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Myostigmin 0.5mg Injection

Prescription Required

Salt Composition : Neostigmine Methyl Sulphate


Origin of Medicine : India

MRP: 4.83
Price :4
You Save :1 (17%)

1 Ampoule(s) Of 1ml

Introduction to Myostigmin 0.5mg Injection

Myostigmin 0.5 mg contains an active component such as Neostigmine methyl sulphate. It is a medication primarily used to treat myasthenia gravis, a neuromuscular disorder that leads to muscle weakness and fatigue. It can be used to treat postoperative paralytic ileus, a condition where the normal contractions of the intestines are reduced or absent after surgery. It helps enhance gastrointestinal motility. This medication can reverse the effects of certain muscle relaxants used during surgical procedures. In some cases, it may be used to manage orthostatic hypotension, a condition where blood pressure drops significantly upon standing up. It might be used to manage certain types of dysautonomia and autonomic nervous system disorders that can lead to various symptoms, including dizziness, heart rate irregularities, and difficulty regulating body temperature.

You should not use it if you have a known allergy or hypersensitivity to Myostigmin 0.5 mg or any ingredients in the medication. It can affect heart rate and cardiac conduction, so it should be avoided for individuals with bradycardia (slow heart rate) or heart block. It may worsen symptoms in individuals with uncontrolled hyperthyroidism. It should not be used as a treatment for hyperthyroidism. It can exacerbate respiratory symptoms and is not used to treat acute asthma attacks. It can be used in children with myasthenia gravis or other neuromuscular conditions, but the dosage and administration might differ from adults. Myostigmin 0.5 mg can be used in the elderly, but dosage adjustments might be necessary due to potential age-related changes in metabolism and other health considerations.

Uses of Myostigmin 0.5mg Injection

Myostigmin 0.5 mg injection is used in the following:

  • Myasthenia gravis management
  • Reversal of neuromuscular blockade
  • Postoperative paralytic ileus treatment
  • Orthostatic hypotension management
  • Dysautonomia symptom relief
  • Reversal of neuromuscular effects

Therapeutic Effects of Myostigmin 0.5mg Injection

Myostigmin 0.5 mg injection works by inhibiting the action of acetylcholinesterase, an enzyme that breaks down the neurotransmitter acetylcholine. By inhibiting this enzyme, Myostigmin 0.5 mg increases the levels of acetylcholine in the neuromuscular junction, which improves muscle function.

Interaction of Myostigmin 0.5mg Injection with other drugs

Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Myostigmin 0.5 mg, reducing effectiveness by causing undesirable side effects. 

More Information about Myostigmin 0.5mg Injection

  • Store at room temperature, between up to 20°C to 25°C
  • Keep away from moisture, heat, and light.
  • It should not be frozen.
  • Keep away from children and pets.

How to consume Myostigmin 0.5mg Injection

A healthcare provider can administer Myostigmin 0.5 mg as an intravenous injection. The healthcare provider determines the exact dose, duration, and frequency.

Safety Advices for Myostigmin 0.5mg Injection

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The safety of Myostigmin 0.5 mg during pregnancy should be discussed with your healthcare provider. They will consider the potential risks and benefits before making a recommendation.

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Breast Feeding


Myostigmin 0.5 mg might pass into breast milk, potentially affecting the nursing infant. Consult your healthcare provider before starting this medication.

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Myostigmin 0.5 mg injection can worsen respiratory symptoms, so individuals with lung conditions like asthma should consult a healthcare provider before using this medication.

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Myostigmin 0.5 mg injection might not be suitable for individuals with certain types of liver disease. It's important to discuss your specific liver condition with your healthcare provider before using it.

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It is not safe to use alcohol while taking Myostigmin 0.5 mg injection , as alcohol might enhance certain side effects and interactions.

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Myostigmin 0.5 mg injection can cause side effects like dizziness or blurred vision, which could impair your ability to drive safely. Consult your healthcare provider for guidance.

Side Effects of Myostigmin 0.5mg Injection

Myostigmin 0.5 mg can cause some side effects like all medications, although not everyone will experience them. 


  • Severe allergic reactions (rash, itching, swelling, severe dizziness, difficulty breathing)
  • Slow heart rate (bradycardia)
  • Heart rhythm abnormalities
  • Muscle weakness or twitching (beyond normal myasthenic symptoms)
  • Difficulty breathing or swallowing
  • Increased or uncontrolled muscle movements
  • Signs of cholinergic crisis (overdose)


  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal cramps
  • Increased salivation
  • Sweating
  • Muscle twitching or cramps
  • Blurred vision
  • Increased urination
  • Difficulty focusing

Word of Advice

Inform your healthcare provider about allergies, medical history (including heart, lung, gastrointestinal, and neurological conditions), and any medications you're taking before using Myostigmin 0.5 mg injection. Dosage adjustments might be needed for liver or kidney impairments. Regular monitoring for side effects, signs of overdose (cholinergic crisis), and response to treatment is crucial. If you have respiratory conditions, cardiovascular issues, or neurological disorders, discuss their impact on its use. Avoid abrupt discontinuation, self-administration of injections, and sudden changes to treatment. Store this medication properly, and consult your healthcare provider for any concerns or adjustments to your treatment plan.


Q 1. Is using Myostigmin 0.5 mg injection safe for a long period?

Long-term use of Myostigmin 0.5 mg injection is common for conditions like myasthenia gravis. Your healthcare provider will monitor you for any adverse effects of prolonged usage.

Q 2. How long does it take for Myostigmin 0.5 mg injection to start working?

The onset of action can vary, but some individuals might experience improvements within a few hours to days after starting Myostigmin 0.5 mg injection.

Q 3. Can I stop taking Myostigmin 0.5 mg abruptly?

Abruptly stopping Myostigmin 0.5 mg injection can lead to a worsening of symptoms. Consult your healthcare provider before making any changes to your treatment plan.

Q 4. Can Myostigmin 0.5 mg affect my exercise or physical activity ability?

Depending on your response to Myostigmin 0.5 mg injection, it might impact your physical abilities. Discuss any changes or concerns with your healthcare provider.

Q 5. Are there specific dietary restrictions while taking Myostigmin 0.5 mg injection?

There are generally no specific dietary restrictions, but if you have concerns about certain foods affecting your condition or medication, discuss them with your healthcare provider.

Q 6. Are the side effects of Myostigmin 0.5 mg injection temporary?

Some side effects, like nausea or vomiting, might temporarily improve over time as your body adjusts to the medication.

Fact Box of Myostigmin 0.5mg Injection

Molecule name:  Neostigmine methyl sulphate

Therapeutic class: Anticholinesterases

Pharmacological class:  Cholinesterase Inhibitor


1. Myasthenia gravis management

2. Reversal of neuromuscular blockade

3. Postoperative paralytic ileus treatment

4. Orthostatic hypotension management

5. Dysautonomia symptom relief

6. Reversal of neuromuscular effects


  1. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Anticholinesterase agents, 12th edition, 2011, 250.
  2. KD Tripathi, Essentials of Medical Pharmacology, Cholinergic system and drugs, 7th edition, 2013, 105-111.
  3. Hameln Pharma Ltd, Electronic medicines compendium (EMC), [Revised on Dec 2020] [ Accessed on 30th August 2023],
  4. Fresenius kabi USA LLC, US Food and Drug Administration, [Revised on Jan 2015] [ Accessed on 30th August 2023],


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