IBRUNAT 140MG CAPSULE
IBRUTINIB
Manufacturer : NATCO PHARMA LTDOrigin of Medicine : IndiaIntroduction:
Ibrunat 140mg Capsule consists of the active ingredient Ibrutinib. It is indicated to treat blood cancers such as mantle cell lymphoma (MCL), chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (CLL), Waldenstrom’s macroglobulinemia, and Marginal zone lymphoma (MZL). These are cancers of the white blood cells called lymphocytes that are part of the immune system. They differ from each other by the location where cancer occurs, type of lymphocytes affected, and certain other factors.
Ibrunat 140mg Capsule is also used to treat chronic graft versus host disease (cGVHD) after the failure of systemic therapy. During allogeneic stem cell transplantation, the patient receives stem cells from the donor. GVHD occurs when donor cells view the patient’s cells as foreign and attack them. Before taking this medicine, you need to talk with your physician if you have bleeding problems, infection, liver problems, heart problems, or intolerance to some sugars. This medication is not recommended for adolescents and children.
It is vital to let the physician know if you have recently had or are about to have any surgical procedure. Your physician may stop Ibrunat 140mg Capsule for any planned surgical or medical procedure. Use effective birth control during the treatment and for at least one month after the final dose. Avoid having grapefruit or oranges in any form during this treatment; they may raise the amount of drug in the blood. Drink plenty of fluid to prevent dehydration. Inform your physician if you have diarrhea that does not go away.
Uses of Ibrunat 140mg Capsule:
Ibrunat 140mg Capsule is used in the treatment of:
- Mantle cell lymphoma
- Chronic lymphocytic leukemia
- Small lymphocytic lymphoma
- Waldenstrom’s macroglobulinemia
- Chronic graft vs. host disease after failure of systemic therapy
How Ibrunat 140mg Capsule works:
Ibrunat 140mg Capsule blocks the protein called Bruton’s tyrosine kinase that helps these cancer cells grow and survive. This stops the growth and worsening of cancer.
Interaction with other drugs:
Inform your doctor about any medications you are taking or have taken before the treatment.
More Information:
Store the capsules in the original packaging at room temperature (20-25°C).
References:
- Janssen-Cilag International Ltd, Electronic Medicines Compendium (EMC), [Revised on Dec 2021] [Accessed on 29th June 2022], https://www.medicines.org.uk/emc/files/pil.10040.pdf
- 2. Janssen Biotech, Inc, US Food and Drug Administration, [Revised on May 2022] [Accessed on 29th June 2022], https://www.imbruvica.com/files/prescribing-information.pdf
- H.G. Watson, J.I.O. Craig, L.M. Manson, Blood disease, Davidson’s Principles and Practice of Medicine, 22nd Edition, 2014, 989-1056.
- Sapna Parmar, Khilna Patel, Javier Pinilla-Ibarz, Ibrutinib (Imbruvica): A Novel Targeted Therapy for Chronic Lymphocytic Leukemia, Drug Forecast, Published on July 2014; Accessed on 29/06/2022; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103574/pdf/ptj3907483.pdf
How to use Ibrunat 140mg Capsule:
Consume this medicine at the same time each day. Do not consume grapefruit or orange in any form during the treatment. Drink plenty of fluid to prevent dehydration.
Safety Advice:
Pregnancy:
This medicine can harm the unborn baby. Do not take Ibrunat 140mg Capsule unless your physician instructed you to take it. Inform your physician before starting this treatment if you are pregnant or think you might be pregnant.
Breastfeeding:
Do not breastfeed during the treatment and for at least one week after the last dose. Consult your physician for risks and benefits.
Liver:
Inform your physician before starting this treatment if you have liver problems, including hepatitis B infection. This medicine could cause the reactivation of the hepatitis B virus, which makes the condition fatal.
Kidney:
Inform your physician before starting this treatment if you have kidney diseases. Your physician will monitor your kidney functions regularly.
Driving:
Ibrunat 140mg Capsule may cause dizziness or tiredness. Avoid driving or operating machines if you feel dizzy or tired.
Others:
Inform your physician if you:
- Have had recent surgery or plan to have surgery.
- Have bleeding problems, heart problems, infection, or intolerant to some sugars.
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. The Ibrunat 140 mg side effects are:
Serious:
- Bleeding problems
- Infections
- Decrease in blood cell counts
- Heart problems
- High BP
- Secondary cancer
- Tumor lysis syndrome
- Severe allergic reactions
Common:
- Nausea, vomiting, diarrhea
- Tiredness
- Muscle and bone pain
- Rash and bruising
- Mouth sores
- Pneumonia
- Fever, chills
- Breathlessness
- Constipation
- Dizziness
- Body pain
- Swollen ankles and feet
- Increased creatinine levels in blood
- Heavier periods and blood in urine
- Blurred vision
- Weakness and numbness

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