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Instgra 50mg Tablet 30's
Last updated on 09 Apr 2026 | 08:11 AM (IST)
₹2719
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30 TABLET(s) IN A BOTTLE
Instgra 50 mg Tablet is a prescription antiretroviral medicine used in the treatment of HIV-1 infection. It contains dolutegravir, an integrase inhibitor that works by preventing viral DNA from integrating into human cells, thereby reducing viral replication. Instgra is taken under medical supervision as part of a long-term HIV treatment regimen.
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Introduction to Instgra 50mg Tablet 30's
Instgra 50mg Tablet is an antiretroviral drug belonging to the Integrase strand transfer inhibitor category, containing the active ingredient Dolutegravir. It is used to treat human immunodeficiency virus (HIV) infection. HIV infection is mainly spread by sexual contact with anyone who has the infection or by transfer of infected blood (by sharing injection needles). This drug must be taken with other medicines used to treat HIV infection.
This drug is contraindicated in individuals with liver disease. Due to the higher concentration, caution should be taken when administering the drug to individuals with liver impairment. The dosage of this drug may need to be adjusted by your doctor, or it may need to be used with extra monitoring in these individuals to ensure its safety and efficacy. During the early stages of HIV treatment, some patients may experience an inflammatory response to opportunistic infections. This condition, immune reconstitution syndrome, can occur after starting the drug or other antiretroviral therapies. Knowing this possibility and monitoring for any signs of worsening infections or inflammatory symptoms is necessary. Inform your healthcare provider if the symptoms concern you or persist longer than usual.
It is necessary for healthcare professionals to carefully monitor patients taking this drug for any signs or symptoms of skin or hypersensitivity reactions, such as rash, blistering, or mucosal lesions. If a severe reaction is suspected, this medicine should be discontinued immediately, and appropriate medical treatment can be initiated. Patients are also advised to report any skin or hypersensitivity reactions to their healthcare provider and to seek medical emergency immediately if they experience any symptoms of a severe reaction. Tell your doctor immediately about all the medications you have been taking recently, including herbal and supplements, before taking this drug.
Uses of Instgra 50mg Tablet 30's
- Human Immunodeficiency Virus (HIV)
Therapeutic Effects of Instgra 50mg Tablet 30's
Instgra 50mg Tablet works by inhibiting the enzyme integrase, thereby reducing the virus in your body. It also increases a type of white blood cell called CD4 cells which help the body fight infection.
Interaction of Instgra 50mg Tablet 30's with other drugs
Inform your healthcare provider about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Instgra 50mg Tablets and reduce effectiveness by causing undesirable side effects.
More Information about Instgra 50mg Tablet 30's
- Store Instgra 50mg Tablet at room temperature (15°to 25°C).
- Keep the Tablet out of reach of children and pets.
How to consume Instgra 50mg Tablet 30's
It is an orally available prescription drug. Your doctor will decide the dose and duration of the drug based on the disease condition and other factors. Always take Instgra 50mg Tablet as prescribed by your doctor. Take the tablet with or without food. Do not break, chew, or crush the Tablet. Swallow the whole tablet with water.
Safety Advice for Instgra 50mg Tablet 30's
Breast Feeding
Breastfeeding is not recommended in patients taking Instgra 50mg Tablets because the medicine passes into the breast milk in small amounts and may harm your baby. Do not breastfeed during the treatment.
Alcohol
Consuming alcohol may affect the effectiveness of the Instgra 50mg Tablet. It is highly advised to stop consuming alcohol if you take this medicine.
Liver
Instgra 50mg Tablet must be cautiously administered in patients with severe liver diseases. Dose adjustments are necessary for severe liver failure. Inform your doctor if you have liver problems before initiating the therapy.
Lungs
It is unknown whether Instgra 50mg Tablets can be prescribed for patients with lung problems. Consult your doctor if you have any lung diseases before starting the treatment.
Driving
Driving vehicles or operating heavy machinery is unsafe after taking the Instgra 50mg Tablet. It may cause dizziness and impair concentration.
Pregnancy
Suppose you are pregnant or planning for pregnancy during the treatment. Please consult your doctor before taking Instgra 50mg Tablet.
Side Effects of Instgra 50mg Tablet 30's
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious
- Allergic reactions (swelling, high temperature)
- Infection, inflammation
- Inflammation of the liver; liver failure
- Joint pain
Common
- Depression
- Abnormal dreams, insomnia
- Itching, rash
- Being sick
- Stomach discomfort, pain
- Headache
- Diarrhea
- Fatigue
Word of Advice
To prevent the spread of HIV infection, avoid sharing needles or syringes, which can transmit HIV-1 infections easily. It's necessary for individuals who use injectable drugs to use sterile needles and syringes and never share them with others. Personal items like toothbrushes, razor blades, or anything with body fluids or blood should also be avoided. They should not be shared because HIV-1 can be present in blood and certain body fluids, and sharing these items could mainly transmit the virus.
FAQs about Instgra 50mg Tablet 30's
Q1.
What medicines should I avoid with the Instgra 50mg Tablet?
It is necessary to make your healthcare provider aware of any medicines you take, including herbal, complementary, or other medicines you may buy from the pharmacy or online, to ensure they are compatible with Instgra 50mg Tablet and any other anti-HIV drugs you take.
Q2.
Who should not take a Instgra 50mg Tablet?
People with a previous allergic reaction or hypersensitivity to the Instgra 50mg Tablet or its components should not take this medication.
Q3.
Do I get hepatic impairment when taking this Instgra 50mg Tablet?
The liver metabolizes this drug, so individuals with severe hepatic impairment should avoid taking Instgra 50mg Tablets, and it is necessary to ask your physician to determine the appropriateness of this medicine in individuals with liver problems.
Q4.
What is the working mechanism of Instgra 50mg Tablet in HIV treatment?
Instgra 50mg Tablet works by inhibiting the enzyme integrase, thereby reducing the virus in your body. It also increases a type of white blood cell called CD4 cells which help the body fight infection.
Q5.
What if I miss my Instgra 50mg Tablet?
If you miss a dose of the Instgra 50mg Tablet or it is almost time for the next dose schedule, do not take it. Wait and take the next dose of this Tablet at its regular time.
Q6.
Can you consume alcohol during treatment with a Instgra 50mg Tablet?
It is highly not advised to consume alcohol while on treatment with a Instgra 50mg Tablet, as alcohol might affect how this medication works in your body.
Q7.
What are some of the long-term serious side effects of treatment with Instgra 50mg Tablet?
Some serious side effects of treatment with Instgra 50mg Tablet include worsening hepatitis B, bone loss, kidney injury, pancreatitis, immune reconstitution syndrome, liver toxicity, and hypersensitivity reactions.
Fact Box of Instgra 50mg Tablet 30's
Molecule name: Dolutegravir
| Therapeutic class: Antiretroviral |
Pharmacological class: Integrase strand transfer inhibitor
| Indications: Human Immunodeficiency Virus (HIV) |
References
- Tivicay 10mg Tablets - patient information leaflet (PIL) - (EMC). [Revised on June 2022] Available at: https://www.medicines.org.uk/emc/files/pil.10057.pdf [Accessed 22 May 2023].
- ViiV Healthcare, U.S. Food & Drug Administration, [Revised on June 2020] [Accessed on 22 May 2023] https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/213983s000lbl.pdf
- Bertram G Katzung, Basic and Clinical Pharmacology, Antiviral Agents, 14th Edition, 2017, 883.
- KD Tripathi, Antiviral Drugs (Anti-retrovirus), Essentials of Medical Pharmacology, 8th Edition, 2019, 860-872.
Disclaimer
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Author Details
Written By
Sakshi Anil More
B. Pharm
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 09 Apr 2026 | 08:11 AM (IST)
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