MIBOR 2MG INJECTION

Introduction:

Mibor 2mg Injection consists of the active substance Bortezomib. It is a chemotherapy medication indicated for the treatment of multiple myeloma and mantle cell lymphoma. Multiple myeloma refers to cancerous progression of plasma cells that are predominant in the bone marrow. Mantle cell lymphoma is a less common type of cancer that affects the lymph nodes.

This medication is concomitantly used with other chemotherapy medicines like pegylated liposomal doxorubicin, rituximab, cyclophosphamide, doxorubicin, dexamethasone, prednisolone or thalidomide for patients who have not started treatment and are ineligible for blood stem cell transplant.

Uses of Mibor 2mg Injection:

Mibor 2mg Injection is indicated to treat the following conditions:

• Multiple myeloma.
• Mantle cell lymphoma.

How Mibor 2mg Injection works:

Mibor 2mg Injection works by exerting a toxic effect on cancer cells. It inhibits the 26S proteasome and blocks a major cell signaling pathway. This inhibition of signaling pathway makes the cancer cells sensitive to chemotherapy. This medicine also enhances the build up of a protein, ‘Bax’, that affects the cell cycle, ultimately minimizing the cancer cell growth and multiplication.

Interaction with other drugs:

Inform your doctor about any medications you are taking or have taken before the treatment.

More Information:

Store unopened vials in the refrigerator and protect them from light. This injection is for single use only. Discard any unused portion or waste products.

References:

1. STADA, Electronic Medicines Compendium (EMC), [Revised on Jun 2021] [Accessed on 29th Dec 2021], https://www.medicines.org.uk/emc/files/pil.10201.pdf 
2. Takeda Pharmaceuticals U.S.A., Inc., [Revised on Nov 2021] [Accessed on 29th Dec 2021], https://www.velcade.com/files/pdfs/VELCADE_PRESCRIBING_INFORMATION.pdf 
3. Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.
4. KD Tripathi, Anticancer Drugs, Essentials of Medical Pharmacology, 8th Edition, 2019, 915-936.
5. H.G. Watson, J.I.O. Craig, L.M. Manson, Blood disease, Davidson’s Principles and Practice of Medicine, 22nd Edition, 2014, 989-1056.

How to use Mibor 2mg Injection:

This injection should be administered by a qualified healthcare professional experienced in the use of cytotoxic medications.

Safety Advice:

Pregnancy:

Inform your physician before taking if you are pregnant or think you might be pregnant. Your physician will determine the suitability and safe use of this medicine.

Breastfeeding: 

Breastfeeding during this treatment may not be safe. Your physician might suggest you to stop breastfeeding for some time, depending on your condition. Discuss with your physician when it is safe to restart breastfeeding after this treatment.   

Liver:

Inform your physician before starting this treatment if you have Hepatitis infection or liver disease. Your physician will monitor your liver functions regularly.

Kidney:

Inform your physician before starting this treatment if you have kidney diseases. Your physician will monitor your kidney functions regularly.

Driving: 

Avoid driving or using machinery if you experience side effects like fainting, dizziness or blurred vision.

Others:

• This injection is not recommended if you have severe lung or heart problems. Inform your physician before starting this treatment if you have issues in your lungs or heart.
• Inform your physician if you experience allergic reactions to this injection, boron or mannitol.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Serious:

• Muscle cramps
• Confusion, visual disturbances, seizures and headache
• Breathlessness
• Swelling of feet
• Changes in heartbeat
• High BP
• Fainting and tiredness
• Cough and chest tightness

Common:

• Pneumonia
• Loss of appetite
• Sensitivity, tingling and burning sensation of the skin
• Nausea, vomiting and diarrhea
• Mouth ulcers
• Constipation
• Muscle and bone pain
• Hair loss
• Fever
• Reduction in blood cell count
• Reduced kidney function
• Shivering
• Infections
• Itching and redness
• Dehydration
• Stomach problems
• Difficulty sleeping, anxiety, mood swings, depressed mood

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