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Glenza 40mg Capsule
Salt Composition : Enzalutamide
Manufacturer : GLENMARK PHARMACEUTICALS LTD
Origin of Medicine : India
28 Capsule(s) In A Strip
Introduction to Glenza 40mg Capsule
Glenza 40mg capsule contains the active ingredient Enzalutamide. It is an antineoplastic drug that belongs to the category of medicines known as androgen receptor inhibitors. This medication is used in the treatment of advanced prostate cancer in patients who do not respond to surgical or hormonal treatments.
It is not recommended to take enzalutamide tablets if you are allergic to enzalutamide or any of its ingredients. During the enzalutamide treatment, your doctor may periodically monitor for Prostate-specific antigen (PSA) tests. This blood test measures the level of PSA, a protein produced by the prostate gland that can be elevated in men with prostate cancer. PSA levels can help monitor the progression of the disease and the response to treatment. Other tests also include liver function tests and complete blood count(CBC) to prevent serious complications.
This medicine can cause seizures, so patients with a history of seizures should use caution when taking this medication. Avoid grapefruit and grapefruit juice while taking Enzalutamide, as it can increase the levels of the medication in the body. This drug is not recommended during pregnancy as it causes harm to the unborn baby, and it also causes fertility issues, inform your doctor about any fertility concern you may have before starting treatment with this medicine. Before beginning this treatment, tell your healthcare provider if you are pregnant or planning to have a baby. It is advised for both men and women to follow proper contraceptive methods during and for 3 months after the last dose of Enzalutamide.
Uses of Glenza 40mg Capsule
- Advanced prostate cancer
Therapeutic Effects of Glenza 40mg Capsule
It works by inhibiting the active form of testosterone, called dihydrotestosterone. It selectively blocks the androgen receptors and disrupts the translocation of signals from the receptor to the cell. Thus, the androgen hormone does not bind to the androgen receptors and these androgen receptors do not interact with DNA. This blocks the functioning of cancer cells and reduces its multiplication.
Interaction of Glenza 40mg Capsule with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Glenza 40mg capsule and reduce effectiveness by causing undesirable side effects.
More Information about Glenza 40mg Capsule
- Store Glenza 40mg capsule in the original package at room temperature (20°C to 25°C).
- Keep it out of reach from children and pets.
How to consume Glenza 40mg Capsule
Your doctor will decide the dose and duration of enzalutamide based on the disease condition and other factors. Always take this medicine as prescribed by your doctor. The standard dose for Enzalutamide is 160 mg taken once daily, with or without food. Do not chew, crush, or break the tablet. Swallow the whole tablet with water. If you forgot to take the tablet, simply take your next dose at the scheduled time. Do not take a double dose to make up for a forgotten dose.
Safety Advices for Glenza 40mg Capsule
Glenza 40mg capsule is not recommended for pregnant women as they may cause fetal harm. Consult your doctor if you are pregnant or planning for pregnancy during the treatment.
It is not known if Enzalutamide passes into your breast milk or if it will affect your baby or your breast milk. Talk to your doctor about the best way to feed your baby if you receive this drug.
It is not known whether Glenza 40mg capsule can be prescribed to patients with lung problems. Consult your doctor if you have any lung diseases before starting the treatment.
Inform your doctor if you have any liver disorders before taking Glenza 40mg capsule. Regular monitoring of liver function tests is recommended.
It is unknown whether consuming alcohol interacts with Glenza 40mg capsule. Please consult your doctor for more advice.
Glenza 40mg capsule may cause drowsiness which can affect the patient’s ability to drive or use machines. Consult your doctor before you resume driving.
Side Effects of Glenza 40mg Capsule
Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.
- Posterior reversible encephalopathy syndrome
- Heart disease
- Falls and fractures
- Back pain
- Decreased appetite
- High BP
- Dry skin
- Enlarged breasts in men
- Inability to concentrate
Word of Advice
Glenza 40mg capsule causes skin dryness so it is advised to use an effective moisturiser for your skin. Ensure that you stay hydrated and maintain a balanced diet. Store the drug in the original package at room temperature (25°C). Keep it out of reach from children and pets. It is important to get the dose at the scheduled time. If you missed the schedule, contact your doctor and reschedule the dose. Avoid driving or operating heavy machines if you experience dizziness, nausea or tiredness while on treatment with Enzalutamide.
Q 1. What tests are essential before starting treatment with Glenza 40mg capsule?
Before starting treatment with Glenza 40mg capsule, your healthcare provider will recommend tests for Prostate-specific antigen (PSA) tests. This blood test measures the level of PSA, a protein produced by the prostate gland that can be elevated in men with prostate cancer. PSA levels can help monitor the progression of the disease and the response to treatment. Other tests also include liver function tests and complete blood count(CBC).
Q 2. What should you do if you missed a dose of Glenza 40mg capsule?
If you missed taking a dose of Glenza 40mg capsule, skip this dose. Do not take two tablets to make up for the missed dose. Report to your healthcare provider right away if you missed taking more than two doses of Enzalutamide.
Q 3. Who should not take Glenza 40mg capsule?
Glenza 40mg capsule is not recommended for people who are allergic to enzalutamide, and its ingredients. Also, women who are pregnant or breastfeeding should avoid taking it, because enzalutamide can harm an unborn baby or pass into breast milk.
Q 4. Can you smoke while on treatment with Glenza 40mg capsule?
It is not recommended to smoke cigarettes while on treatment with Glenza 40mg capsule as smoking can reduce the concentration of Enzalutamide in the body.
Q 5. How do you know if you have overdosed on Glenza 40mg capsule?
Watch out for symptoms like fatigue, tiredness, nausea, vomiting, severe headache and seek immediate medical attention from a nearby healthcare facility.
Fact Box of Glenza 40mg Capsule
Molecule name: Enzalutamide
Therapeutic class: Antineoplastics
Pharmacological class: Androgen receptor inhibitors
1.Advanced prostate cancer
- Astellas Pharma Ltd, [Revised on Oct 2020] [Accessed on 8th Apr 2021], https://www.astellas.us/docs/12a005-enz-wpi.pdf
- Astellas Pharma Europe B.V, Electronic Medicines Compendium (EMC), [Revised on May 2021] [Accessed on 12th Nov 2021], https://www.medicines.org.uk/emc/files/pil.10318.pdf
- Martín LázaroQuintela et al., Enzalutamide: a new prostate cancer targeted therapy against the androgen receptor, Cancer Treatment Reviews. Mar 2015; 41(3): 247-253 [Accessed on 8th Apr 2021],https://ruc.udc.es/dspace/bitstream/handle/2183/21551/Lzro_Enzlutamide.pdf?sequence=3&isAllowed=y
- Marina D. Kaymakcalan and Christy S. Harris, Prostate Cancer, Applied Therapeutics, The Clinical Use Of Drugs, 11th Edition, 2018, 2083-2100.
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