Lynparza 150mg Tablet is an anticancer medicine containing Olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor. It is used in certain cancers, including ovarian, breast, pancreatic and prostate cancers. In India, Olaparib is also approved in combination with Durvalumab for maintenance treatment of certain patients with advanced or recurrent endometrial cancer.

Lynparza 150mg Tablet is used in certain patients with:

• Ovarian, fallopian tube or primary peritoneal cancer, particularly in maintenance treatment settings involving BRCA mutations or homologous recombination deficiency

• BRCA-mutated, HER2-negative high-risk early breast cancer as adjuvant treatment after chemotherapy

• BRCA-mutated, HER2-negative metastatic breast cancer

• BRCA-mutated metastatic pancreatic adenocarcinoma as maintenance treatment

• HRR gene-mutated metastatic castration-resistant prostate cancer

• BRCA-mutated metastatic castration-resistant prostate cancer in combination with abiraterone and prednisone or prednisolone

• Advanced or recurrent endometrial cancer in combination with Durvalumab for maintenance treatment in patients whose disease has not progressed following first-line Durvalumab with platinum-based chemotherapy

Olaparib blocks PARP enzymes involved in repairing damaged DNA. Cancer cells with defects in other DNA repair pathways, such as those involving BRCA proteins, may be particularly dependent on PARP-mediated repair. Blocking this pathway can cause the accumulation of DNA damage and may lead to the death of cancer cells.

Tell your doctor about all medicines, supplements and herbal products you are taking. Some medicines can change the amount of Olaparib in the blood.

• Strong or moderate CYP3A inhibitors may increase Olaparib levels and may require avoidance or dose adjustment.

• Strong or moderate CYP3A inducers may reduce Olaparib levels and should generally be avoided.

• Other medicines that affect blood cell counts may increase the risk of bone marrow suppression.

• Tell your doctor about all anticancer medicines you are receiving, including combination treatments.

• Store Lynparza 150mg Tablet in the original package.

• Keep it at room temperature, generally between 20°C and 25°C.

• Keep the medicine away from children.

• Protect the tablets from excessive heat and moisture.

• Take Lynparza 150mg Tablet exactly as prescribed by your doctor.

• The usual recommended dose of Olaparib is 300mg twice daily, which corresponds to two 150mg tablets twice daily.

• Take it with or without food.

• Swallow the tablets whole with water.

• Do not chew, crush, dissolve or divide the tablets.

• Take the doses at approximately the same times each day.

• If you miss a dose, skip it and take the next dose at the scheduled time. Do not take an extra dose to make up for the missed one.

Side effects are unwanted symptoms that can occur during treatment. Not everyone experiences them.

Common side effects

• Nausea

• Vomiting

• Diarrhoea

• Tiredness or weakness

• Decreased appetite

• Headache

• Dizziness

• Indigestion

• Changes in taste

• Anaemia

• Decreased white blood cell or platelet counts

• Cough

• Shortness of breath

Serious side effects

Contact your doctor promptly if you develop:

• Persistent or severe changes in blood cell counts

• Unusual bleeding, bruising or recurrent infections

• New or worsening breathlessness or cough

• Symptoms of a blood clot, such as sudden chest pain, breathing difficulty or swelling of a limb

• Yellowing of the skin or eyes or other signs of liver problems

• Persistent fever, weakness or other symptoms that do not improve

Lynparza has been associated with serious conditions including myelodysplastic syndrome/acute myeloid leukaemia, pneumonitis, venous thromboembolism and liver injury.

• Have your blood counts checked as advised by your doctor, usually before and regularly during treatment.

• Take Lynparza at the same times each day to maintain a consistent treatment schedule.

• Do not stop treatment or change the dose without speaking to your doctor.

• Tell your doctor about any new medicines, supplements or herbal products before taking them.

• Report persistent fever, unusual bruising, bleeding or signs of infection.

• Seek medical attention for new or worsening breathlessness or cough.

• Tell your doctor if you develop symptoms that could indicate a blood clot, such as sudden chest pain or difficulty breathing.

• Avoid grapefruit or grapefruit juice unless your doctor specifically advises otherwise, as it may affect Olaparib levels.

• Women who can become pregnant should discuss appropriate contraception with their doctor before starting treatment.

• If you miss a dose, do not take an extra tablet. Take the next dose at its usual time.