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Icupen 500mg Injection

Prescription Required

Salt Composition : Doripenem

Manufacturer : ABBOTT

Origin of Medicine : India

MRP: 6601.62
Price :1716
You Save :4886 (74%)

1 Vial(s)

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Introduction to Icupen 500mg Injection

Icupen 500mg injection contains an active component of Doripenem. It is an antibiotic medication that belongs to the carbapenem class of antibiotics. It treats various bacterial infections, including serious infections caused by multidrug-resistant organisms. It is primarily indicated for urinary tract infections, intra-abdominal infections, and infections in hospitalized patients. This medication can be used to treat infections within the abdominal cavity, such as appendicitis, peritonitis, and abscesses. This medication is also used in infections that might involve the bladder, kidneys, or other parts of the urinary system. It can be used to treat bacterial pneumonia that occurs in patients who are already hospitalized. It might be used to treat skin and soft tissue infections caused by susceptible bacteria. In some cases, it might be considered for treating bacterial meningitis (brain layer inflammation) caused by susceptible organisms.

If a patient has a known hypersensitivity or allergy to Icupen 500mg injection, they should not take this medication. Patients with severe kidney problems should consult a healthcare provider before starting this medication. Patients with a history of seizures or conditions that increase the risk of seizures should also consult a healthcare provider.  Individuals with severe liver dysfunction might experience altered drug metabolism and should always consult a healthcare provider before starting this medication. Icupen 500mg injection can be used in pediatric populations but under the guidance of a doctor. It can be used in elderly patients, but certain precautions must be taken due to age-related changes in metabolism and medical conditions.

Uses of Icupen 500mg Injection

Icupen 500mg injection is used in the following:

  • Complicated urinary tract infections (cUTIs)
  • Intra-abdominal infections
  • Hospital-acquired pneumonia (HAP)
  • Ventilator-associated pneumonia (VAP)
  • Skin and soft tissue infections
  • Bacterial meningitis

Therapeutic Effects of Icupen 500mg Injection

Icupen 500mg injection disrupts bacterial cell wall synthesis by inhibiting penicillin-binding proteins (PBPs). This interference weakens the cell wall's structure, rendering bacteria susceptible to osmotic stress and eventual cell lysis. This mechanism of action, similar to other beta-lactam antibiotics, makes this medication effective against a broad spectrum of Gram-positive and Gram-negative bacteria, aiding in treating various infections.

Interaction of Icupen 500mg Injection with other drugs

Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Luliconazole, reducing effectiveness by causing undesirable side effects. 

More Information about Icupen 500mg Injection

  • Store at room temperature, between up to  20°C to 25°C
  • Keep away from moisture, heat, and light.
  • It should not be frozen.
  • Keep away from children and pets.

How to consume Icupen 500mg Injection

Icupen 500mg injection is typically administered intravenously by a healthcare professional and is generally used for severe infections that have not responded to other less potent antibiotics due to its strong effectiveness against a wide range of bacteria.

Safety Advices for Icupen 500mg Injection

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The safety of Icupen 500mg injection during pregnancy is not well established. Pregnant women should consult their healthcare provider before using this medication.

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Breast Feeding


 Women should consult a health care professional before taking the Icupen 500mg injection.

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If you are prescribed an Icupen 500mg injection for a lung infection or any other condition, consult a doctor before starting the treatment. follow your healthcare provider's instructions precisely.

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If you have liver disease or a history of liver problems, consult inform your healthcare provider before taking an Icupen 500mg injection.

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It is generally advisable to avoid excessive alcohol consumption while on an Icupen 500mg injection. Taking alcohol might reduce the effectiveness of the medication and raise the risk of side effects, so it is unsafe to take alcohol while taking this medication.

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Icupen 500mg injection can cause you to experience side effects like dizziness or confusion that can impair your driving ability or motor skills, so you should refrain from this activity while taking this medication while taking the medication, and avoid driving while taking this medication.

Side Effects of Icupen 500mg Injection

Icupen 500mg injection causes some side effects like all medications, although not everyone will experience them. 


  • Severe allergic reactions
  • Seizures or convulsions
  • Worsening symptoms of bacterial or fungal infections
  • Severe diarrhea
  • Unusual tiredness
  • Yellowing of the eyes or skin (jaundice)
  • Dark urine


  • Nausea
  • Vomiting
  • Diarrhea
  • Headache
  • Rash
  • Itching
  • Pain at the injection site (if given intravenously)
  • Elevated liver enzymes

Word of Advice

Before starting the medication, inform your healthcare provider about any allergies, especially to beta-lactam antibiotics and any history of severe reactions or seizures. Discuss your medical history, including kidney or liver conditions, and list all medications, supplements, and herbal products you are taking. Pregnant or breastfeeding individuals should consult their healthcare provider, as Icupen 500mg injection's safety in these situations is not fully established. If you have a history of gastrointestinal disorders, diabetes, or immune system issues, tell your healthcare provider. Children and elderly individuals might require monitoring by health care providers. Check for signs of severe allergic reactions, central nervous system effects, and Clostridioides difficile infection. Complete the full course of treatment and report any unusual symptoms to your healthcare provider. Always follow healthcare provider instructions for optimal safety and treatment outcomes.


Q 1. What should I do if I miss a dose of Icupen 500mg injection?

If you miss a dose of Icupen 500mg injection, contact your healthcare provider for guidance. Sticking to the recommended dosing schedule is important, but do not double the dose to compensate for a missed one.

Q 2. How long should I take Icupen 500mg injection?

The duration of Icupen 500mg injection treatment depends on the type and severity of the infection being treated. Your healthcare provider will determine the appropriate length of treatment.

Q 3. Can I stop taking Icupen 500mg injection if I feel better?

It's important to complete the full course of Icupen 500mg injection even if your symptoms improve before the treatment is finished. Stopping prematurely can lead to incomplete eradication of the infection and potential antibiotic resistance.

Q 4. What should I do If I experience seizures or central nervous system effects?

If you experience seizures, confusion, or other central nervous system effects while taking Icupen 500mg injection, seek medical attention immediately. Inform your healthcare provider about your symptoms.

Q 5. Can I drink caffeine while on Icupen 500mg injection?

There is no specific interaction between caffeine and Icupen 500mg injection. However, consult your healthcare provider if you experience nervousness or other symptoms.

Q 6. What should I do If I accidentally take an extra dose of Icupen 500mg injection?

If you accidentally take an extra dose of Icupen 500mg injection, contact your healthcare provider for guidance. Taking more than the prescribed amount may increase the risk of side effects.

Fact Box of Icupen 500mg Injection

Molecule name: Doripenem

Therapeutic class:  Antibacterial Agents

Pharmacological class: Carbapenem Antibiotics


1. Complicated urinary tract infections (cUTIs)

2. Intra-abdominal infections

3. Hospital-acquired pneumonia (HAP)  

4. Ventilator-associated pneumonia (VAP)

5. Skin and soft tissue infections

6. Bacterial meningitis


  1. Shionogi & Co. Ltd., US Food & Drug Administration, [Revised on Apr 2013] [Accessed on 22nd August 2023],
  2. P.T. Reid, J.A. Innes, Respiratory Disease, Davidson’s Principles & Practice of Medicine, 22nd Edition, 2014, 643-732.
  3. Camille E. Beauduy, Lisa G. Winston, Beta-Lactam & Other Cell Wall- & Membrane-Active Antibiotics, Lange’s Basic & Clinical Pharmacology, 14th Edition, 2018, 795-814.


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