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Hepcinat 400mg Tablet

Prescription Required

Salt Composition : Sofosbuvir

Manufacturer : NATCO PHARMA LTD

Origin of Medicine : India

MRP: 15000
Price :3621
You Save :11379 (76%)

28 Tablet(s) In A Bottle

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Introduction to Hepcinat 400mg Tablet

Hepcinat 400mg Tablet contains the active component as Sofosbuvir. It is a direct-acting antiviral medication used to treat hepatitis C virus (HCV) infection. This medication is often combined with other antiviral drugs to form a regimen that can effectively eliminate HCV from the body. Hepcinat 400mg Tablet has significantly shortened the duration of HCV treatment compared to older therapies. It is effective against multiple genotypes of the hepatitis C virus. This broad-spectrum activity makes it a versatile treatment option that can be used for a wide range of patients infected with different HCV genotypes. 

Patients have generally well-tolerated with this medication, with few serious side effects reported. Hepcinat 400mg Tablet should not be used in individuals with known hypersensitivity or allergic reactions to it or its components. This medication is primarily eliminated through the kidneys. Therefore, individuals with severe renal impairment may require dosage adjustments. It is not approved for use in children under the age of 18.

Uses of Hepcinat 400mg Tablet

  • Treatment of hepatitis C virus (HCV) infection

Therapeutic Effects of Hepcinat 400mg Tablet

Hepcinat 400mg Tablet, a direct-acting antiviral medication, exerts a potent therapeutic effect in treating hepatitis C virus (HCV) infections. This medication disrupts the virus's ability to replicate and proliferate within the body by inhibiting the RNA polymerase enzyme necessary for HCV replication. When combined with other antiviral drugs, this targeted action leads to high cure rates, improved treatment outcomes, and shorter treatment durations.

Interaction of Hepcinat 400mg Tablet with other drugs

Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Hepcinat 400mg Tablet, reducing effectiveness by causing undesirable side effects.

More Information about Hepcinat 400mg Tablet

  • Stored at controlled room temperature, between 20°C to 25°C (68°F to 77°F).
  • Keep away from moisture, heat, and light.
  • It should not be frozen.
  • Keep away from children and pets.

How to consume Hepcinat 400mg Tablet

Hepcinat 400mg Tablet is typically prescribed with other antiviral medications for treating hepatitis C (HCV) infection. This medication is usually taken orally once a day, with or without food. It is recommended to complete the full course of treatment as prescribed, even if symptoms improve, to ensure the best chance of achieving a sustained virologic response (SVR) and curing the HCV infection.

Safety Advices for Hepcinat 400mg Tablet

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The safety of Hepcinat 400mg Tablet use during pregnancy has not been established. If you are pregnant or planning to become pregnant, discussing the potential risks and benefits with your healthcare professional is essential.

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Breast Feeding


Limited data are available on the safety of Hepcinat 400mg Tablet during breastfeeding, and it is important to discuss the potential risks and benefits with a healthcare professional.

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Suppose you have a pre-existing lung condition or are concerned about the safety of the Hepcinat 400mg Tablet in your lungs. Consulting with your healthcare provider for personalized advice is recommended in that case.

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If you have a liver condition or are concerned about the safety of Hepcinat 400mg Tablet, it is recommended to consult your healthcare provider for personalized advice.

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It is generally advisable to avoid consuming alcohol while taking Hepcinat 400mg Tablet. Alcohol can impair the body's immune system, making it less effective in fighting infections.

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After using Hepcinat 400mg Tablet, people may experience side effects, including dizziness, drowsiness, or fatigue. In that case, avoid driving or operating heavy machinery.

Side Effects of Hepcinat 400mg Tablet

Hepcinat 400mg Tablet causes some side effects like all medications, although not everyone will experience them. 


  • Allergic reactions that affect skin and breathing
  • Hepatitis B infection reactivation
  • Bradycardia (slow heartbeat)


  • Fatigue
  • Headache
  • Nausea
  • Insomnia
  • Diarrhea
  • Itching
  • Decreased appetite
  • Rash or skin reactions

Word of Advice

Before starting treatment, inform your healthcare provider if you have a history of hepatitis B, your liver function, HBV DNA levels (an indicator of hepatitis B infection in the blood) will closely monitor during treatment. Be aware of the risk of serious bradycardia when Hepcinat 400mg Tablet is combined with Amiodarone, and inform your healthcare provider if you are taking this medication. Any signs of allergic reactions, such as difficulty breathing or swelling, should be reported immediately. Pregnant and breastfeeding individuals should discuss the potential risks and benefits with their healthcare provider. Adhere to the prescribed treatment regimen and attend regular check-ups to monitor treatment response.


Q 1. Can Hepcinat 400mg Tablet be used as a single therapy for hepatitis C?

No, Hepcinat 400mg Tablet is not recommended as a monotherapy for hepatitis C. It is typically used in combination with other antiviral medications. The specific combination therapy will depend on factors such as the HCV genotype, previous treatment history, and the presence of liver cirrhosis.

Q 2. Can Hepcinat 400mg Tablet prevent hepatitis C transmission?

Hepcinat 400mg Tablet primarily treats individuals already infected with hepatitis C. While it can cure the infection and reduce the viral load, it does not provide direct protection against acquiring hepatitis C or prevent transmission to others. Prevention of hepatitis C transmission involves practicing safe behaviors such as using barrier methods during sexual activity, avoiding sharing needles or other drug paraphernalia, and taking precautions to prevent blood-to-blood contact.

Q 3. Can Hepcinat 400mg Tablet be used in patients with liver cirrhosis?

Yes, Hepcinat 400mg Tablet can be used in patients with liver cirrhosis. It has shown efficacy and safety in patients with compensated and decompensated liver cirrhosis. However, careful monitoring and individualized treatment plans may be required for patients with advanced liver disease.

Q 4. Can Hepcinat 400mg Tablet be used in elderly patients?

Yes, Hepcinat 400mg Tablet can be used in elderly patients. Age alone is not a contraindication for its use. However, elderly patients may have a higher likelihood of comorbidities and may be taking multiple medications, which can increase the risk of drug interactions.

Q 5. Can Hepcinat 400mg Tablet be used in patients with HIV?

Yes, Hepcinat 400mg Tablet can be used in patients who are co-infected with both hepatitis C virus (HCV) and HIV. However, the choice may depend on the specific antiretroviral therapy used to treat HIV. Some antiretroviral medications can interact with it, potentially affecting the levels of both drugs in the body. It is crucial to work closely with healthcare providers to cure HCV and HIV co-infection to ensure optimal treatment outcomes.

Q 6. What Are the side effects of Hepcinat 400mg Tablet?

Common side effects may include fatigue, headache, nausea, insomnia, diarrhea, itching, decreased appetite, and rash or skin reactions. Serious side effects are rare, including hepatitis B reactivation in co-infected individuals, serious bradycardia when combined with Amiodarone, and allergic reactions.

Fact Box of Hepcinat 400mg Tablet

Molecule name: Sofosbuvir

Therapeutic class: Antiviral Agent

Pharmacological class: Nucleotide analog inhibitor

Indications: Hepatitis C virus (HCV) infection


  1. Gilead Sciences Ltd, Electronic medicines compendium (EMC), [Revised on 15 Nov 2021], [Accessed on 2nd June 2023],
  2. Gilead Sciences Ltd, US Food and Drug Administration, [Revised on August 2015],[Accessed on 1st June 2023],


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