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Krabeva 100mg Injection is indicated to treat the following conditions:

Glioblastoma multiforme (brain cancer)
Persistent, recurrent, or metastatic breast cancer
Metastatic cervical cancer
Advanced kidney cancer
Metastatic colorectal cancer
Advanced non-small-cell lung cancer
Liver Cancer- Hepatocellular carcinoma
Cancers of the ovary, cervical, fallopian tube, or primary peritoneal cancer

"}},{"id":"147e4925-15e2-4484-8d7e-459fe14a125a","type":"PARA","position":3,"content_placement":1,"data":{"heading":"Therapeutic Effects of Krabeva 100mg Injection","text":"

Krabeva 100mg Injection is a recombinant humanized monoclonal antibody that works as a targeted therapy in the treatment of various advanced cancers. It produces its action by selectively binding to the protein called vascular endothelial growth factor A (VEGF-A), present in the lining of blood and lymph vessels in the body. It interrupts the interaction of VEGF-A with its receptors. This further inhibits the formation of blood vessels that supply oxygen and nutrients to the tumor. As a result, it slows down the rate of progression of cancer.

"}},{"id":"61a7cb96-58ab-4d87-b677-8588fa0d46c0","type":"PARA","position":4,"content_placement":1,"data":{"heading":"Interaction of Krabeva 100mg Injection with other drugs","text":"

Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional and vitamin supplements, and herbal products you take or have taken before the treatment. Certain medications may interact with Krabeva 100mg Injection and cause undesirable side effects.

"}},{"id":"cf44e7fc-cdb7-4fba-ac60-64d37501e54c","type":"PARA","position":5,"content_placement":1,"data":{"heading":"More Information about Krabeva 100mg Injection","text":"

Store Krabeva 100mg Injection at 2˚C to 8˚C. Do not freeze or shake.
Protect from light. Keep out of reach of children.

"}},{"id":"e6652653-40ca-4f6d-a420-f0f74a2ced08","type":"PARA","position":6,"content_placement":1,"data":{"heading":"How to consume Krabeva 100mg Injection","text":"

Your physician or nurse will administer Krabeva 100mg Injection as an intravenous infusion. The infusion should be given immediately after the dilution.

"}},{"id":"7e0eaf68-5e3d-498a-8c49-b3bc2a0be565","type":"SAFETY_ADVICE","position":7,"content_placement":2,"data":{"heading":"Safety Advice for Krabeva 100mg Injection","safety_list":[{"id":"28dd2e83-7c41-41e5-a9ff-376d1a22d67a","advice":"Breast Feeding","tag":"unsafe","description":"

It is recommended to avoid breastfeeding for a minimum of 6 months after your treatment with Krabeva 100mg Injection as this medicine may interfere with the growth of your child.

","imageUrl":"https://assets.mrmed.in/others/file-1674132409667-45039420-Breatfeeding.jpg"},{"id":"d75b11ab-72f8-4c86-8e65-c8df73f938ea","advice":"Alcohol","tag":"Consult your doctor","description":"

Consult your doctor to know if it is safe to consume alcohol while you are on treatment with Krabeva 100mg Injection as only limited studies are available.

","imageUrl":"https://assets.mrmed.in/others/file-1674132415913-10337479-Alcohol.jpg"},{"id":"451afd56-d514-423d-b357-29673d02efe9","advice":"Liver","tag":"Consult your doctor","description":"

Inform your physician before starting Krabeva 100mg Injection if you have liver diseases to avoid any serious side effects.

","imageUrl":"https://assets.mrmed.in/others/file-1674132424807-417765861-Liver.jpg"},{"id":"de06044d-2eed-4c27-8338-fc983ad79820","advice":"Lungs","tag":"Consult your doctor","description":"

Inform your doctor if you have any lung conditions before starting treatment with Krabeva 100mg injection

","imageUrl":"https://assets.mrmed.in/others/file-1674132427859-226731771-Lungs.jpg"},{"id":"aac8b98e-3cd6-486f-9e33-7f5087c56144","advice":"Driving","tag":"unsafe","description":"

Avoid driving or using machinery while you are on your treatment with Krabeva 100mg Injection as it is related to cause dizziness or sleepiness.

","imageUrl":"https://assets.mrmed.in/others/file-1674132431331-421990512-Driving.jpg"},{"id":"bb5890a4-40aa-40ee-bb3d-287df326a145","advice":"Pregnancy","tag":"unsafe","description":"

Inform your physician before starting your treatment with Krabeva 100mg Injection in case, if you are pregnant or planning for pregnancy as this medicine may cause harm to the unborn baby and interrupt the formation of blood vessels.

","imageUrl":"https://assets.mrmed.in/others/file-1674132401469-949914510-Pregnancy.jpg"}]}},{"id":"2b6fddc5-eea6-40d6-8c28-4528b885ffe3","type":"PARA","position":8,"content_placement":1,"data":{"heading":"Side Effects of Krabeva 100mg Injection","text":"

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.

Serious:

Headache
Vision changes
Confusion
Severe allergic reactions
High Blood pressure
Delayed wound healing following surgery
Protein in urine
Severe infections
Blood clots in arteries and blood vessels of lungs
Gut perforation
Nosebleeds and bleeding risk
Heart problems with an increase in heart rate
Mouth sores, dryness
Shortness of breath

Common:

Numbness in hands or feet
Weakness and lack of energy
Diarrhoea, nausea, vomiting, abdominal pain
Constipation
Loss of appetite
Weight loss
Changes in taste and speech
Decrease in counts of white blood cells
Fever
Dry skin
Back pain

"}},{"id":"bb509bd4-74b7-49b7-be64-56db2f37c4ce","type":"PARA","position":9,"content_placement":1,"data":{"heading":"Word of Advice","text":"

It is vital to inform your physician before taking Krabeva 100mg Injection if you have the following conditions:

Have conditions involving inflammation in the stomach (ulcer, colitis).
Experience allergic reactions to Krabeva 100mg Injection or its ingredients.
Have recently undergone surgery as it is associated with the risk of bleeding.
Have diabetes, hypertension, or heart problems.

"}},{"id":"fa465251-efcd-4e7f-bb0c-32e6fc6b237a","type":"FAQ","position":10,"content_placement":2,"data":{"heading":"FAQs about Krabeva 100mg Injection","faq_list":[{"id":"c27e1e69-9289-454e-9e37-acdfd2dc02e2","question":"

Is Krabeva 100mg Injection used as standalone treatment in cancers?

","answer":"

Krabeva 100mg Injection is a recombinant monoclonal antibody that belongs to the immunotherapy class of cancer treatment. It can either be used as monotherapy or in combination with chemotherapy or immunotherapy medications to improve the overall survival rate.

"},{"id":"1bc969ab-8dea-483d-8105-97c5c0f9a81b","question":"

Is it safe for women to use Krabeva 100mg Injection?

","answer":"

While for women with reproductive potential subjected to Krabeva 100mg Injection, it is advised to discuss with your doctor regarding the effective birth control methods during the treatment. Also to be continued for a minimum of 6 months after the treatment course completion as this medicine may impair fertility.

"},{"id":"e2c05b49-4532-4249-a24b-7da5e21599b3","question":"

Is it safe to undergo a surgery during the treatment with Krabeva 100mg Injection?

","answer":"

Krabeva 100mg Injection is associated with increased risk of bleeding complications and poor wound healing. Hence it is suggested to avoid planning for surgery and maintain an interval of 28days before or after surgery.

"},{"id":"5526af7d-77ab-42c9-a691-84a0de478752","question":"

Do the side effects of Krabeva 100mg Injection last for a chronic period?

","answer":"

All the side effects that are relatively caused by Krabeva 100mg Injection occur until the drug concentration stays in the body. It is found that this medicine will be contained in our body for almost 4 months after the final dose.

"},{"id":"b8759b7f-9516-4e92-9903-b30196ddbd50","question":"

How is Krabeva 100mg Injection administered?

","answer":"

Krabeva 100mg Injection is given intravenously through infusion and the amount of drug will be measured based on the patient’s body weight, height and age. The first dose will be administered for 90 minutes and if well tolerated the infusion time can be reduced to 30 minutes.

"},{"id":"46a8008d-c78f-497b-8cbf-425e8ced4769","question":"

Can I take Krabeva 100mg Injection if I am pregnant?

","answer":"

"}]}},{"id":"72303107-b247-4816-82ee-87727e034cb0","type":"PARA","position":11,"content_placement":3,"data":{"heading":"Fact Box of Krabeva 100mg Injection","text":"

Molecule name: Bevacizumab

Therapeutic class: Anticancer

Pharmacological class: VEGF Inhibitor

Indications:

1. Glioblastoma multiforme (brain cancer)

2. Persistent, recurrent, or metastatic breast cancer

3. Metastatic cervical cancer

4. Advanced kidney cancer

5. Metastatic colorectal cancer

6. Advanced non-small-cell lung cancer

7. Liver Cancer- Hepatocellular carcinoma

8. Cancers of the ovary, cervical, fallopian tube, or primary peritoneal cancer

"}},{"id":"a5a87379-c7a7-449e-b9d7-890de45e4126","type":"PARA","position":12,"content_placement":3,"data":{"heading":"References","text":"

1. Roche Products Limited, Electronic Medicines Compendium (EMC), [Revised on Jan 2022] [Accessed on 21/11/2022], https://www.medicines.org.uk/emc/files/pil.3885.pdf
2. G.G. Dark, A.R. Abdul Razak, Oncology, Davidson's Principles & Practice of Medicine, 22nd Edition, 2014, 259-282.
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