• HIV-1 Infection

Lazid N Tablet is a combination of three antiretroviral medicines. Lamivudine and Zidovudine work by inhibiting the reverse transcriptase enzyme of HIV, restricting viral genome replication, and reducing the production of new infectious viral particles. It mainly interferes with reverse transcription and inhibits the spread of HIV. Nevirapine directly binds to reverse transcriptase (RT) and blocks RNA-dependent and DNA-dependent polymerase activities by disrupting the enzyme. 

Inform your healthcare provider about all your medicines, including prescription, over-the-counter, nutritional, supplements, and herbal products. Certain medications, including ganciclovir, interferon alfa, and ribavirin, may exacerbate the toxicity of zidovudine interaction with Lazid N Tablet and reduce its effectiveness by causing undesirable side effects.

• Store Lazid N Tablet below 30°C
• Keep the medicine out of reach of children and pets

Take the Lazid N Tablet as advised by your physician. Swallow the tablets whole and intact. This tablet should be taken with food. Do not crush, chew, or open the medicine. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Only stop taking the medicine if your doctor advises you to stop.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Serious

• Lactic acidosis (breathing difficulties along with weakness in limbs, stomach pain, vomiting, and drowsiness)
• Severe skin reactions and rash (blisters, red or inflamed eyes, swelling of the face, mouth sores, joint aches, fever, tiredness)
• Liver problems (yellowing of skin, eyes, fever, tea-colored urine, light-colored stools, pain in right side of ribs, loss of appetite)
• Osteonecrosis (stiffness and pain in joints, difficulty moving)
• Symptoms of muscle weakness or infection
• Loss of fat from legs, face, and arms

 Common

• Nausea
• Diarrhea
• Headache, dizziness
• Cough
• Difficulty sleeping

Follow your doctor's instructions concerning high-risk activities such as unprotected sex and personal items with body fluids or blood on them, like toothbrushes, razor blades, and needles. It is advised to practice safe sex by using a condom to lower the chance of sexual contact with semen, blood, or vaginal secretions. If you forgot to take the Lazid N Tablet, take your next dose at the scheduled time. Do not take a double dose to make up for a forgotten dose.

1. Micro Labs USA Inc, US Food and Drug Administration,[ Revised on August 2018] [ Accessed on 19th May 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/205626s000lbl.pdf
2. Lamivudine, Nevirapine, Zidovudine. South Ruislip, Middlesex: Aurobindo Pharma - Milpharm Ltd. Prescribing information. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/pepfar/021939PI.pdf   [ Accessed on 19th May 2023].
3. HIV drug resistance database. Available at: https://hivdb.stanford.edu/pages/linksPages/NVP_3TC_AZT_GenericCombination.pdf  [ Accessed on 19th May 2023].
4. KD Tripathi, Essentials of Medical Pharmacology, Antiviral drugs,7th edition, 2013, 806 - 811.
5. Goodman & Gilman's, The Pharmacological Basis of Therapeutics, Antiretroviral agents and treatment of HIV infection, 12th edition, 2011, 1632-1644.