Duralast 30mg Tablet is used to:

• Treat premature ejaculation: It helps men who ejaculate with minimal stimulation, before they wish to, and who have poor control over ejaculation.

• Improve control over ejaculation: It increases the time taken to ejaculate during sexual activity.

• Reduce distress linked to premature ejaculation: Better control can lessen the frustration and worry that PE can cause for the man and his partner.

Duralast 30mg Tablet is an on-demand medicine and is not intended for continuous daily use.

Duralast 30mg Tablet contains Dapoxetine, which blocks the reuptake of serotonin, a chemical messenger in the brain and nerves. This increases the action of serotonin in the pathways that control ejaculation.

Serotonin acts to delay ejaculation. By increasing its effect, Dapoxetine helps prolong the time taken to ejaculate and improves control. Dapoxetine is absorbed quickly, which is why it is taken 1 to 3 hours before sexual activity, and it leaves the body much faster than SSRIs used for depression.

Tell your doctor about all prescription medicines, over-the-counter medicines, supplements and herbal products you are taking before starting Duralast 30mg Tablet.

• Antidepressants and other serotonin-acting medicines: Do not use Duralast with SSRIs, SNRIs, tricyclic antidepressants, MAOIs, tramadol, triptans, linezolid, lithium, L-tryptophan or St. John’s wort. Combining them can cause serotonin syndrome, a serious reaction. Your doctor will advise on the gap needed between stopping one medicine and starting the other.

• Thioridazine: It should not be used with Duralast because the combination can seriously affect heart rhythm.

• PDE5 inhibitors (sildenafil, tadalafil, vardenafil): Duralast should not be used by men who are using these medicines for erectile dysfunction, as the combination can cause a drop in blood pressure on standing.

• Certain antifungal, antiviral and antibiotic medicines: Medicines such as ketoconazole, itraconazole and ritonavir must not be used with Duralast.

• Alpha-blockers and nitrates: These can lower blood pressure, so Duralast should be used with caution to avoid dizziness on standing.

• Aspirin, NSAIDs, blood thinners and antiplatelet medicines: These can increase the risk of bleeding when used with SSRIs.

• Recreational drugs: Do not use Duralast with drugs such as ketamine, MDMA or LSD, or with sedating drugs such as narcotics and benzodiazepines, as they can cause serious reactions or increase drowsiness and dizziness.

• Grapefruit juice: Avoid it for 24 hours before taking Duralast.

Do not start or stop any medicine without medical advice.

• Store Duralast 30mg Tablet at room temperature, below 25°C.

• Keep it away from moisture, heat and direct light.

• Keep it in the original strip until you are ready to take it.

• Keep it out of the reach of children and pets.

• Do not use the tablet after the expiry date printed on the pack.

• Follow the storage instructions printed on the product packaging.

Use Duralast 30mg Tablet exactly as prescribed by your doctor.

Take one 30 mg tablet only when sexual activity is expected, about 1 to 3 hours before. Do not take it every day, and do not take it more than once in 24 hours. Swallow the tablet whole with at least one full glass of water, as the tablet has a bitter taste. It can be taken with or without food.

• Do not increase the dose on your own. Only your doctor can decide whether a higher strength is suitable.

• Stay well hydrated and avoid alcohol around the time you take the tablet.

• Stand up slowly after sitting or lying down.

• If you feel light-headed, lie down or sit with your head between your knees until the feeling passes.

• Your doctor should review your treatment after the first four weeks, or after about six doses, and at least every six months after that.

• Do not use the tablet if you have not been diagnosed with premature ejaculation.

Common side effects of Duralast 30mg Tablet may include:

• Nausea

• Dizziness

• Headache

• Diarrhoea

• Difficulty sleeping

• Tiredness

• Dry mouth

• Blurred vision

• Increased sweating

• Flushing

• Stomach discomfort or indigestion

• Anxiety or irritability

• Sleepiness

Nausea and dizziness are the most common side effects. Side effects are more likely at higher doses and are usually mild.

Serious side effects

Seek medical attention if you develop:

• Fainting or loss of consciousness, which most often happens within the first 3 hours after a dose.

• Severe dizziness or light-headedness on standing, or a very slow, fast or irregular heartbeat.

• Low mood, thoughts of self-harm, severe anxiety, agitation or unusually elevated mood.

• A seizure.

• Signs of serotonin syndrome, such as agitation, confusion, fever, heavy sweating, tremor, muscle stiffness or a racing heartbeat.

• Eye pain, widened pupils or sudden changes in vision.

• Unusual bleeding or bruising.

• A serious allergic reaction, including rash, swelling of the face or throat or difficulty breathing.

• Take Duralast 30mg Tablet only when sexual activity is expected, 1 to 3 hours before.

• Do not take more than one tablet in 24 hours.

• Swallow the tablet whole with a full glass of water.

• Avoid alcohol, recreational drugs and grapefruit juice around the time you take it.

• Stay hydrated and stand up slowly to reduce the risk of dizziness and fainting.

• Tell your doctor about all your medicines, especially antidepressants, erectile dysfunction medicines, antifungals and blood thinners.

• Tell your doctor if you have heart problems, a history of fainting, low blood pressure, epilepsy, depression, bipolar disorder, a bleeding disorder, glaucoma, or kidney or liver problems.

• Tell your doctor if you also have erectile dysfunction before starting treatment.

• Report any mood changes or distressing thoughts to your doctor promptly.

• Keep your follow-up visits so your doctor can review whether the treatment is still right for you.