DAREIT R TABLET

Introduction:

Dareit R (600mg+100mg) Tablet consists of the active ingredients Darunavir ethanolate and Ritonavir. It is indicated for HIV infection. Antiviral drugs are beneficial in postponing the complications related to AIDS and improving the overall quality of life. 

This combination regimen belongs to the category of agents called protease inhibitors. It is prescribed to prevent replication of HIV to a maximum extent for as long as possible. Although this drug regimen reduces the risk of viral infection to a great extent, this is not a cure for HIV, and there is still a possibility of transmitting HIV to other people. 

Uses of Dareit R (600mg+100mg) Tablet:

• Treatment for children (more than 2 years of age), adolescents and adults infected with HIV, which causes AIDS

How Dareit R (600mg+100mg) Tablet works:

The protease enzymes of HIV are responsible for cleaving the precursor molecules to produce the final structural proteins of the virus. Dareit R (600mg+100mg) Tablet prevents this cleavage from taking place and controls the processing of viral proteins resulting in the production of immature and non-infectious viral particles.

Interaction with other drugs:

Inform your doctor about any medications you are taking or have taken before the treatment.

More Information:

Store protected from moisture at a temperature not exceeding 30˚C. Keep the container tightly closed after use.

References:

1. Janssen Pharmaceutical Companies, [Revised on Feb 2021] [Accessed on 6th Jul 2021], https://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/PREZISTA-pi.pdf
2. Dr. Reddy’s Laboratories (UK) Ltd, Electronic Medicines Compendium (EMC), [Revised on Apr 2021] [Accessed on 6th Jul 2021], https://www.medicines.org.uk/emc/files/pil.9979.pdf
3. Cipla Ltd., [Revised on 14th May 2020] [Accessed on 6th Jul 2021], https://www.ciplamed.com/print-product-pdf/35307
4. Accord Healthcare Limited, Electronic Medicines Compendium (EMC), [Revised on Nov 2020] [Accessed on 6th Jul 2021], https://www.medicines.org.uk/emc/files/pil.9279.pdf
5. KD Tripathi, Antiviral Drugs (Anti-retrovirus), Essentials of Medical Pharmacology, 8th Edition, 2019, 860-872.
6. Sharon Safrin, Antiviral Agents, Lange’s Basic & Clinical Pharmacology, 14th Edition, 2018, 863-894.

How to use Dareit R (600mg+100mg) Tablet:

Take this tablet with food. Swallow with a glass of water.

Safety Advice:

Pregnancy:

Inform your physician before starting this treatment if you are pregnant or think you might be pregnant. Your physician will determine the suitability and safe use of this medicine.

Breastfeeding: 

Breastfeeding might transmit HIV infection from mother to infant. Your physician might suggest you stop breastfeeding, depending on your condition.

Liver:

Inform your physician before starting this treatment if you have severe liver disease. Your physician will conduct liver function tests and prescribe accordingly.

Kidney:

Inform your physician before starting this treatment if you have kidney diseases. Your physician will prescribe accordingly.

Driving: 

Avoid driving or using machinery if you experience dizziness.

Allergies: 

Inform your physician if you experience allergic reactions to Darunavir, Ritonavir or its ingredients.

Others:

• Inform your physician before starting this treatment if you have heart problems, diabetes, symptoms of infection (fever, inflammation), hemophilia, musculoskeletal problem or bone diseases.
• Your physician will monitor your blood glucose and cholesterol levels frequently.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Serious:

• Liver problems
• Skin rash and itching
• Diabetes
• Unusual bleeding

Common:

• Weight gain
• Increased cholesterol and glucose levels in blood
• Diarrhea, vomiting, nausea, flatulence
• Stomach pain
• Headache
• Tiredness and dizziness
• Numbness or pain in hands or feet
• Loss of strength
• Sleeplessness
• Obesity, buffalo hump, breast enlargement
• Autoimmune disorders
• Flushing
• Throat pain
• Nerve damage
• Joint and back pain
• Anxiety
• Gout
• Increased urination
• Seizures
• Low platelet count
• Heavy periods
• Dehydration
• Loss of appetite
• Mouth ulcer
• Confusion, blurred vision
• High or low BP
• Acne