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Desferal 500mg Injection
Salt Composition : Deferoxamine
Manufacturer : NOVARTIS INDIA LTD
Origin of Medicine : Switzerland
Introduction to Desferal 500mg Injection
Desferal 500mg Injection contains an active component as deferoxamine. This medication is used to treat iron overload in the body. It belongs to a class of drugs called iron-chelating agents. Iron overload diseases are thalassemia, hemochromatosis, sickle cell disease, myelodysplastic syndromes, chronic transfusions and iron poisoning. Thalassemia is an inherited blood disorder causing abnormal hemoglobin production and anemia. Hemochromatosis is a hereditary condition with excessive iron absorption, leading to iron overload in organs. Sickle cell disease is a genetic disorder affecting red blood cell shape, causing pain and organ damage. Myelodysplastic syndromes are blood disorders affecting the bone marrow, leading to abnormal blood cell production. Chronic transfusions are required for severe anemia or blood disorders, leading to iron overload. Iron poisoning occurs when toxic amounts of iron are ingested and treated with Desferal 500mg Injection to eliminate excess iron from the body. Iron overload can occur in conditions such as thalassemia, hemochromatosis, or chronic transfusions, where excessive iron accumulates in organs and tissues, potentially causing damage.
By managing iron overload, Desferal 500mg Injection can improve the quality of life for individuals with conditions that cause iron accumulation. It may help reduce symptoms like fatigue, joint pain, and other complications associated with iron overload. Properly managing iron overload with this medication can help prolong the life expectancy of individuals with iron-related disorders by preventing severe organ damage and complications. Iron overload can lead to serious complications like liver disease, heart problems, and endocrine disorders. By reducing excess iron levels, it helps lower the risk of such complications.
Individuals with a known allergy to Desferal 500mg Injection or any of its components should not use this medication. Allergic reactions can range from mild skin rashes to severe anaphylactic reactions, which can be life-threatening. This is primarily excreted by the kidneys. Patients with significant kidney impairment may not be suitable candidates for Desferal 500mg Injection therapy or may require dosage adjustments and close monitoring. This medication has been associated with potential hearing and vision disturbances in some patients. Individuals with pre-existing hearing or vision problems should be cautious and may require more frequent monitoring. It is not suitable for treating iron deficiency anemia. It can exacerbate iron deficiency, so it should not be used in individuals with low iron levels. While this medication can be used in pediatric patients, careful monitoring and appropriate dosage adjustments based on weight and individual needs are essential.
Uses of Desferal 500mg Injection
Desferal 500mg Injection is used in the treatment of the following:
- Sickle cell disease
- Myelodysplastic syndromes
- Chronic transfusions
- Iron poisoning
Therapeutic Effects of Desferal 500mg Injection
The mechanism of action of Desferal 500mg Injection involves chelation, a process by which the drug binds to excess iron in the body. It forms stable complexes with free iron ions, particularly the trivalent iron, creating water-soluble compounds. These iron-deferoxamine complexes are then excreted primarily through the urine, effectively removing the excess iron from the bloodstream and tissues. By reducing iron levels, this medication helps to prevent iron-related oxidative damage to organs and tissues, mitigating the risk of organ dysfunction and other complications associated with iron overload conditions such as thalassemia, hemochromatosis, and chronic transfusions.
Interaction of Desferal 500mg Injection with other drugs
Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Desferal 500mg Injection, reducing effectiveness by causing undesirable side effects.
More Information about Desferal 500mg Injection
- Stored at controlled room temperature, between 20°C to 25°C (68°F to 77°F).
- Keep away from moisture, heat, and light.
- It should not be frozen.
- Keep away from children and pets.
How to consume Desferal 500mg Injection
Healthcare professionals typically administer Desferal 500mg Injection in a hospital or clinical setting. The injection may be given as an injection, depending on the treatment condition and the healthcare provider's instructions. Before administration, the healthcare professional will assess the patient's patient's medical history, current health status, and any known allergies or sensitivities.
Safety Advices for Desferal 500mg Injection
Desferal 500mg Injection use during pregnancy with caution and only used after consulting a healthcare provider.
The safety of Desferal 500mg Injection in breastfeeding has not been established, and there is a concern about the potential adverse effects it may have on the nursing baby.
Desferal 500mg Injection is generally safe to use in individuals with normal lung function. However, caution should be exercised in patients with pre-existing lung conditions or compromised respiratory function.
Desferal 500mg Injection is generally considered safe to use in individuals with normal liver function. However, caution should be exercised in patients with pre-existing liver conditions or liver impairment.
Both Desferal 500mg Injection and alcohol can potentially affect the liver. Combining the two may increase the risk of liver damage or worsen pre-existing liver conditions.
Common side effects of Desferal 500mg Injection may include dizziness, headache, and visual disturbances. If a person experiences any of these side effects while taking, it is essential to avoid driving or operating heavy machinery until they feel fully alert and able to concentrate.
Side Effects of Desferal 500mg Injection
Desferal 500mg Injection causes some side effects like all medications, although not everyone will experience them.
- Tightness of chest with wheezing or coughing and difficulty in breathing
- Allergic reactions (facial and throat swelling, feeling faint, rash)
- Decreased urine output
- Infections (fever accompanied by stomach pain and shortness of breath)
- Pain, swelling, redness, and itching at the injection site
- Reddish-brown color of urine
- Fever, feeling sick
- Slow growth in children under age three
Word of Advice
It is essential to inform your healthcare provider about any pre-existing medical conditions, allergies, or medications you are taking to avoid potential drug interactions or contraindications. Regular monitoring of iron levels, kidney function, and blood counts is crucial during treatment to ensure appropriate dosing and to detect any adverse effects promptly. If you experience any signs of allergic reactions, visual or hearing changes, difficulty breathing, or severe skin reactions, seek immediate medical attention. Take caution while driving or operating machinery, especially if you experience dizziness or headaches. Abrupt discontinuation of medication may lead to a rebound increase in iron levels, potentially exacerbating iron overload. Pregnant or breastfeeding individuals should discuss the potential risks with their healthcare provider before initiating treatment. Finally, adherence to the prescribed treatment plan and close communication with your healthcare team will help optimise the safety and effectiveness of Desferal 500mg Injection therapy.
Q 1. What are the common side effects of Desferal 500mg Injection?
Common side effects of Desferal 500mg Injection may include gastrointestinal disturbances (nausea, vomiting, diarrhea), injection site reactions, dizziness, and headache.
Q 2. Can Desferal 500mg Injection cause kidney problems?
Desferal 500mg Injection may affect kidney function in some patients, especially those with pre-existing kidney problems. Regular monitoring of kidney function is essential during treatment.
Q 3. Is Desferal 500mg Injection safe for children?
Desferal 500mg Injection is generally well-tolerated in children, but appropriate dosage and monitoring are crucial, especially in pediatric patients.
Q 4. How long is Desferal 500mg Injection treatment usually required?
The duration of Desferal 500mg Injection treatment depends on the severity of iron overload and the patient's response to therapy. Some individuals may require lifelong treatment, while others may need it for a specific period.
Q 5. Can Desferal 500mg Injection lead to iron deficiency?
While Desferal 500mg Injection is used to treat iron overload conditions, it may also lead to iron deficiency if not appropriately managed. Regular monitoring of iron levels is necessary to maintain a proper iron balance.
Q 6. Can Desferal 500mg Injection cause changes in vision or hearing?
Yes, Desferal 500mg Injection may cause visual and auditory disturbances, such as blurred vision or hearing loss, in some individuals.
- KD Tripathi, Essentials of Medical Pharmacology, Haematinics and Erythropoietin, 7th edition, 2013, 606.
- Goodman & Gilman's, The Pharmacological Basis of Therapeutics, Environmental toxicology: Carcinogenesis and heavy metals, 12th edition, 2011,1875.
- Novartis Pharmaceuticals UK Ltd, Electronic medicines compendium (EMC), [Revised on June 2020] [ Accessed on 28th July 2023], https://www.medicines.org.uk/emc/files/pil.3813.pdf
- Novartis, US Food and Drug Administration, [ Revised on Nov 2007] [Accessed on 28th July 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/016267s044lbl.pdf
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