This medicine is indicated to treat the following conditions:

• Acute Myeloid Leukemia with 20-30% blasts in patients who are not eligible for Haemopoietic stem cell transplant
• High-risk Myelodysplastic syndrome (MDS)
• Chronic myelomonocytic leukaemia.

Met-MDS 100mg Injection binds to RNA and DNA, interrupts their activity in actively multiplying cells and exhibits a toxic effect on cancer cells.

Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional and vitamin supplements, and herbal products you take or have taken before the treatment. Certain medications may interact with Met-MDS 100mg Injection and cause undesirable side effects. 

• Store at 25°C. 
• Keep out of reach of children.

Take Met-MDS 100mg Injection only under the supervision of your physician. Your physician will decide the dose based on your height, weight and general condition. Met-MDS 100mg Injection shall be given under the skin of your thigh, stomach or upper arm.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Serious:

• Drowsiness
• Shivering
• Jaundice
• Stomach bloating
• Unusual bleeding or bruising
• Reduced urination
• Increased thirst
• Dizziness
• Confusion
• Chest pain
• Breathlessness
• Allergies

Common:

• Disturbances in the blood count (RBC, WBC, Platelets)
• Nausea, vomiting, diarrhea
• Constipation
• Tiredness
• Skin reactions like redness and pain at the site of injection
• Decreased appetite
• Dizziness
• Pain in extremities
• Joint pain
• Stomach pain
• Headache
• Sore nose and throat
• Rashes and bruising

Inform the doctor if the patient has any allergy reactions, respiratory problems,kidney, liver, heart problems and medication taken for different medical conditions before taking Met-MDS 100mg Injection as they worsen the condition. Avoid using this Met-MDS 100mg Injection if the patient is planning for pregnancy or during pregnancy and in breast feeding mothers as this medicine causes harmful effects in the developing baby. Take Met-MDS 100mg Injection only under the supervision of the physician. Doctors will decide the dose based on the patient's height, weight and general condition. It is administered under the skin of your thigh, stomach or upper arm.

1. K. Gaston and P.-S. Jayaraman, Transcriptional repression in eukaryotes: Repressors and repression mechanisms, Cellular and Molecular Life Sciences, [May 2003], 60(4):721-741, [Accessed on 5th Apr 2021] https://www.researchgate.net/publication/7094896_Transcriptional_repression_in_eukaryotes_Repressors_and_repression_mechanisms
2. Roman M. Shapiro & Alejandro Lazo-Langner, Systematic review of azacitidine regimens in myelodysplastic syndrome and acute myeloid leukemia, BMC Hematology, 2018 [Accessed on 3rd Apr 2021] https://bmchematol.biomedcentral.com/articles/10.1186/s12878-017-0094-8
3. Bristol-Myers Squibb, Electronic Medicines Compendium (EMC), [Revised on Oct 2021] [Accessed on 2nd Dec 2021], https://www.medicines.org.uk/emc/files/pil.6468.pdf 
4. Leukaemia Care, [Revised on Jul 2020] [Accessed on 2nd Dec 2021], https://media.leukaemiacare.org.uk/wp-content/uploads/Chronic-Myelomonocytic-Leukaemia-CMML-Web-Version.pdf