Manufacturer : DR REDDY'S LABORATORIES LTDOrigin of Medicine : India
You Save:₹7957.05 (74%)
5 CAPSULE(s) IN A BOTTLE
Glioz 100mg Capsule consists of the active substance Temozolomide. It is prescribed to treat adults with brain cancer. It is the standard drug used in combination with radiotherapy to treat patients with glioblastoma multiforme and anaplastic astrocytoma. Glioblastoma and anaplastic astrocytoma are the most common and aggressive brain cancers with low chances of survival. Anaplastic astrocytoma is treated with Glioz 100mg Capsule or radiotherapy after biopsy, whereas Glioblastoma multiforme is treated with a combination of radiotherapy and Glioz 100mg Capsule and then Glioz 100mg Capsule is continued as maintenance therapy.
Uses of Glioz 100mg Capsule:
Concomitant and maintenance treatment along with radiotherapy for treatment of newly diagnosed glioblastoma multiforme.
Treatment of refractory anaplastic astrocytoma in patients who experienced disease progression after being treated with nitrosurea and procarbazine.
How Glioz 100mg Capsule Works:
Glioz 100mg Capsule works by following a process called alkylation. After administration, Glioz 100mg Capsule gets converted into its active form called metabolite 5-(3-methyltriazen-1-yl) imidazole-4-carboxamide (MTIC). This metabolite reacts with water to form methyl diazonium ions. The methyl group from methyl diazonium ions transfer into the DNA and breaks the DNA strands that results in cell cycle arrest and cell death.
Interaction with other drugs:
Inform your doctor about any medications you are taking or have taken before the treatment.
Store the medicines in a locked cupboard, away from sight and reach of children. Do not store above 25˚C.
Neha Singh et al., Mechanisms of temozolomide resistance in glioblastoma - a comprehensive review, Cancer Drug Resist 2021;4:17-43, [Accessed on 28th Apr 2021], https://cdrjournal.com/article/view/3779
Use as directed by your physician. Your physician will prescribe an adequate dose according to your height and weight. Swallow the Capsule whole with a glass of water, on an empty stomach. Do not crush or chew the Capsule and avoid contact of the Capsule with your skin.
Glioz 100mg Capsule is harmful to the fetus. Inform your physician before taking Glioz 100mg Capsule if you are pregnant or think you might be pregnant.
Glioz 100mg Capsule passes through breast milk. Consult your physician for advice before breastfeeding.
Inform your physician before taking Glioz 100mg Capsule if you have liver problems.
Inform your physician before taking Glioz 100mg Capsule if you have kidney problems.
Avoid driving or doing things that require concentration if you experience any side effects.
Inform your physician right away if you have allergic reactions to Glioz 100mg Capsule or its ingredients
Consult your physician if you have blood clotting problems, low levels of RBC, WBC or platelets. Make sure that your physician monitors your WBC and platelet counts regularly.
Inform your physician if you have a history of Hepatitis B infection.
Glioz 100mg Capsule can cause birth defects. Exercise effective birth control measures during treatment with Glioz 100mg Capsule.
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Secondary cancer like myelodysplastic syndrome and myeloid leukemia.
Difficulty concentrating, changes in mental status and alertness
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