KRABEVA 100MG INJECTION

Introduction:

Krabeva 100mg Injection is an anticancer medicine consisting of the active ingredient Bevacizumab. It is indicated along with other chemotherapy drugs to treat metastatic breast cancer, brain cancer, cervical cancer, kidney cancer, lung cancer, and colorectal cancer. It is also used to treat cancers of the ovary, fallopian tube or primary peritoneal cancer. Use effective birth control during the treatment and for at least six months after the last dose. Bevacizumab Injection is not recommended for adolescents and children under the age of 18. 
 

Constipation, appetite loss, runny nose, fever, skin problems, and weight loss are common side effects of Krabeva 100mg Injection. Before starting treatment with this medicine, let your doctor know if you have high blood pressure, high blood sugar, stomach disorders, heart problems, or have recently undergone surgery.

Uses of Krabeva 100mg Injection:

Krabeva 100mg Injection is indicated to treat the following conditions:

• Glioblastoma multiforme (brain cancer)
• Metastatic breast cancer
• Persistent, recurrent, or metastatic cervical cancer
• Advanced kidney cancer
• Advanced cancer in the colon or rectum
• Advanced non-small-cell lung cancer
• Cancers of the ovary, fallopian tube, or primary peritoneal cancer

How Krabeva 100mg Injection works:

Krabeva 100mg Injection binds to the protein called vascular endothelial growth factor A (VEGF-A), present in the lining of blood and lymph vessels in the body. It interrupts the interaction of VEGF-A with its receptors. This further inhibits the formation of blood vessels that supply oxygen and nutrients to the tumor. As a result, it slows down the rate of progression of cancer.
 

Interaction with other drugs:

Inform your doctor about any medications you are taking or have taken before the treatment.

More Information:

• Store at 2˚C to 8˚C. Do not freeze or shake. Protect from light.
• Keep out of reach of children.

References:

1. Roche Products Limited, Electronic Medicines Compendium (EMC), [Revised on Jan 2022] [Accessed on 24/05/2022], https://www.medicines.org.uk/emc/files/pil.3885.pdf
2. G.G. Dark, A.R. Abdul Razak, Oncology, Davidson's Principles & Practice of Medicine, 22nd Edition, 2014, 259-282.
3. KD Tripathi, Anticancer Drugs, Essentials of Medical Pharmacology, 8th Edition, 2019, 915-936.
4. Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.

How to use Krabeva 100mg Injection:

Your physician or nurse will administer this injection as an intravenous infusion.

Safety Advice:

Pregnancy:

This medicine causes damage to the fetus. Inform your physician before starting this treatment if you are pregnant or think you might be pregnant. 

Breastfeeding: 

Discuss with your physician before taking this injection if you are a breastfeeding mother.

Liver:

Inform your physician before starting this treatment if you have liver diseases. 

Kidney:

Inform your physician before starting this treatment if you have kidney diseases. 

Driving: 

Avoid driving or using machinery if you experience headache, blurred vision or any such symptoms after taking this medicine.

Others:

Inform your physician if you:

• Have conditions involving inflammation in the stomach (ulcer, colitis).
• Experience allergic reactions to Bevacizumab or its ingredients.
• Have recently undergone surgery.
• Have diabetes, hypertension, or heart problems.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Serious:

• Headache
• Vision changes
• Confusion
• Severe allergic reactions
• High BP
• Delayed wound healing following surgery
• Protein in urine
• Severe infections
• Blood clot in arteries and blood vessels of lungs
• Gut perforation
• Nose bleeds
• Heart problems
• Mouth sores, dryness

Common:

• Numbness
• Weakness and lack of energy
• Diarrhea, nausea, vomiting, abdominal pain
• Constipation
• Loss of appetite
• Weight loss
• Changes in taste and speech