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Istamet 50mg500mg Tablet_202699 (1)
Istamet 50mg500mg Tablet_202699 (3)
Istamet 50mg500mg Tablet_202699 (2)
Istamet 50mg500mg Tablet_202699 (1)
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Istamet 50mg/500mg Tablet

Prescription Required

Salt Composition : Sitagliptin,metformin


Origin of Medicine : India

MRP: 156
Price :133
You Save :23 (15%)

15 Tablet(s) In A Strip

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Introduction to Istamet 50mg/500mg Tablet

Istamet 50mg/500mg Tablet contains an active component called the Sitagliptin and Metformin. It is a medication used in the management of type 2 diabetes. It helps to regulate blood sugar levels by targeting multiple aspects of glucose regulation. Unlike some other diabetes medications, it is not associated with significant weight gain and may even be associated with modest weight loss in some individuals. This can be a benefit for patients with type 2 diabetes who are overweight or obese. It is less likely to cause hypoglycemia (low blood sugar levels), particularly when used as directed. This can be beneficial for individuals who are at risk of experiencing hypoglycemic episodes. Some studies suggest that the use of this medication may have cardiovascular benefits, including reducing the risk of cardiovascular events, such as heart attacks or strokes, in patients with type 2 diabetes.

Individuals with a known allergy or hypersensitivity to istamet 50mg/500mg tablet or any other components of this medication should avoid using this medication. It should not be used in individuals with severe renal impairment (eGFR less than 30 mL/min/1.73 m²) or end-stage renal disease. Using it in such cases can increase the risk of developing lactic acidosis, a serious metabolic complication. Individuals with a history of metabolic acidosis, including diabetic ketoacidosis (DKA), should not use this medication. The use of this medication is not recommended in individuals with a history of heart failure, as certain studies have suggested an increased risk of cardiovascular events with this medication. Consult a healthcare provider before starting istamet 50mg/500mg tablet, especially if you are an older adult, as age-related changes in kidney and liver function may affect the dosage requirements. It is not recommended for use in children, as its safety and efficacy in pediatric populations have not been established.

Uses of Istamet 50mg/500mg Tablet

  • Type 2 diabetes management
  • Blood sugar control
  • Weight management
  • Cardiovascular health

Therapeutic Effects of Istamet 50mg/500mg Tablet

Istamet 50mg/500mg tablet works by combining its two active ingredients, which act synergistically. Sitagliptin enhances insulin release and reduces glucagon levels, while metformin decreases liver glucose production and enhances peripheral glucose uptake. Together, they help control blood sugar levels in individuals with type 2 diabetes.

Interaction of Istamet 50mg/500mg Tablet with other drugs

Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with the istamet 50mg/500mg tablet, reducing effectiveness by causing undesirable side effects.

More Information about Istamet 50mg/500mg Tablet

  • Store istamet 50mg/500mg at room temperature, between 20°C to 25°C
  • Keep away from moisture, heat, and light.
  • It should not be frozen.
  • Keep away from children and pets.

How to consume Istamet 50mg/500mg Tablet

Istamet 50mg/500mg tablet can be administered orally.. Follow the prescribed dosage and any additional instructions provided by the healthcare professional for the safe and effective use of istamet 50mg/500mg tablet.

Safety Advices for Istamet 50mg/500mg Tablet

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Istamet 50mg/500mg tablet is not recommended during pregnancy. Discuss the potential risks and benefits with a healthcare provider before using it during pregnancy.

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Breast Feeding


Istamet 50mg/500mg tablet may not be recommended for breastfeeding mothers. Consult a healthcare provider for guidance on using this medication while breastfeeding.

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Consult your healthcare provider if you have a history of lung conditions before using the istamet 50mg/500mg tablet.

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If you have liver disorders, informing your healthcare provider before starting the istamet 50mg/500mg tablet is important.

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It is not safe alcohol while taking istamet 50mg/500mg tablet, as alcohol can increase the risk of lactic acidosis.

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Istamet 50mg/500mg tablet is generally not known to impair the ability to drive or operate machinery. However, individual responses may vary, especially in cases of hypoglycemia or other adverse effects. If you experience any symptoms, consult your healthcare provider.

Side Effects of Istamet 50mg/500mg Tablet

Istamet 50mg/500mg tablet causes some side effects like all medications, although not everyone will experience them. 


  • Lactic Acidosis
  • Pancreatitis
  • Hypoglycemia


  • Diarrhea
  • Nausea
  • Vomiting
  • Gas
  • Stomach upset or pain

Word of Advice

Watch out for any signs of allergies like rash or swelling after taking istamet 50mg/500mg tablet. Regularly check how well your kidneys and liver are working. If you have any heart problems, be careful while using this medication. Pay attention to signs like feeling shaky or dizzy, which might mean your blood sugar is too low. Be aware of any new infections or if you feel sick.  If you are pregnant or breastfeeding, talk to your doctor before taking it. Tell your doctor if you have any surgeries coming up. It is better to avoid too much alcohol while taking this medication. Make sure to drink enough water, especially if you are sick. Long-term use of this medication might affect your vitamin levels, so ask your doctor about it.  Along with taking the medication, maintain a healthy diet and stay physically active as your doctor advises. Manage your stress levels and get enough rest to support your overall well-being.


Q 1. What should I do if I miss a dose of istamet 50mg/500mg tablet?

If you miss a dose of istamet 50mg/500mg tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.

Q 2. Are there any dietary restrictions while taking istamet 50mg/500mg tablet?

Follow a balanced diet as recommended by your healthcare provider while taking istamet 50mg/500mg tablet. Avoid excessive alcohol consumption, as it can increase the risk of lactic acidosis.

Q 3. How long does it take for istamet 50mg/500mg tablet to show its effects?

The onset of action may vary from person to person. Your healthcare provider can provide more information based on your specific condition.

Q 4. What should I do if I experience side effects after taking istamet 50mg/500mg tablet?

If you experience any side effects after taking istamet 50mg/500mg tablet, consult your healthcare provider immediately. They can guide you in managing the side effects and may adjust your treatment plan if necessary.

Q 5. Can I stop taking istamet 50mg/500mg tablet if I feel better?

Do not stop taking istamet 50mg/500mg tablet without consulting your healthcare provider, even if you feel better. Stopping the medication abruptly may cause your blood sugar levels to rise again.

Q 6. Can istamet 50mg/500mg tablet be used for weight loss?

Istamet 50mg/500mg tablet is not primarily used for weight loss. However, some individuals may experience modest weight loss due to improved glycemic control.

Fact Box of Istamet 50mg/500mg Tablet

Molecule name:  Sitagliptin and Metformin

Therapeutic class: Antidiabetic agent

Pharmacological class: 

1.Sitagliptin-Dipeptidyl peptidase-4 (DPP-4) inhibitor  

2. Metformin-Biguanide


1. Type 2 diabetes management

2. Blood sugar control

3. Weight management

4. Cardiovascular health


  1. Merck Sharp & Dohme (UK) Limited, Electronic Medicines Compendium (EMC), [Revised on February 2022] [Accessed on 27th Oct  2023],
  2. Merck Sharp & Dohme Corp., U.S. Food and Drug Administration, [Accessed on 27th Oct  2023],
  3. KD Tripathi, Essentials of Medical Pharmacology, Hormones, and Related Drugs, 7th edition, 2013, 274-276.


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