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Evaira 0.5mg Injection
Salt Composition : Eribulin
Manufacturer : ZYDUS CADILA
Origin of Medicine : India
1 Vial(s) Of 2ml
Introduction to Evaira 0.5mg Injection
Evaira 0.5mg Injection contains the active ingredient Eribulin. It is an antineoplastic drug belonging to the class of anti-microtubular agents. It is used to treat breast cancer in adults that have spread to other parts of the body (metastatic) and have already been treated with at least two other anti-cancer medications. Recently, Injection has been approved to treat liposarcoma, a rare type of cancer that occurs in the fat cells that cannot be removed by surgery or have spread to other organs in the body. It works by inhibiting the growth and spread of cancer cells.
Inform your physician if you have or ever had liver disease, fever or infection, kidney problems, heart problems, a family history of heart diseases, and electrolyte imbalance before starting the treatment with this Injection. Evaira 0.5mg Injection affects fertility in both men and women hence, it is important to use an effective birth control method. Do not take this Injection if you are allergic to eribulin or any other ingredients in it. It is unknown whether this Injection is safe and effective in children under 18 years of age.
The common side effects of Evaira 0.5mg Injection include hair loss, nausea, constipation, dehydration, sore throat, abdominal pain and swelling, inability to sleep, dizziness, decreased white blood cells and platelets count, chills, infection with fever, pain in the hands and feet. Consult your physician if you get any of these symptoms and continue for a long period.
Uses of Evaira 0.5mg Injection
Evaira 0.5mg is a prescription Injection, and it is used to treat
- Breast cancer that has spread to other body parts and has already received treatment with other anti-cancer medications.
- Liposarcoma that has spread to other organs or cannot be removed with surgery and treated with other anti-cancer medication.
Therapeutic Effects of Evaira 0.5mg Injection
Evaira 0.5mg Injection is a microtubule inhibitor that exerts its action by inhibiting the growth phase of microtubules in the cell cycle without affecting other stages. It acts by blocking rapid cell growth and disrupting the mitotic spindle, which is responsible for cell division. This leads to tumor cell death after prolonged mitotic blockage.
Interaction of Evaira 0.5mg Injection with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Evaira 0.5mg Injection and reduce effectiveness by causing undesirable side effects.
More Information about Evaira 0.5mg Injection
- Store Evaira 0.5mg Injection in the original package at room temperature (25°C). Do not freeze.
- Keep it out of reach from children and pets.
- It is important to get the dose at the scheduled time. If you missed the schedule, contact your doctor and reschedule the dose.
How to consume Evaira 0.5mg Injection
The Injection will be administered to you by a qualified healthcare professional in a hospital setting. This injection will be given intravenously into your vein over a period of 2 to 5 minutes. Do not self-administer this Injection. The dose of the injection will be decided by your doctor based on your disease condition and other factors. Evaira 0.5mg Injection is usually given on day 1 and day 8 of every 21-day cycle.
Safety Advices for Evaira 0.5mg Injection
Evaira 0.5mg Injection is unsafe when administered during pregnancy because it may cause serious birth defects in your baby. Consult your doctor if you are pregnant or planning for pregnancy during the treatment. This drug can cause infertility problems. It is advised to use effective contraception during the treatment with this injection and at least 2 weeks after the final dose.
It is unsafe to breastfeed during the treatment with this injection because it may cause harm to the baby. Please consult your doctor before breastfeeding.
It is unknown whether Evaira 0.5mg Injection can be administered to patients with lung problems. Consult your doctor if you have any lung diseases before starting the treatment.
It should be used cautiously in patients with liver disorders. Inform your physician if you have any liver problems before starting treatment with Evaira 0.5mg Injection.
It is unknown whether consuming alcohol interacts with Evaira 0.5mg Injection. Please consult your doctor for more advice.
It is unsafe to drive vehicles or operate heavy machinery after taking this Injection because Evaira 0.5mg contains a small amount of alcohol which may cause dizziness and impairs with your concentration.
Side Effects of Evaira 0.5mg Injection
Side effects are unwanted symptoms caused by Injections. Even though all drugs cause side effects, not everyone gets them.
- Alopecia (Hair loss)
- Nausea and Vomiting
- Liver function test abnormalities, altered level of sugar, bilirubin, phosphates, potassium, magnesium or calcium in the blood
- Anemia, Tiredness
- Weakness, numbness, and pain in hands and feet
- Decreased white blood cells and platelets
- Inability to sleep and dizziness
- Skin rash
- Prolonged QT interval
- Changes in heart rhythm
- Infection in blood
- High fever
- Inflammation in lungs, and pancreas
- Blood clots and internal bleeding
Word of Advice
Inform your physician if you are taking any other anti-cancer medications or heart medications. Since Evaira 0.5mg Injection can cause fertility problems in men and women. If you are a male and your partner still has reproductive potential it is necessary to use effective contraception during the treatment and at least for 14 weeks (3.5 months) after your final dose of Injection. Female patients are advised to use the contraception for 2 weeks after the last dose. Avoid getting pregnant and breastfeeding during the treatment. This Injection may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Your physician may advise you to do regular blood tests to monitor your disease condition and the effectiveness of the treatment.
Q 1. What is the most important information that I should know while taking Evaira 0.5mg Injection?
Evaira 0.5mg Injection can cause serious adverse effects such as low white blood cell count and numbness, tingling, and pain in the hands and feet. Inform your physician immediately if you face any of these symptoms.
Q 2. Does Evaira 0.5mg Injection cause infertility?
Yes, Evaira 0.5mg Injection causes infertility in men and women. It is necessary to use effective birth control methods during the treatment and for 2 weeks (females), 14 weeks (males) after the final dose of the injection.
Q 3. Is hair loss caused by Evaira 0.5mg Injection reversible?
Hair loss is a common side effect of Evaira 0.5mg Injection. It is reversible, but it depends totally on the severity of the hair loss and varies from person to person. Consult your doctor if you have severe hair loss.
Q 4. Do I have to follow any special dietary requirements while taking Evaira 0.5mg Injection?
It depends upon the severity of the disease condition. You can have a normal diet until or unless your physician tells you to follow any special food or diet chart. Check with your doctor if you have any nutrition concerns.
Q 5. What should I do if missed taking Evaira 0.5mg Injection?
It is important to get the Evaira 0.5mg injection at the right time. If in case you missed your appointment, contact your healthcare provider and schedule your dosing right away. Keep follow-ups on your next schedule.
Q 6. On what days should I receive Evaira 0.5mg Injection?
The dose is given on Day 1 and Day 8 in the 21-day chemotherapy cycle. Sometimes your doctor may delay your dosing day based on your disease severity and other factors.
Fact Box of Evaira 0.5mg Injection
Molecule name: Eribulin
Therapeutic class: Antineoplastics
Pharmacological class: Anti-microtubular
1. Breast cancer
- www.medicines.org.uk. (2023). Eribulin injection - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: https://www.medicines.org.uk/emc/product/4517/smpc [Accessed 17 Feb. 2023].
- HIGHLIGHTS OF PRESCRIBING INFORMATION - Eribulin Injection. (2016). [online] FDA. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/201532s015lbl.pdf [Accessed 17 Feb. 2023].
- Dybdal-Hargreaves, N.F., Risinger, A.L. and Mooberry, S.L. (2015). Eribulin Mesylate: Mechanism of Action of a Unique Microtubule-Targeting Agent. Clinical Cancer Research, [online] 21(11), pp.2445–2452. doi:https://doi.org/10.1158/1078-0432.ccr-14-3252[Accessed 17 Feb. 2023].
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