Severe constipation or bowel obstruction
• Nutrient deficiencies
• Interactions with other medications
• Elevated triglyceride levels

Common

• Gastrointestinal discomfort
• Constipation
• Nausea
• Vomiting
• Diarrhea
• Indigestion

Inform your healthcare provider about all medications, supplements, allergies, and medical conditions; be cautious of potential nutrient deficiencies, particularly fat-soluble vitamins; discuss gastrointestinal disorders, liver problems, and allergies before use; monitor blood glucose levels if you have diabetes; maintain adequate fluid intake to prevent constipation; time other medications around Clostran 9gm Sachet intake to avoid interactions; attend regular check-ups for cholesterol monitoring; follow dietary recommendations; be aware of potential stool changes; consult your healthcare provider before using laxatives; take steps to protect dental health; adjust dosages for children and elderly individuals; understand long-term use implications; keep emergency information accessible. These precautions ensure the safe and effective use of this medication but always consult your healthcare provider for personalized advice.

1. KD Tripathi, Essentials of Medical Pharmacology, Hypolipidaemic Drugs and Plasma Expanders, 7th edition, 2013, 638.
2. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Drug therapy for Hypercholesterolemia and Dyslipidaemia, 12th edition, 2011, 899.
3. Neon Healthcare Limited, Electronic medicines compendium (EMC), [Revised on 04 May 2022] [ Accessed on 13th August 2023] ,https://www.medicines.org.uk/emc/product/10588/smpc#gref
4. Par Pharmaceutical, INC, US Food and Drug Administration, [Issued on Feb 2005] [Accessed on 14th August 2023], https://www.accessdata.fda.gov/drugsatfda_docs/anda/2005/077203Orig1s000.pdf