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Intacept 50mg Injection
Last updated on 13 May 2026 | 07:19 AM (IST)
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Intacept 50 mg Injection is a prescription biologic medicine used to treat autoimmune inflammatory conditions such as rheumatoid arthritis, ankylosing spondylitis, and psoriasis. It contains etanercept, a tumor necrosis factor (TNF) inhibitor that works by reducing inflammation and slowing disease progression. Intacept is administered under medical supervision as part of a long-term autoimmune disease management plan
Sourced from:Manufacturer Authorized Distributor
Intacept 50mg Injection
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ETANERCEPTMarketer
INTAS PHARMACEUTICALS LTD
Prepaid Only. Non-Returnable.
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₹4179
MRP: ₹10,714.69
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61% Off
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ETANERCEPTMarketer
INTAS PHARMACEUTICALS LTD
Prepaid Only. Non-Returnable.
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Introduction
Intacept 50mg Injection contains the active ingredient Etanercept. It is commercially known as Enbrel and is a potent TNF inhibitor utilised to treat various autoimmune conditions, including rheumatoid arthritis, psoriasis, psoriatic arthritis, ankylosing spondylitis, and juvenile idiopathic arthritis. Rheumatoid arthritis is an autoimmune disorder characterised by chronic inflammation of the joints, leading to pain, swelling, and potential joint deformity. Psoriatic arthritis is an inflammatory joint condition occurring in some individuals with psoriasis, leading to joint pain, stiffness, and swelling. Ankylosing spondylitis is a type of arthritis that primarily affects the spine, causing pain, stiffness, and potential fusion of the vertebrae, leading to reduced flexibility. Juvenile idiopathic arthritis is a group of chronic arthritic conditions affecting children under 16, causing joint inflammation, pain, and potential damage.
Intacept 50mg Injection suppresses the immune system's overactive response and reduces inflammation, effectively improving the symptoms of these chronic inflammatory diseases. While this medication has demonstrated remarkable efficacy in managing these conditions, it is not without potential side effects, which may include injection site reactions, infections, headaches, and allergic reactions. When used in specific populations, Intacept 50mg Injection can be prescribed for pediatric and elderly patients. It is approved for use in children with juvenile idiopathic arthritis and, when appropriately administered, can be beneficial for managing symptoms in older adults with autoimmune diseases. However, as with any medication, cautious monitoring and individualised treatment plans are essential for pediatric and elderly patients to optimise safety and effectiveness.
Uses
Intacept 50mg Injection is used to treat the following:
Rheumatoid arthritis
Plaque psoriasis
Psoriatic arthritis
Ankylosing spondylitis
Juvenile idiopathic arthritis
Non-radiographic axial spondyloarthritis
How Intacept 50mg Injection Works
Intacept 50mg Injection's mechanism of action involves inhibition of tumour necrosis factor (TNF). By binding to circulating TNF-alpha and acting as a decoy receptor, this medication disrupts the inflammatory signalling pathway, suppressing immune cell activation and reducing the production of inflammatory cytokines. This neutralisation of TNF-alpha effectively mitigates inflammation, making it highly effective.
Interaction of Intacept 50mg Injection with other drugs
Methotrexate: Using Intacept 50mg Injection with methotrexate may increase the risk of serious infections, although this combination is sometimes prescribed in conditions like rheumatoid arthritis under close medical supervision.
Anakinra: Combining Intacept 50mg Injection with anakinra is generally not recommended, as it can raise the risk of severe infections and neutropenia.
Abatacept: Taking Intacept 50mg Injection along with abatacept may increase the chance of infections and is usually avoided.
Cyclophosphamide: Concurrent use of Intacept 50mg Injection with cyclophosphamide may raise the risk of malignancies and serious infections.
Live vaccines: Live vaccines such as MMR vaccine, BCG vaccine, and Varicella vaccine should be avoided during treatment with Intacept 50mg Injection, as the immune response may be weakened.
Corticosteroids: Medicines like Prednisolone used together with Intacept 50mg Injection may further suppress the immune system, increasing infection risk.
Sulfasalazine: Co-administration with Sulfasalazine may lead to a reduction in white blood cell counts in some patients.
Other biologic DMARDs: Combining Intacept 50mg Injection with biologics like Infliximab or Adalimumab is not advised because of increased immunosuppression.
Storage Conditions
Store at room temperature, between 36°F to 46°F (2°C to 8°C)
Keep away from moisture, heat, and light.
It should not be frozen.
Keep away from children and pets.
How to consume Intacept 50mg Injection
Intacept 50mg Injection can be administered via subcutaneous injection and intravenous infusion. The choice of administration route depends on the patient's condition, preferences, and the healthcare provider's recommendation, both of which have been proven effective in treating autoimmune diseases.
Safety Advices
Breast Feeding
The safety of Intacept 50mg Injection during breastfeeding is not fully established. It is recommended to consult with a healthcare provider to assess potential risks and benefits before using the medication while breastfeeding.
Alcohol
It is generally advisable to limit alcohol consumption while on this medication to avoid potential interactions or adverse effects.
Liver
Caution is advised when using Intacept 50mg Injection in individuals with liver impairment, as the drug is metabolised in the liver. Patients with significant liver damage require close monitoring, considering the potential risk of increased drug levels and adverse effects.
Lungs
If you have any lung-related problems, it's essential to inform your healthcare provider of any existing medical conditions before starting Intacept 50mg Injection treatment.
Driving
Some patients may experience dizziness, fatigue, or other side effects that could impair their ability to drive safely.
Pregnancy
The safety of Intacept 50mg Injection during pregnancy is not fully established, and its use should be carefully discussed with a healthcare provider, weighing potential risks and benefits for each case.
Side Effects
Intacept 50mg Injection causes some side effects like all medications, although not everyone will experience them.
Serious:
Serious infections
Tuberculosis (TB) reactivation
Hepatitis B reactivation
Neurological events
Allergic reactions
Common:
Injection site reactions
Upper respiratory infections
Headache
Nausea
Expert Tips
This injection may increase the risk of serious infections such as tuberculosis and hepatitis B reactivation, and may also cause neurological effects.
Patients with a history of cancer, heart failure, autoimmune disorders, or liver problems should be closely monitored.
Avoid live vaccines during treatment, and note that non live vaccines may be less effective.
Use during pregnancy or breastfeeding should be discussed carefully with a doctor.
Do not combine this medicine with other biological therapies.
Inform your doctor if you are scheduled for surgery, as the medicine may need to be stopped temporarily.
Regular monitoring and prompt reporting of side effects are important for safe and effective treatment.
Frequently Asked Questions(FAQs)
Q1.
Are there any serious side effects associated with Intacept 50mg Injection?
Yes, Intacept 50mg Injection may have serious side effects, including an increased risk of serious infections, tuberculosis and hepatitis B reactivation, and rare neurological events. Patients with a history of malignancy or heart failure should also be cautious.
Q2.
Can I receive vaccinations while on Intacept 50mg Injection?
Live vaccines should be avoided while on Intacept 50mg Injection treatment due to the risk of infection. Non-live vaccines may have reduced effectiveness, and the timing of vaccinations should be discussed with the healthcare provider.
Q3.
How often will I need to be monitored while on Intacept 50mg Injection?
Regular monitoring is essential while on Intacept 50mg Injection therapy. This includes evaluating treatment response, assessing for side effects, and monitoring for signs of infection, liver function, and other potential complications.
Q4.
Can I discontinue Intacept 50mg Injection if my symptoms improve?
It is essential not to discontinue Intacept 50mg Injection without consulting your healthcare provider. Stopping the medication abruptly may lead to a flare-up of your condition. Any changes to the treatment plan should be discussed with your healthcare provider.
Q5.
Can I travel with Intacept 50mg Injection?
Travelling with Intacept 50mg Injection may be possible, depending on the destination and duration of travel. Some formulations may allow short-term storage at room temperature, while others require refrigeration. Patients should consult with their healthcare provider or pharmacist for specific travel recommendations.
Q6.
Can I switch to Intacept 50mg Injection from another biologic medication?
Switching from one biologic medication to another should be done under the guidance of a healthcare provider. The transition may require specific considerations and monitoring to ensure safety and effectiveness.
Fact Box
Molecule name: Etanercept
| Therapeutic class: Immunomodulatory Agent |
Pharmacological class: Tumor Necrosis Factor (TNF) Inhibitor.
| Indications: 1. Rheumatoid arthritis 2. Plaque psoriasis 3. Psoriatic arthritis 4. Ankylosing spondylitis 5. Juvenile idiopathic arthritis 6. Non-radiographic axial spondyloarthritis |
References
KD Tripathi, Essentials of Medical Pharmacology, Anti rheumatoid and Antigout Drugs, 7th edition, 2013,212.
Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Dermatological Pharmacology, 12th edition, 2011, 1826.
Pfizer, Electronic medicines compendium (EMC), [Revised on 17 May 2023] [Accessed on 29 July 2023], https://www.medicines.org.uk/emc/product/3837/smpc#gref
Pfizer, US Food and Drug Administration, [Revised on Dec 2017] [Accessed on 29th July 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/103795s5556lbl.pdf
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Author Details

Written By
P. Thirumal Reddy
B. Pharm

Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 13 May 2026 | 07:19 AM (IST)

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