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Nab Pacliage Injection
Prescription Required
Salt Composition : Paclitaxel,human Albumin
Manufacturer : AEGIS PHARMACEUTICALS
Origin of Medicine : India
1 Vial(s)
Introduction to Nab Pacliage Injection
Nab Pacliage Injection is a specialized formulation combining the anti-cancer drug paclitaxel with human albumin, a protein naturally found in the body. This novel combination belongs to the therapeutic class of antineoplastic agents and is primarily used to treat various cancers, including metastatic breast cancer, non-small cell lung cancer (NSCLC), and advanced pancreatic cancer. By leveraging human albumin, the drug ensures better solubility and delivery of paclitaxel, enhancing its therapeutic effects while reducing solvent-related side effects.
Nab Pacliage Injection is administered via intravenous infusion and should be used under the supervision of a qualified healthcare professional. Safety precautions are essential, as the drug is contraindicated in patients with hypersensitivity to its components and those with severe liver impairment. Pregnant and breastfeeding women are advised to avoid using this medication due to its potential risks.
Warnings associated with Nab Pacliage Injection include myelosuppression (reduced bone marrow activity), risk of infections, and potential nerve damage. Careful monitoring and adherence to dosing schedules are crucial to achieving the best possible outcomes.
Uses of Nab Pacliage Injection
Nab Pacliage Injection is FDA-approved for the treatment of:
- Metastatic breast cancer
- Non-small cell lung cancer (NSCLC)
- Advanced pancreatic cancer
Therapeutic Effects of Nab Pacliage Injection
Paclitaxel, the active ingredient in this formulation, works by disrupting the division and growth of cancer cells. It targets the microtubules within the cells, which are essential for cell division. By stabilizing these structures, the drug prevents cancer cells from completing their lifecycle, leading to cell death. The inclusion of human albumin enhances drug delivery to tumors, making the treatment more effective and reducing side effects commonly associated with traditional solvents.
Interaction of Nab Pacliage Injection with other drugs
Nab Pacliage Injection may interact with certain medications, potentially increasing the risk of side effects or reducing its efficacy. Notable interactions include:
- CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): May increase the concentration of paclitaxel in the blood, heightening side effects.
- CYP3A4 inducers (e.g., rifampin, phenytoin): Can lower paclitaxel levels, reducing its effectiveness.
- Anticoagulants (e.g., warfarin): Increases the risk of bleeding; monitor clotting parameters closely.
- Immunosuppressants (e.g., cyclosporine): May exacerbate immunosuppression, raising the risk of infections.
Patients must inform their healthcare provider about all medications and supplements they are using to avoid serious interactions.
More Information about Nab Pacliage Injection
- Store at 20–25°C in a cool, dry place away from direct sunlight.
- Contact your healthcare provider immediately if you miss a dose; do not self-adjust the schedule.
- Seek emergency medical attention if an overdose is suspected.
- Keep Nab Pacliage Injection out of reach of children.
How to consume Nab Pacliage Injection
The dose depends on the type and stage of cancer. A healthcare professional will determine the appropriate schedule. Nab Pacliage Injection is administered as an intravenous infusion. It can be taken without regard to meals.
Safety Advices for Nab Pacliage Injection
Pregnancy
Nab Pacliage Injection can harm the unborn baby and should not be used during pregnancy unless absolutely necessary.
Breast Feeding
Breastfeeding is not recommended while taking Nab Pacliage Injection as the drug can pass into breast milk and harm the infant.
Lungs
Patients with pre-existing lung issues should discuss their condition before starting treatment, as it may exacerbate breathing difficulties.
Liver
Dose adjustments may be required for patients with liver impairment. Routine liver function tests are advised.
Alcohol
Alcohol consumption should be avoided as it may interact with the medication or worsen side effects.
Driving
Nab Pacliage Injection may cause dizziness, fatigue, or neuropathy, affecting the ability to drive safely.
Side Effects of Nab Pacliage Injection
Common Side Effects:
- Nausea and vomiting
- Fatigue
- Hair loss
- Muscle or joint pain
- Mild diarrhea
Serious Side Effects:
- Severe allergic reactions (rash, swelling, difficulty breathing)
- Peripheral neuropathy (numbness or tingling in hands/feet)
- Neutropenia (low white blood cell count)
- Severe liver enzyme elevation
Word of Advice
Patients undergoing treatment with Nab Pacliage Injection should follow their doctor’s instructions carefully and attend all scheduled appointments for monitoring. Ensure you inform your healthcare provider about any pre-existing conditions, current medications, or supplements. Stay hydrated and maintain a balanced diet to support overall health during treatment. If any side effects become severe, seek medical attention promptly.
FAQs
Q 1. What is Nab Pacliage Injection used for?
Nab Pacliage Injection treats metastatic breast cancer, non-small cell lung cancer, and advanced pancreatic cancer. It is particularly effective in cases where other treatments may not be tolerated.
Q 2. How does Nab Pacliage Injection work?
It disrupts cancer cell division by stabilizing microtubules, leading to cell death. The inclusion of human albumin improves drug delivery to the tumor.
Q 3. Are there any dietary restrictions while using Nab Pacliage Injection?
Avoid grapefruit and grapefruit juice as they can interfere with drug metabolism. Follow a balanced diet to manage treatment-related side effects.
Q 4. Can Nab Pacliage Injection affect fertility?
Yes, Nab Pacliage Injection may impact fertility in both men and women. Discuss fertility preservation options with your doctor before starting treatment.
Fact Box of Nab Pacliage Injection
Molecule name: Paclitaxel, Human albumin
| Pharmacological class: Antineoplastic agent |
| Therapeutic class: Chemotherapeutic agent | Indications: 1. Breast cancer 2. Non-small cell lung cancer 3. Pancreatic cancer |
References
- Stinchcombe TE. Nanoparticle albumin-bound paclitaxel: a novel Cremphor-EL-free formulation of paclitaxel. Nanomedicine (Lond). 2007 Aug;2(4):415-23. doi: 10.2217/17435889.2.4.415. PMID: 17716129. https://pubmed.ncbi.nlm.nih.gov/17716129/
- https://pubs.rsc.org/en/content/articlelanding/2014/md/c4md00200h
- https://www.cancer.gov/publications/dictionaries/cancer-terms/def/paclitaxel-albumin-stabilized-nanoparticle-formulation
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