• Management of high blood sugar levels (Type 2 diabetes)

Invokana 100mg tablet is a sodium-glucose co-transport-2 (SGLT-2) inhibitor that stops kidney reabsorption of glucose, helping your body get rid of extra sugar through urine and lowering blood sugar levels. It can prevent heart disease in people with type 2 diabetes and also slows down kidney problems by a mechanism beyond blood glucose lowering.

Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional or vitamin supplements, and herbal products you take or have taken before the treatment. Certain medications may interact with Invokana 100mg tablet and cause undesirable side effects.

• Store below 25°C.
• Protect from light.
• Keep out of reach of children.
• Do not use it after the expiry date.

Take Invokana 100mg tablet as your physician advises. Swallow the tablet whole with water. Do not crush the tablets. Take the tablet before the first meal. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Do not double the dosage to compensate for the missed dose. If you take too much of the tablet, seek medical attention immediately. Don't stop the tablet unless advised by your doctor.

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.

Serious

• Allergic reactions - swelling of the face,mouth or throat that may result in difficulty in breathing or swallowing
• Diabetic ketoacidosis (enhanced levels of ketonein your urine or blood) - signs include rapid weight loss, feeling sick, stomach pain, excessive thirst, fast and deep breathing, confusion, sleepiness or tiredness, a sweet smell, a sweet or metallic taste or a different odor to your urine or sweat.

Common

• Low blood sugar levels (hypoglycemia)
• Urinary tract infections
• Yeast infection - redness of the penis or foreskin or in the vagina
• Changes in urination (including urinating more frequently or in larger amounts, urgent need to urinate, need to urinate at night)
• Constipation
• Feeling thirsty
• Nausea

During the treatment with Invokana 100mg tablet, your doctor will regularly monitor your kidney function via blood tests. Due to its mechanism, your urine will show the presence of sugar (glucose) while taking this medicine. If you develop symptoms such as genital or perianal pain, redness, swelling, or fever, seek immediate medical attention, as it could indicate a rare but serious infection. Monitor your feet regularly, follow foot care advice, and inform your doctor of any concerning foot issues. If you have a kidney or urinary tract infection with a fever, your doctor may advise you to stop taking canagliflozin until you recover temporarily.

Follow your doctor's prescribed medications, including canagliflozin, alongside other glucose-lowering medicines. Adhere to your doctor's guidance on diet and exercise, especially if you're on a diabetic weight control diet while taking this medication.

1. Janssen-Cilag Ltd, Electronic medicines compendium (EMC), [Revised on Aug 2023] [Accessed on 28th Sept 2023] https://www.medicines.org.uk/emc/product/8855/pil
2. Janssen Pharmaceuticals, US Food and Drug Administration (FDA), [Revised on Oct 2022] [Accessed on 28th Sep 2023] https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/204042s039lbl.pdf
3. KD Tripathi, Essentials of Medical Pharmacology, Insulin, Oral Anti Diabetic Drugs And Glucagon, 8th edition, 2019, 301
4. Goodman & Gilman's, The Pharmacological Basis of Therapeutics, Endocrine Pancreas and Pharmacotherapy of Diabetes Mellitus and Hypoglycemia, 2018, 879.