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Koate-Dvi 250IU Injection

Prescription Required


Salt Composition : Anti Hemophilic Factor (human)

Manufacturer : GRIFOLS

Origin of Medicine : India

MRP: 3558.6
Price :3380
You Save :179 (5%)

1 Vial(s)

Prepaid Only. Non-Returnable
Out of Stock

Introduction to Koate-dvi 250iu Injection

Koate-DVI 250IU Injection contains active components as Anti-hemophilic factor. It is, also known as factor VIII, is a medication used to treat hemophilia A, a genetic bleeding disorder caused by a blood clotting factor deficiency. It can be used to treat acute bleeding episodes in people with hemophilia A. This includes episodes of spontaneous bleeding and bleeding resulting from injuries or surgeries.  People with hemophilia A may require surgery for various reasons, such as joint surgeries, dental procedures, or other medical interventions. It may be used before and after surgery to prevent excessive bleeding during and after the procedure.

Individuals with a known hypersensitivity or allergy to Koate-DVI 250IU Injection or any of its components should not use this medication. Allergic reactions to it can be severe and life-threatening. It should not be used to treat hemophilia B, which a deficiency of factor IX causes. There may be concerns about using it in individuals with severe kidney dysfunction or renal failure, as it can affect the clearance of the medication from the body. Dosing adjustments may be necessary in these cases. Individuals with pre-existing cardiovascular diseases, such as a history of heart attacks or thromboembolic events, may require careful monitoring and adjusted dosing when using Anti-hemophilic factors (human). It can be safe and effective for children and  older adults with hemophilia A. Always follow the healthcare provider's recommendations for these groups.

Uses of Koate-dvi 250iu Injection

Koate-DVI 250IU Injection  is used in the following:

  • Hemophilia A treatment
  • Bleeding episode management

Therapeutic Effects of Koate-dvi 250iu Injection

Koate-DVI 250IU Injection acts as a co-factor for factor IX in the formation of tenase complex, which is essential for the conversion of prothrombin to thrombin. Thrombin, in turn, facilitates the conversion of fibrinogen into fibrin, leading to the formation of stable blood clots. This medication corrects the clotting cascade, allowing individuals with hemophilia A to form normal blood clots and effectively manage bleeding episodes or prevent them when used prophylactically.

Interaction of Koate-dvi 250iu Injection with other drugs

Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with  Koate-DVI 250IU Injection, reducing effectiveness by causing undesirable side effects. 

More Information about Koate-dvi 250iu Injection

  • Stored at room temperature from 2°C to 8°C
  • Keep away from moisture, heat, and light.
  • It should not be frozen.
  • Keep away from children and pets.

How to consume Koate-dvi 250iu Injection

Koate-DVI 250IU Injection is typically administered intravenously (IV) through either peripheral venous access for home use or central venous access devices for those with frequent bleeding episodes or difficult peripheral venous access. 

Safety Advices for Koate-dvi 250iu Injection

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There is limited information on the safety of Koate-DVI 250IU Injection in pregnant women. It is, therefore, important to talk to your doctor before using it if you are pregnant.

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Breast Feeding


It is not known whether an Koate-DVI 250IU Injection passes into breast milk. It is, therefore, important to talk to your doctor before using it if you are breastfeeding.

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Koate-DVI 250IU Injection does not directly affect lung function. However, individuals with lung issues should consult a healthcare provider before using it.

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The liver plays a role in the clearance of clotting factors, so it is important to consult a healthcare provider before taking an Koate-DVI 250IU Injection.

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It's generally unsafe to take alcohol while on an Koate-DVI 250IU Injection. Alcohol can increase the risk of injury, which can be especially concerning for individuals with hemophilia A.

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Koate-DVI 250IU Injectiondoes not cause any side effects that would affect your ability to drive. However, if you experience dizziness or other unusual side effects, it's best to consult your healthcare provider.

Side Effects of Koate-dvi 250iu Injection

Koate-DVI 250IU Injection causes some side effects like all medications, although not everyone will experience them. 


  • Allergic reactions
  • Formation of inhibitors
  • Thromboembolic events
  • Circulatory overload


  • Infusion site reactions
  • Headache
  • Fever
  • Chills

Word of Advice

When using an Koate-DVI 250IU Injection, it is important to be cautious of potential allergies, watch for inhibitors that can reduce its effectiveness, and take care if you have had blood clots or heart issues before. Kids and older adults might need different doses, and if you are pregnant or breastfeeding, consult your doctor. Proper storage, careful driving, and alcohol moderation are important. Watch for infection signs and plan for surgery. Learn how to use it correctly, discuss travel plans with your healthcare team, and seek support for your mental well-being. Inform your doctor about all medications if needed. In emergencies, know what to do for immediate bleeding control. 


Q 1. What should I do in a bleeding emergency using an Koate-DVI 250IU Injection?

In a bleeding emergency, individuals should follow their emergency treatment plan, administer Koate-DVI 250IU Injection as prescribed, and seek immediate medical attention if necessary. Proper preparedness can help control bleeding effectively.

Q 2. What are the serious side effects or complications associated with Koate-DVI 250IU Injection?

Serious side effects of Anti-hemophilic factors (human) can include allergic reactions (including anaphylaxis), the development of inhibitors, thromboembolic events (blood clots), and circulatory overload. Regular monitoring and communication with healthcare providers help manage these risks.

Q 3. Can I participate in sports and physical activities while on Koate-DVI 250IU Injection?

Individuals with hemophilia A can participate in sports and physical activities while on Koate-DVI 250IU Injection. Still, choosing activities that are safe and suitable for your condition is crucial. Consult with your healthcare team for exercise and sports participation guidance, and take necessary precautions to prevent injuries.

Q 4. What should I do if I miss a dose of Koate-DVI 250IU Injection?

If you miss a scheduled dose of Koate-DVI 250IU Injection, contact your healthcare provider or treatment center for guidance. They can help you determine whether you need to administer the missed dose and how to adjust your treatment plan.

Q 5. Can I self-administer the Koate-DVI 250IU Injection at home, or must I visit a healthcare facility for every infusion?

Many individuals with hemophilia A are trained to self-administer Anti-hemophilic factors (human) at home, especially for routine prophylactic infusions. Home administration can provide greater flexibility and convenience, but it's essential to receive proper training and guidance from your healthcare team.

Q 6. How often do I need to take the Koate-DVI 250IU Injection?

The frequency of Koate-DVI 250IU Injection infusions can vary depending on the individual's treatment plan and bleeding risk. Some people with hemophilia A may require prophylactic (preventive) infusions several times a week, while others may use it on an as-needed basis for bleeding episodes. Your healthcare team will determine the appropriate dosing schedule for you.

Fact Box of Koate-dvi 250iu Injection

Molecule name: Anti-hemophilic factor (human)   

Therapeutic class:  Antihemorrhagics

Pharmacological class:  Clotting Factors


1. Hemophilia A treatment 

2. Bleeding episode management


  1. KD Tripathi, Essentials of Medical Pharmacology, Drugs affecting coagulation, bleeding, and thrombosis, 7th edition, 2013, 217.
  2. Grifols Therapeutics Inc, [Revised on August 2012] [ Accessed on  15th Sept 2023],
  3. Baxter Healthcare Corporation, US Food and Drug Administration, [Revised on March 2010] [ Accessed on 15th Sept 2023],


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