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GAZYVA 1000MG INJECTION_1
GAZYVA 1000MG INJECTION_2
GAZYVA 1000MG INJECTION_1
15% Off

Gazyva 1000mg Injection

Prescription Required

cold-chain

Salt Composition : Obinutuzumab

Manufacturer : ROCHE PRODUCTS INDIA PVT LTD

Origin of Medicine : Switzerland

MRP: â‚ą399305
Price : â‚ą339409.25
You Save : â‚ą59896 (15%)

1 Vial(s) Of 40ml

Prepaid Only. Non-Returnable

PAP Information :    Contact us for latest updates.

Patient Assistance Programs

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Introduction to Gazyva 1000mg Injection

Gazyva 1000mg injection contains the active substance Obinutuzumab. It is an antineoplastic drug that belongs to the class of medications called Anti-CD20 monoclonal antibodies. It is used in combination with other anticancer medicines to treat chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma (NHL)  in adults. It works by killing and stopping cancer cells from growing. 

Do not take this Gazyva 1000mg injection if you are allergic to obinutuzumab or any other ingredients of this medicine. Inform your physician if you have an active infection, or suffered from any infections, weak immune system, have or had heart problems, brain disorders, eye disorders, breathing problems, and liver diseases. Report to your physician if you face any symptoms of sudden difficulty in breathing, dizziness, diarrhea, cough, skin rash, chest pain, or fever after the administration of the injection.  

Inform your physician if you face any symptoms of memory loss, trouble speaking, difficulty walking, or problems with your eyesight during the treatment with Gazyva 1000mg injection because these may indicate rare and life-threatening side effects. This medicine is not recommended for children and young people under 18 years of age. Use an effective method of contraception while being treated with this injection.   Avoid pregnancy and breastfeeding during the treatment. 

Uses of Gazyva 1000mg Injection

  • Chronic lymphocytic leukemia (CLL)
  • Non-Hodgkin’s lymphoma (NHL)

Therapeutic Effects of Gazyva 1000mg Injection

Chronic lymphocytic leukemia (CLL) and Non-Hodgkin’s lymphoma (NHL) are types of cancer that affect a specific type of WBC called B-lymphocytes. The affected cells multiply too quickly and survive longer. Gazyva 1000mg injection binds to CD20 targets on the surface of the affected B-lymphocyte cells and causes them to die. When the injection is administered to the patient with other anticancer medicines, this slows down the progression time of the disease and works effectively by killing the abnormal cancer cells. 

Interaction of Gazyva 1000mg Injection with other drugs

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, recent vaccinations, nutritional and vitamin supplements, and herbal products. Certain medications may interact with Gazyva 1000mg injection and reduce its effectiveness by causing undesirable side effects. 

More Information about Gazyva 1000mg Injection

  • Store Gazyva 1000mg injection in the refrigerator (2°C to 8°C)
  • Do not freeze
  • keep the injection away from the reach of children and pets.
  • If you have missed any dosing appointments, inform your doctor and schedule immediately.

How to consume Gazyva 1000mg Injection

It will be given to you by a doctor or nurse in a hospital or clinic setting trained in cancer chemotherapy. It is given as an intravenous infusion drip (into your vein) for several hours. Do not self-administer the injection. Your doctor will decide the dose and duration of the treatment based on your disease severity, body weight, and other factors. Your doctor will give you certain medications to lessen the chance of getting side effects from the Gazyva 1000mg injection treatment.  

Safety Advices for Gazyva 1000mg Injection

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Pregnancy

  

Gazyva 1000mg injection is unsafe to administer in pregnant women because it may affect the fetus. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant. Using an effective birth control method during the treatment and for 18 months after your last dose is necessary.  

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Breast Feeding

  

Breastfeeding is not recommended in patients taking Gazyva 1000mg injection because the medicine passes into the breast milk in small amounts and may harm your baby. 

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Lungs

  

It is unknown whether Gazyva 1000mg injection can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.

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Liver

  

Gazyva 1000mg injection is safe to use in patients with liver diseases. No dose adjustments are necessary. Inform your physician if you have any liver problems before initiating the therapy. 

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Alcohol

  

It is unknown whether consuming alcohol is safe during the treatment with Gazyva 1000mg injection. Inform your doctor if you are a chronic drinker. 

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Driving

  

Gazyva 1000mg injection does not affect the ability to drive. If you feel tired or dizzy after taking this medicine or if you get any infusion-related side effects, do not drive and consult your doctor for more advice.

Side Effects of Gazyva 1000mg Injection

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. 

 Common 

  • Hair fall
  • Constipation, diarrhea
  • Anemia
  • Decreased WBC and platelets
  • Infection
  • Muscle pain
  • Headache, insomnia
  • Urinary tract infections
  • Cough
  • Fever, tiredness
  • Decreased appetite 

Serious 

  • Bleeding in the stomach
  • Anemia
  • Hypersensitivity reactions
  • Brain problems
  • Severe infections

Word of Advice

Gazyva 1000mg injection may interfere with vaccines, inform your physician before taking any flu shot or any other vaccines. This injection may cause severe birth defects if taken during pregnancy. Female patients with reproductive potential should use effective contraception during the treatment. Do not breastfeed during treatment and for 6 months after your last dose. Inform your doctor if you have a history of hepatitis B infection. This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often. Your doctor may advise you to take certain tests to check for the effectiveness of the therapy. 

FAQs

Q 1. What are the infusion reactions that might happen during Gazyva 1000mg injection?

Allergic reactions like itching, swelling in your face or hands, tingling in mouth or throat, chest tightness, difficulty in breathing, fever, chills, cough, sore throat, body aches, unusual bleeding, bruising, or weakness should be informed to your doctor immediately.

Q 2. How long should I have to take Gazyva 1000mg injection?

Gazyva 1000mg injection is given as a cycle therapy. Your doctor will decide the dose and duration of the therapy based on your disease severity and condition.

Q 3. What is the infusion time of Gazyva 1000mg injection?

Generally, Gazyva 1000mg injection is given as an infusion intravenously (into your vein). The infusion should be not given for more than 4 hours. Your doctor will decide the duration of the infusion based on your disease condition, and other factors.

Q 4. Is Gazyva 1000mg injection better than rituximab?

The anti-CD20 monoclonal antibodies rituximab and Gazyva 1000mg injection differ in their mechanisms of action, with this injection evoking greater direct B cell death. Your doctor will decide the best therapy that works for you based on the condition and severity of the disease.

Q 5. Can Gazyva 1000mg injection cause shortness of breath?

Gazyva 1000mg injection can cause infusion-related reactions like shortness of breath. If you face any symptoms inform your doctor immediately and seek medical advice.

Fact Box of Gazyva 1000mg Injection

Molecule name: Obinutuzumab 

Therapeutic class: Antineoplastics

Pharmacological class: Anti-CD20 monoclonal antibodies

Indications: 

1. Chronic lymphocytic leukemia (CLL)

2. Non-Hodgkin’s lymphoma (NHL) 

References

  1. Gazyvaro 1,000 mg concentrate for solution for infusion - Patient Information Leaflet (PIL) - (emc). www.medicines.org.uk. [Revised 2022] [cited 2023 Apr 25]. Available from: https://www.medicines.org.uk/emc/product/3279/pil
  2. GAZYVA-obinutuzumab injection. [revised on 2017] [cited 2023 Apr 25]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/125486s017s018lbl.pdf
  3. Jenny O’Nions, William Townsend et al; The role of obinutuzumab in the management of follicular lymphoma; Future Oncology; Published on Nov 2019; Accessed on 25/04/2023; https://pubmed.ncbi.nlm.nih.gov/31538821/

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