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Mezolam 5mg Injection
Last updated on 31 Mar 2026 | 09:31 AM (IST)
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Introduction to Mezolam 5mg Injection
Mezolam 5mg injection is an anaesthetic drug in the benzodiazepine category containing the active ingredient Midazolam. It treats certain conditions like status epilepticus (which is a prolonged and continuous seizure activity or recurrent seizures without a return to baseline neurological function between seizures), preoperative sedation (aims to help relax patients and reduce anxiety before surgery), and amnesia (memory loss).
This injection is contraindicated for patients with known hypersensitivity or allergy to the drug, and it is not advised to administer the drug to them. Also, this drug is contraindicated in patients with acute narrow-angle glaucoma (Narrow-angle glaucoma is a specific type of glaucoma that can cause a sudden increase in eye pressure). Benzodiazepines should be avoided in patients with this condition because they may further increase intraocular pressure, which can be harmful. Suppose you have severe breathing problems, such as chronic obstructive pulmonary disease (COPD) or asthma. In that case, informing your doctor or nurse before being administered Mezolam 5mg injection for conscious sedation is important. This drug can cause respiratory depression, which means it can slow down or decrease your respiratory function.
Report to your physician if you suspect pregnancy, breastfeeding, or planning to have a baby. This drug during breastfeeding is unsafe because it tends to get excreted in human milk. Consult your doctor for more advice. Mezolam 5mg injection is not intended for epidural or intrathecal administration due to the preservative benzyl alcohol in the dosage form. Benzyl alcohol has been linked with serious adverse effects resulting in neurological toxicity.
Uses of Mezolam 5mg Injection
- Status epilepticus
- Preoperative sedation
- Amnesia
Therapeutic Effects of Mezolam 5mg Injection
By enhancing the inhibitory effects of a neurotransmitter called gamma-aminobutyric acid (GABA), Mezolam 5mg injection produces a range of effects, including sedation, anxiolysis (reduction of anxiety), muscle relaxation, anticonvulsant activity, and amnesia.
Interaction of Mezolam 5mg Injection with other drugs
Inform your physician about any prescribed medications, over-the-counter medicines, and nutritional or vitamin supplements you have taken before the treatment. Certain medications may interact with Mezolam 5mg injection and cause undesirable side effects.
More Information about Mezolam 5mg Injection
- Do not store Mezolam 5mg injection above 25 °C.
- Keep out of sight and reach of pets and children
- Do not freeze.
How to consume Mezolam 5mg Injection
Mezolam 5mg injection will be administered to you by a healthcare professional in a hospital setting. It is usually administered as an intravenous injection into a vein. Your doctor will decide the dose, route of administration, and frequency based on your disease condition and other factors.
Safety Advice for Mezolam 5mg Injection
Breast Feeding
Taking Mezolam 5mg injection during breastfeeding is unsafe because it tends to get excreted in human milk.
Alcohol
Consuming alcohol may affect the effectiveness of Mezolam 5mg injection. It is highly advised to stop consuming alcohol if you take this medicine.
Liver
Inform your doctor if you have liver disease because Mezolam 5mg injection should be used cautiously with a liver condition.
Lungs
It is unknown whether Mezolam 5mg injection is safe for patients with lung problems. Consult your doctor if you have lung disease before starting the treatment.
Driving
Driving vehicles or operating machinery while taking Mezolam 5mg injection is unsafe because it may cause drowsiness and impair your cognitive and motor skills.
Pregnancy
If you are pregnant, suspecting, or planning for the pregnancy, report to your doctor before starting the treatment with Mezolam 5mg injection.
Side Effects of Mezolam 5mg Injection
Side Effects are unwanted symptoms caused by medicines. Although all medicines cause side effects, not everyone gets them.
Common
- Injection site reactions (redness, pain, swelling)
- Nausea
- Vomiting
- Drowsiness
- Cough
- Headache
- Hiccup
- Dry mouth
- Feeling confused
Word of Advice
Consumption of alcohol or other sedatives alongside this drug can increase the sedative effects and lead to excessive drowsiness. It is advisable to avoid alcohol and other sedatives during the period of this drug use. Ask your physician or pharmacist for clarification if you have any doubts about the medicine. Keep Mezolam 5mg injection away from excessive moisture and heat, as they can degrade the medication. Store them in a cool, dry place.
FAQs about Mezolam 5mg Injection
Q1.
What are the common side effects of Mezolam 5mg injection?
Common side effects of Mezolam 5mg injection may include drowsiness, dizziness, confusion, headache, changes in coordination, and nausea. These side effects are usually temporary and set back to normal as the medication is eliminated.
Q2.
How is Mezolam 5mg injection administered?
Mezolam 5mg injection can be administered orally, intravenously, intramuscularly, or as a nasal spray. The route of administration varies on the specific medical indication and the healthcare provider's judgement.
Q3.
How quickly does Mezolam 5mg injection take effect?
The onset of action of this drug can vary depending on the route of administration. When given intravenously, its effects are usually felt within 1 to 5 minutes. Orally administered Mezolam 5mg injection generally takes longer to take effect, typically within 15 to 60 minutes.
Q4.
How long does the soothing effect of Mezolam 5mg injection last?
The duration of the soothing effect of Mezolam 5mg injection depends on various factors such as dosage, individual metabolism, and other medications being used. Generally, the sedative effects of this drug can last between 2 and 6 hours.
Q5.
Whether Mezolam 5mg injection can be used in children?
Mezolam 5mg injection can be used in children, but a paediatrician should carefully determine the dosage and administration. It is commonly used to provide sedation and reduce anxiety in paediatric patients undergoing medical procedures.
Q6.
Are there any contraindications for Mezolam 5mg injection?
Mezolam 5mg injection is contraindicated in individuals with a known hypersensitivity to benzodiazepines. Caution is required in patients with severe respiratory insufficiency, acute narrow-angle glaucoma, or a history of substance abuse.
Fact Box of Mezolam 5mg Injection
Molecule Name: Midazolam | Therapeutic class: Anaesthetics |
Pharmacological class: Benzodiazepines | Indications: 1. Status epilepticus 2. Preoperative sedation 3. Amnesia |
References
- Hameln Pharma Ltd, Electronic medicines compendium (EMC), [ Revised on April 2020] [ Accessed on 31st May 2023], https://www.medicines.org.uk/emc/files/pil.6420.pdf
- Fresenius Kabi, US Food and Drug Administration, [ Revised on March 2017] [Accessed on 31st May 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208878Orig1s000lbl.pdf
- Midacip Nasal Spray; Ciplamed; [Accessed on 31st May 2023] https://ciplamed-library.com/content/midacip-nasal-spray
- Goodman & Gilman's, The Pharmacological Basis of Therapeutics, General anaesthetics and therapeutic gases, 12th edition, 2011, 548.
- KD Tripathi, Essentials of Medical Pharmacology, General anaesthetics, 7th edition, 2013, 383.
Disclaimer
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Author Details
Written By
Dr. B. Deiva
Pharm D
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 31 Mar 2026 | 09:31 AM (IST)
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