Ivermectin 12mg tablet is used in the following:

• Onchocerciasis (River Blindness)
• Strongyloidiasis (Threadworm Infection)
• Scabies
• Lice infestations
• Lymphatic filariasis
• Veterinary medicine (animal parasite treatment)
• Off-Label Uses (subject to ongoing research)

Ivermectin 12mg tablet works by targeting and disrupting the nervous system of parasites. It binds to specific neurotransmitter receptors in parasites' nerve and muscle cells, increasing the release of a neurotransmitter called gamma-aminobutyric acid (GABA). This excess GABA causes paralysis and eventually death of the parasites by inhibiting nerve impulses and muscle function. Its mechanism is selective for invertebrate parasites, sparing mammals and humans due to differences in the nervous system structure. This disruption of the parasites' nervous system effectively immobilizes and kills them, making it an effective treatment for various parasitic infections.

Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Ivermectin 12mg tablet, reducing effectiveness by causing undesirable side effects. 

• Store at room temperature, between up to 20°C to 25°C (68°F to 77°F).
• Keep away from moisture, heat, and light.
• It should not be frozen.
• Keep away from children and pets.

Ivermectin 12mg tablet can be administered through oral tablets or liquid solutions, topical creams or lotions for skin applications, or injections for certain cases, depending on the formulation and condition being treated. Healthcare providers determine the appropriate route of administration based on the specific circumstances and type of parasitic infection. Always follow the recommended method and dosage as directed by a healthcare professional or indicated on the medication packaging.

Ivermectin 12mg tablet causes some side effects like all medications, although not everyone will experience them. 

Serious:

• Allergic reactions
• Neurological effects
• Eye effects
• Liver effects

Common:

• Gastrointestinal disturbances
• Skin reactions
• Fatigue
• Dizziness or headache
• Muscle and joint pain
• Fever
• Appetite changes
• Sleep disturbances

Consult a healthcare provider before use, particularly if you are pregnant, breastfeeding, have liver or kidney conditions, or are immunocompromised. Discuss allergies, medications, and medical history. Consider potential interactions, especially with alcohol, and be cautious if driving or operating machinery due to possible dizziness or drowsiness. Report any severe reactions promptly. Follow prescribed dosages and completion of treatment, maintaining proper hygiene for conditions like scabies. Be aware of potential drug resistance and carefully follow guidelines to prevent it. Children may require adjusted dosages.

1. Galderma (U.K) Ltd, Electronic medicines compendium (EMC), [Revised on 28 Nov 2022] [ Accessed on 8th August 2023], https://www.medicines.org.uk/emc/product/6819/smpc#gref
2. Jennifer Keiser, James McCarthy, and Peter Hotez, Chemotherapy of Helminth Infections, Goodman & Gilman’s Pharmacological Basis of Therapeutics, 2018, 1001-1009.
3. US Food and Drug Administration, [Revised on  March 16, 2023] [ Accessed on  08/08/2023]https://www.fda.gov/inspections-compliance-enforcement-and-criminal-investigations/warning-letters/wwwIvermectin 12mg tablet4covidcom-650184-03162023#:~:text=FDA%2Dapproved%20Ivermectin 12mg tablet%20tablets%20are,are%20only%20available%20by%20prescription.