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Ibrunat 140mg Capsule
Salt Composition : Ibrutinib
Manufacturer : NATCO PHARMA LTD
Origin of Medicine : India
30 Capsule(s) In A Bottle
Introduction to Ibrunat 140mg Capsule
Ibrunat 140mg Capsule consists of the active ingredient Ibrutinib. It is indicated to treat blood cancers such as mantle cell lymphoma (MCL), chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (CLL), Waldenstrom’s macroglobulinemia, and Marginal zone lymphoma (MZL). These are cancers of the white blood cells called lymphocytes that are part of the immune system. They differ from each other by the location where cancer occurs, type of lymphocytes affected, and certain other factors
Ibrunat 140mg Capsule is also used to treat chronic graft versus host disease (cGvHD ) after the failure of systemic therapy. During allogeneic stem cell transplantation, the patient receives stem cells from the donor. GvHD occurs when donor cells view the patient’s cells as foreign and attack them. Before taking Ibrutinib Capsule, you need to talk with your physician if you have bleeding problems, infection, liver problems, heart problems, or intolerance to some sugars. This medication is not recommended for adolescents and children.
It is vital to let the physician know if you have recently had or are about to have any surgical procedure. Your physician may stop Ibrunat 140mg Capsule for any planned surgical or medical procedure. Use effective birth control during the treatment and for at least one month after the final dose. Avoid having grapefruit or oranges in any form during this treatment; they may raise the amount of drug in the blood. Drink plenty of fluid to prevent dehydration. Inform your physician if you have diarrhea that does not go away.
Uses of Ibrunat 140mg Capsule
Ibrunat 140mg Capsule is used in the treatment of
- Mantle cell lymphoma
- Chronic lymphocytic leukemia (Blood cancer)
- Small lymphocytic lymphoma
- Waldenstrom’s macroglobulinemia
- Chronic graft vs. host disease after failure of systemic therapy
Therapeutic Effects of Ibrunat 140mg Capsule
The mechanism of action of Ibrunat 140mg involves blocking a specific protein called Bruton's tyrosine kinase (BTK) which plays a key role in the survival and growth of cancer cells. By inhibiting BTK, Ibrunat 140mg prevents the cancer cells from receiving the signals they need to grow and divide, leading to their eventual death.
Interaction of Ibrunat 140mg Capsule with other drugs
Inform your healthcare professional about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. Certain medications interacting with Ibrunat 140mg , may reduce effectiveness by causing undesirable side effects.
More Information about Ibrunat 140mg Capsule
- Store the capsules in the original packaging at room temperature (20-25°C).
How to consume Ibrunat 140mg Capsule
Consume Ibrunat 140mg at the same time each day. While taking Ibrunat 140mg, do not consume grapefruit or orange in any form during the treatment. Drink plenty of fluid to prevent dehydration.
Safety Advices for Ibrunat 140mg Capsule
This medicine can harm the unborn baby. Do not take Ibrunat 140mg Capsule unless your physician instructs you to take it. Inform your physician before starting this treatment if you are pregnant or think you might be pregnant.
Do not breastfeed while you are under Ibrunat 140mg capsule and for at least one week after the last dose. Consult your physician for risks and benefits.
Ibrunat 140mg capsule may cause interstitial lung disease. So if you have any respiratory disorder, inform your doctor before starting the treatment.
Inform your physician before starting this treatment if you have liver problems, including hepatitis B infection. Ibrunat 140mg capsule could cause the reactivation of the hepatitis B virus, which makes the condition fatal.
It is unknown whether it is safe to consume alcohol with the Ibrutinib capsule. Please consult your doctor.
Ibrunat 140mg capsule may cause dizziness or tiredness. Avoid driving or operating machines if you feel dizzy or tired.
Side Effects of Ibrunat 140mg Capsule
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
- Bleeding problems
- Decrease in blood cell counts
- Heart problems
- High BP
- Secondary cancer
- Tumor lysis syndrome
- Severe allergic reactions
- Nausea, vomiting, diarrhea
- Muscle and bone pain
- Rash and bruising
- Mouth sores
- Fever, chills
- Body pain
- Swollen ankles and feet
- Increased creatinine levels in blood
- Heavier periods and blood in urine
- Blurred vision
- Weakness and numbness
Word of Advice
Contact your doctor immediately if you experience bleeding, infection, shortness of breath, or chest discomfort. Report to your doctor if you have had a history of heart failure or hepatitis infection. It is not recommended to take this medicine before or after surgery as it causes a delay in wound healing. Discuss effective contraceptive options with your healthcare provider and use them during treatment and for a month after the last dose of Ibrunat 140mg .
Q 1. Can I take Ibrunat 140mg to prevent getting cancer in the future?
Ibrunat 140mg is not approved for use as a cancer prevention medication, and its long-term effects on healthy individuals are not fully understood. If you are concerned about your risk of developing cancer, you should speak with your doctor about appropriate cancer screening and prevention strategies.
Q 2. Can Ibrunat 140mg be taken with other medications?
Ibrunat 140mg can interact with other medications, so it is important to inform your doctor of all medications you are taking, including prescription, over-the-counter, and herbal supplements.
Q 3. How long do I need to take Ibrunat 140mg ?
The length of treatment with Ibrunat 140mg will depend on your specific condition and response to the medication. Your doctor will monitor your progress and determine the duration of treatment.
Q 4. Can I drink alcohol while taking Ibrunat 140mg ?
Alcohol consumption should be avoided while taking Ibrunat 140mg , as it may increase the risk of certain side effects, such as liver damage. You should talk to your doctor about any concerns you have regarding alcohol use.
Q 5. Can Ibrunat 140mg cure all types of cancer?
Ibrunat 140mg has been shown to be effective in treating certain types of blood cancers, but its efficacy in other types of cancer is still being studied. It is important to remember that cancer is a complex disease with many different causes and factors, and there is no single cure that works for all types of cancer. If you have been diagnosed with cancer, it is important to work with your doctor to determine the best treatment options for your specific case.
Q 6. Should I use contraception while under this Ibrunat 140mg capsule?
Yes, It is necessary to use contraception during and even after the last dose of Ibrunat 140mg capsule. Inform your doctor if you are pregnant or think you might be or if you are planning to get pregnant.
Fact Box of Ibrunat 140mg Capsule
Molecule name: Ibrutinib
Therapeutic class: Anti Neoplastics
Pharmacological class: Bruton's tyrosine kinase (BTK) inhibitors
Ibrunat 140mg Capsule is used in the treatment of
Chronic lymphocytic leukemia (Blood cancer)
1. Small lymphocytic lymphoma
2. Waldenstrom’s macroglobulinemia
3. Chronic graft vs. host disease after failure of systemic therapy
4. Mantle cell lymphoma
- Janssen-Cilag International Ltd, Electronic Medicines Compendium (EMC), [Revised on Dec 2021] [Accessed on 18th March 2023], https://www.medicines.org.uk/emc/files/pil.10040.pdf
- Janssen Biotech, Inc, US Food and Drug Administration, [Revised on May 2022] [ 18th March 2023], https://www.imbruvica.com/files/prescribing-information.pdf
- H.G. Watson, J.I.O. Craig, L.M. Manson, Blood disease, Davidson’s Principles and Practice of Medicine, 22nd Edition, 2014, 989-1056.
- Sapna Parmar, Khilna Patel, Javier Pinilla-Ibarz, Ibrutinib (Imbruvica): A Novel Targeted Therapy for Chronic Lymphocytic Leukemia, Drug Forecast, Published on July 2014; Accessed on 18th March 2023]; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103574/pdf/ptj3907483.pdf
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