Cresemba 100mg capsule belongs to the class of antifungal medication. It is an antifungal medication used for the treatment of certain fungal infections. It contains the active ingredient Isavuconazole. Cresemba 100mg capsule is primarily used to treat invasive aspergillosis and invasive mucormycosis, which are serious and potentially life-threatening fungal infections that commonly affect individuals with weakened immune systems.

This medicine may cause severe liver problems. It is necessary to take liver function tests before starting the treatment. Inform your doctor prior to the therapy if you have abnormal heart rhythms or severe liver diseases. Stop taking this medicine if you develop any hypersensitive skin reactions. Do not stop taking medicine until your healthcare provider tells you to stop. Tell your healthcare provider about all the prescribed medicines you have recently taken because certain medications may affect how the Cresemba 100mg capsule works.

• Invasive aspergillosis
• Invasive mucormycosis

Cresemba 100mg capsule kills or stops the growth of the fungus by disrupting the biosynthesis of ergosterol (an important component of the fungal cell membrane).

Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Adenosine, reducing effectiveness by causing undesirable side effects.

• Store at room temperature, between 20°C to 25°C (68°F to 77°F).
• Keep away from moisture, heat, and light.
• It should not be frozen.
• Keep away from children and pets.

Take the Cresemba 100mg capsule in the dose and duration prescribed by your physician. Swallow the capsules with water as a whole. Do not chew, dissolve, open, or crush the capsule. Do not stop taking this medicine without medical advice from the doctor.

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.

Serious:

• Hypersensitive reactions (rash, swelling of lips, mouth, tongue, difficulty breathing)
• Blistering of mouth, skin, eyes, or genitals
• Liver problems (itchy skin, yellowing of eyes, flu-like symptoms, feeling very tired)
• kidney problems
• Respiratory problems

Common:

• Nausea, vomiting
• Diarrhea
• Headache
• Low potassium levels
• Shortness of breath, cough
• Swelling of arms, face, ankle, or legs
• Constipation
• Back pain
• Decreased appetite

Inform your doctor if you have an abnormal heart rhythm. your healthcare provider may ask you to take ECG before starting the treatment. If you experience any signs of an allergic reaction, such as rash, itching, swelling, or difficulty breathing, seek immediate medical attention. Pregnant or breastfeeding individuals should consult their healthcare provider before using Cresemba 100mg capsule, as the safety of the medication in these situations is not well-established. Close monitoring by a healthcare professional and adherence to prescribed guidelines are crucial for the safe and effective use of this capsule.

1. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Antifungal agents, 12th edition, 2011, 1582.
2. Astellas Pharma US, Inc, US, Inc, US Food and Drug Administration, [Revised on March 2015] [Accessed on 18th July 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/207500orig1s000lbl.pdf 
3. Basilea Pharmaceutica Deutschland GmbH, Electronic medicines compendium (emc), [Revised on Jan 2021] [Accessed on 18th July 2023], https://www.medicines.org.uk/emc/files/pil.5071.pdf